Trong thời gian 5 năm trở lại đây, bệnh do lây truyền từ động vật sang người ngày càng trở nên phổ biến với tần suất gặp trên lâm sàng ngày càng tăng, một trong những căn bệnh đó là bệnh do ấu trùng giun đũa chó/ mèo Toxocara canis và Toxocara cati. Nhiều nghiên cứu trên thế giới và Việt Nam đã và đang tiếp tục triển khai trên cộng đồng và trong cơ ở bệnh viện. Nhân đây, chúng tôi xin chia sẻ một số công trình nghiên cứu về bệnh này trong thời gian qua.

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Seroepidemiological study and associated risk factors of Toxocara canis infection among preschool children in Osun State, Nigeria.

Sowemimo OA, Lee YL, Asaolu SO, Chuang TW, Akinwale OP, Badejoko BO, Gyang VP, Nwafor T, Henry E, Fan CK.

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Characterisation of Tc-cpl-1, a cathepsin L-like cysteine protease from Toxocara canis infective larvae.

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Evaluation of follow-up of therapy with fenbendazole incorporated into stabilized liposomes and immunomodulator glucan in mice infected with Toxocara canis larvae.

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Sero-detection of Toxocara canis infection in human with T.canis recombinant arginine kinase, cathepsin L-1 and TES-26 antigens.

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Toxocara canis larvae reinfecting BALB/c mice exhibit accelerated speed of migration to the host CNS.

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Comparison of the sensitive screening kit with two ELISA sets for detection of anti-Toxocara antibodies.

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Toxocara spp. seroprevalence in sheep from southern Brazil.

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The hamster (Mesocricetus auratus) as an experimental model of toxocariasis: histopathological, immunohistochemical, and immunoelectron microscopic findings.

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Epidemiology of human toxocariasis in Poland - A review of cases 1978-2009.

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Parasite-specific antibody profile in the aqueous humor of rabbits with ocular toxocariasis.

Akiyama T, Ohta N.

Parasitol Int. 2010 Jun;59(2):112-20. doi: 10.1016/j.parint.2009.11.002. Epub 2009 Dec 4.

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The significance of cerebral toxocariasis: a model system for exploring the link between brain involvement, behaviour and the immune response.

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Persistent airway hyper-responsiveness and inflammation in Toxocara canis-infected BALB/c mice.

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Ocular larva migrans caused by Toxocara cati in Mongolian gerbils and a comparison of ophthalmologic findings with those produced by T. canis.

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Toxocara spp. infections in paratenic hosts.

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rTES-30USM: cloning via assembly PCR, expression, and evaluation of usefulness in the detection of toxocariasis.

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Proteinases in excretory-secretory products of Toxocara canis second-stage larvae: zymography and modeling insights.

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Development of a highly sensitive IgG-ELISA based o­n recombinant arginine kinase of Toxocara canis for serodiagnosis of visceral larva migrans in the murine model.

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Method for detecting circulating Toxocara canis antigen and its application in human serum samples.

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Immunomodulative effect of muramyldipeptide in mice with larval toxocarosis.

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Inhibition of interleukin 5 production with no influence o­n interleukin 4 production by an anti-allergic drug, tranilast, in Toxocara canis-infected mice.

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The in vitro effect of prolactin o­n the growth, motility and expression of prolactin receptors in larvae of Toxocara canis.

Chávez-Güitrón LE, Morales-Montor J, Muñoz-Guzmán MA, Nava-Castro KE, Ramírez-Álvarez H, Moreno-Méndoza NA, Hernández-Cervantes R, Alba-Hurtado F.

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Persistence of specific antibody response in different experimental infections of mice with Toxocara canis larvae.

Chieffi PP, Peres BA, de Mello EO, Kanamura H, Brandão MM.

Rev Inst Med Trop Sao Paulo. 1995 May-Jun;37(3):187-90.

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Lactobacillus rhamnosus reduces parasite load o­n Toxocara canis experimental infection in mice, but has no effect o­n the parasite in vitro.

Walcher DL, Cruz LAX, de Lima Telmo P, Martins LHR, da Costa de Avila LF, Berne MEA, Scaini CJ.

Parasitol Res. 2018 Feb;117(2):597-602. doi: 10.1007/s00436-017-5712-7. Epub 2017 Dec 14.

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Prolactin as immune cell regulator in Toxocara canis somatic larvae chronic infection.

Del Rio-Araiza VH, Nava-Castro KE, Alba-Hurtado F, Quintanar-Stephano A, Aguilar-Díaz H, Muñoz-Guzmán MA, Ostoa-Saloma P, Ponce-Regalado MD, Morales-Montor J.

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Variations in innate resistance to experimental Toxocara canis infection in two strains of mice.

Abo-Shehada MN, Herbert IV.

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Modulation of the host's immune response by schistosome larvae.

Jenkins SJ, Hewitson JP, Jenkins GR, Mountford AP.

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Evaluation of the transcription of interleukin-12 in the intestinal mucosa of mice subjected to experimental toxocariasis and supplemented with Saccharomyces boulardii.

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Glycoimmunology: ignore at your peril!

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