Naegleria fowleri phát triển trong môi trường các vật dụng nước ngọt ấm (warm freshwater bodies) và đi vào cơ thể người thông qua đường mũi. Sau đó, nó đi vào trong não ăn các tế bào mạch máu và mô não, gây nên nhu mô não sưng phồng. Nó có thẻ giết chết người trong vòng 1 tuần. Trong số 143 ca được ghi nhận kể từ năm 1962, chỉ có 4 ca sống sót và nhiễm trùng thì rất hiếm.

Từ năm 2007-2016, có tất cả 40 ca tại Mỹ và phần lớn ở các bang chưa có ca bệnh ít nhất từ năm 1962. Số ca bệnh do Naegleria fowleri tại Mỹ từ năm 1962-2016 theo báo cáo của Trung tâm Center for Disease Control and Prevention như bản đồ dưới đây.

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Naegleria fowleri infections.

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Brain-Eating Amoebae: Silver Nanoparticle Conjugation Enhanced Efficacy of Anti-Amoebic Drugs against Naegleria fowleri.

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Brain-Eating Amoebae: Predilection Sites in the Brain and Disease Outcome.

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Primary Amebic Meningoencephalitis in Children: A Report of Two Fatal Cases and Review of the Literature.

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Naegleria fowleri after 50 years: is it a neglected pathogen?

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Successful treatment of Naegleria fowleri meningoencephalitis by using intravenous amphotericin B, fluconazole and rifampicin.

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Cytopathogenesis of Naegleria fowleri Thai strains for cultured human neuroblastoma cells.

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Photo Quiz: An 8-Year-Old Boy with Meningoencephalitis.

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Elimination of Naegleria fowleri from bulk water and biofilm in an operational drinking water distribution system.

Miller HC, Morgan MJ, Wylie JT, Kaksonen AH, Sutton D, Braun K, Puzon GJ.

Water Res. 2017 Mar 1;110:15-26. doi: 10.1016/j.watres.2016.11.061. Epub 2016 Nov 27.

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Characterization of a Drinking Water Distribution Pipeline Terminally Colonized by Naegleria fowleri.

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Notes from the Field: Primary Amebic Meningoencephalitis Associated with Exposure to Swimming Pool Water Supplied by an Overland Pipe - Inyo County, California, 2015.

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Toll-like receptors participate in Naegleria fowleri recognition.

Martínez-Castillo M, Santos-Argumedo L, Galván-Moroyoqui JM, Serrano-Luna J, Shibayama M.

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Fatal primary amoebic meningoencephalitis in a Norwegian tourist returning from Thailand.

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Comparison of biofilm ecology supporting growth of individual Naegleria species in a drinking water distribution system.

Puzon GJ, Wylie JT, Walsh T, Braun K, Morgan MJ.

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Scanning electron microscopic study of human neuroblastoma cells affected with Naegleria fowleri Thai strains.

Tiewcharoen S, Rabablert J, Chetanachan P, Junnu V, Worawirounwong D, Malainual N.

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Heat shock protein 70 of Naegleria fowleri is important factor for proliferation and in vitro cytotoxicity.

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Computational identification of putative miRNAs and their target genes in pathogenic amoeba Naegleria fowleri.

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Competition between Naegleria fowleri and Free Living Amoeba Colonizing Laboratory Scale and Operational Drinking Water Distribution Systems.

Miller HC, Wylie JT, Kaksonen AH, Sutton D, Puzon GJ.

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Nf-GH, a glycosidase secreted by Naegleria fowleri, causes mucin degradation: an in vitro and in vivo study.

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Quantitative assessment of Naegleria fowleri and fecal indicator bacteria in brackish water of Lake Pontchartrain, Louisiana.

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Expression, purification, enzymatic characterization and crystallization of glyceraldehyde-3-phosphate dehydrogenase from Naegleria gruberi, the first o­ne from phylum Percolozoa.

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Primary amoebic meningoencephalitis in an Iranian infant.

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Primary Amebic Meningoencephalitis: What Have We Learned in the Last 5 Years?

Cope JR, Ali IK.

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An In Vitro Model of the Blood-Brain Barrier: Naegleria fowleri Affects the Tight Junction Proteins and Activates the Microvascular Endothelial Cells.

Coronado-Velázquez D, Betanzos A, Serrano-Luna J, Shibayama M.

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Fatal case of amoebic encephalitis masquerading as herpes.

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Pharmacy Students' Knowledge Assessment of Naegleria fowleri Infection.

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Future Priorities in Tackling Infections Due to Brain-Eating Amoebae.

Khan NA, Anwar A, Siddiqui R.

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