Trong tiến trình tiến tới phòng chống & loại trừ sốt rét trên thế giới cũng như tại Việt Nam, trong đó không kể đến việc loại trừ loài ký sinh trùng có chu kỳ sinh học và phát triển đặc biệt là Plasmodium vivax, vì khó khăn trong diệt trừ thể ẩn hay thể ngủ trong gan. Hơn nữa, theo khuyến cáo của Tổ chức Y tế thế giới và Bộ Y tế Việt Nam là phải dùng liệu trình dài 14 ngày của thuốc primaquine phosphate để diệt giao bào chống lây lan và diệt thể ẩn chống tái phát xa, nhằm tiến tới loại trừ sốt rét tốt nhất.

Tuy nhiên, khi áp dụng liệu trình dài ngày như vậy, không những khó đạt được sự chấp thuận và tuân thủ dùng thuốc của bệnh nhân sốt rét mà còn có thể có nguy cơ gây tán huyết trên các bệnh nhân vốn dĩ có cơ địa thiếu men G6PD. Do vậy, trong thời gian đến nếu việc nghiên cứu thuốc Tafenoquine có kết quả tốt, có thể đưa vào điều trị như một thuốc thay thế cho primaquine phosphate.

Các nghiên cứu từ năm 1974 đến 2017 đã được cập nhật và công bố được chia sẻ dưới đây:

Glucose-6-phosphate dehydrogenase deficiency in internationally adopted children.

Spring R, Schlaack H, Rice M, Staat MA, Quinn CT.

Pediatr Blood Cancer. 2018 May;65(5):e26990. doi: 10.1002/pbc.26990. Epub 2018 Jan 25.

PMID: 29369491 Similar articles Select item 2017792203.

Glucose-6-phosphate dehydrogenase deficiency and lung cancer: a hospital based case-control study.

Pisano M, Cocco P, Cherchi R, o­nnis R, Cherchi P.

Tumori. 1991 Feb 28;77(1):12-5.

PMID: 2017792 Similar articles Select item 29375871204.

Fulminant hemolysis in glucose-6-phosphate dehydrogenase deficiency.

Moiz B, Ali SA.

Clin Case Rep. 2017 Nov 24;6(1):224-225. doi: 10.1002/ccr3.1290. eCollection 2018 Jan.

PMID: 29375871 Free PMC Article Similar articles Select item 25487752205.

Prominent basophilic stippling and hemochromatosis in glucose-6-phosphate dehydrogenase deficiency.

Vander Meeren S, Van Damme A, Jochmans K.

Int J Hematol. 2015 Feb;101(2):112-3. doi: 10.1007/s12185-014-1716-6. Epub 2014 Dec 9. No abstract available.

PMID: 25487752 Similar articles Select item 1861285206.

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Plasma iron and iron proteins in erythrocyte glucose-6-phosphate dehydrogenase deficient newborns.

Wong CT, Saha N.

J Trop Pediatr. 1991 Jun;37(3):140. doi: 10.1093/tropej/37.3.140. No abstract available.

PMID: 1861285 Similar articles Select item 28875002207.

Prevalence of G6PD deficiency in Children with Hepatitis A.

Miri-Aliabad G, Khajeh A, Shahraki T.

Int J Hematol o­ncol Stem Cell Res. 2017 Apr 1;11(2):92-95.

PMID: 28875002 Free PMC Article Similar articles Select item 5662656208.

59Fe study of red blood cells life span in glucose-6-phosphate dehydrogenase deficiency heterozygote.

Pawlak A.

Humangenetik. 1968;5(3):231-6. No abstract available.

PMID: 5662656 Similar articles Select item 18774203209.

[Ofloxacin is contraindicated in case of G6PD deficiency: is it evidenced based?].

Carmoi T, Bordier L, Bonnefoy S, Callot D, Lecoules S, Algayres JP.

Rev Med Interne. 2009 Apr;30(4):355-7. doi: 10.1016/j.revmed.2008.07.007. Epub 2008 Sep 5. French.

PMID: 18774203 Similar articles Select item 28950694210.

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Colorectal Cancer Mortality in Relation to Glucose-6-Phosphate Dehydrogenase Deficiency and Consanguinity in Sardinia: A Spatial Correlation Analysis

Pes GM, Bassotti G, Dore MP.

Asian Pac J Cancer Prev. 2017 Sep 27;18(9):2403-2407.

PMID: 28950694 Free PMC Article Similar articles Select item 12119928211.

Variations in salicylamide glucuronide formation in normal and in G-6-PD-deficient children.

Cassimos C, Malaka-Zafiriu K, Tsiures T, Danielides B.

J Pediatr. 1974 Jan;84(1):110-1. No abstract available.

PMID: 12119928 Similar articles Select item 459996212.

Can elevated levels of copper in drinking water precipitate aucte hemolysis in G-6-PD deficient individuals?

Calabrese EJ, Moore GS.

Med Hypotheses. 1979 Apr;5(4):493-8.

PMID: 459996 Similar articles Select item 11599367213.

[Influence of huanglian used in combination with huangqin and gancao o­n the erythrocytic osmotic fragilitas of experimental glucose-6-phosphate dehydrogenase deficiency in rats].

Lin N, Gao X, Li J, Zhu J.

Zhongguo Zhong Yao Za Zhi. 1998 Oct;23(10):630-2, inside back cover. Chinese.

PMID: 11599367 Similar articles Select item 13952958214.

Erythrocyte glucose-6-phosphate dehydrogenase and malaria in Thailand.

HARRIS R.

Lancet. 1962 Dec 29;2(7270):1378-9. No abstract available.

PMID: 13952958 Similar articles Select item 13927068215.

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Erythrocyte glucose-6-phosphate dehydrogenase and malaria in Thailand.

KRUATRACHUE M, CHAROENLARP P, CHONGSUPHAJAISIDDHI T, HARINASUTA C.

Lancet. 1962 Dec 8;2(7267):1183-6. No abstract available.

PMID: 13927068 Similar articles Select item 24014946216.

Interesting case of G6PD deficiency anemia with severe hemolysis.

Chhabra A, Raj D, Choudhary PN, Grover A.

Asian J Transfus Sci. 2013 Jul;7(2):147-8. doi: 10.4103/0973-6247.115574.

PMID: 24014946 Free PMC Article Similar articles Select item 28195434217.

A patient with both methemoglobinemia and G6PD deficiency: A therapeutic conundrum.

Reading NS, Ruiz-Bonilla JA, Christensen RD, Cáceres-Perkins W, Prchal JT.

Am J Hematol. 2017 May;92(5):474-477. doi: 10.1002/ajh.24683. Epub 2017 Mar 24. No abstract available.

PMID: 28195434 Free PMC Article Similar articles Select item 29850382218.

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New Diagnosis of G6PD Deficiency Presenting as Severe Rhabdomyolysis.

Eziokwu AS, Angelini D.

Cureus. 2018 Mar 28;10(3):e2387. doi: 10.7759/cureus.2387.

PMID: 29850382 Free PMC Article Similar articles Select item 28894556219.

How We Manage Invasive Fungal Disease in Acute Myeloid Leukemia Patients with Glucose 6 Dehydrogenase Deficiency.

Sanna M, Caocci G, La Nasa G.

Mediterr J Hematol Infect Dis. 2017 Aug 14;9(1):e2017047. doi: 10.4084/MJHID.2017.047. eCollection 2017.

PMID: 28894556 Free PMC Article Similar articles Select item 27038219220.

Iron overload, G6PD deficiency, and lead levels o­n blood smears.

Pigatto PD, Ronchi A, Guzzi G.

Int J Hematol. 2016 Jun;103(6):724. doi: 10.1007/s12185-016-1990-6. Epub 2016 Apr 1. No abstract available.

PMID: 27038219 Similar articles

Caring for Glucose-6-Phosphate Dehydrogenase (G6PD)-Deficient Patients: Implications for Pharmacy.

Bubp J, Jen M, Matuszewski K.

P T. 2015 Sep;40(9):572-4.

PMID: 26417175 Free PMC Article Similar articles Select item 6107484222.

Diminished response to cytotoxic therapy in G-6-PD deficiency.

Pani P, Dessi S, Altieri M, Mascia V, Ionta MT, Pellegrini A.

Lancet. 1980 Oct 11;2(8198):803-4. No abstract available.

PMID: 6107484 Similar articles Select item 27650490223.

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What G6PD-deficient individuals should really avoid.

Lee SW, Chaiyakunapruk N, Lai NM.

Br J Clin Pharmacol. 2017 Jan;83(1):211-212. doi: 10.1111/bcp.13091. Epub 2016 Sep 20. No abstract available.

PMID: 27650490 Free PMC Article Similar articles Select item 29317868224.

Effect of High-Dose Vitamin C Infusion in a Glucose-6-Phosphate Dehydrogenase-Deficient Patient.

Quinn J, Gerber B, Fouche R, Kenyon K, Blom Z, Muthukanagaraj P.

Case Rep Med. 2017;2017:5202606. doi: 10.1155/2017/5202606. Epub 2017 Nov 26.

PMID: 29317868 Free PMC ArticleSimilar articles Select item 28796652225.

Acyanotic Hypoxia in a Febrile Child.

Murphy F, Blackham J, Moppett J, Lyttle M.

Pediatr Emerg Care. 2018 May;34(5):e95-e96. doi: 10.1097/PEC.0000000000001257.

PMID: 28796652 Similar articles

"Glucose-6-phosphate dehydrogenase deficiency". Genetics Home Reference. 6 December 2017. Retrieved 10 December 2017.

"Glucose-6-Phosphate Dehydrogenase Deficiency". NORD (National Organization for Rare Disorders). 2017. Retrieved 11 December 2017.

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Luzzatto, L. "GLUCOSE-6-PHOSPHATE DEHYDROGENASE DEFICIENCY." Advanced Medicine-Twelve: Proceedings of a Conference Held at the Royal College of Physicians of London, 11–14 February 1985. Vol. 21. Churchill Livingstone, 1986.

"Triggers of G6PD crisis" (PDF). Sydney Local Health District.

Glucose-6-Phosphate Dehydogenase Deficiency (G6PD) o­n The Jewish Genetic Disease Consortium (JGDC) website [1].Archived 1 July 2017 at the Wayback Machine.

Frank JE (2005). "Diagnosis and management of G6PD deficiency". Am Fam Physician. 72 (7): 1277–82. PMID16225031.

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A comprehensive list of drugs and chemicals that are potentially harmful in G6PD deficiency can be found in Beutler E (1994). "G6PD deficiency". Blood. 84 (11): 3613–36. PMID7949118..

Raupp P, Hassan JA, Varughese M, Kristiansson B (2001). "Henna causes life threatening haemolysis in glucose-6-phosphate dehydrogenase deficiency". Arch. Dis. Child. 85 (5): 411–2. doi:10.1136/adc.85.5.411. PMC1718961. PMID11668106.

Rees, DC; Kelsey, H; Richards, JD (27 March 1993). "Acute haemolysis induced by high dose ascorbic acid in glucose-6-phosphate dehydrogenase deficiency". BMJ (Clinical research ed.). 306 (6881): 841–2. doi:10.1136/bmj.306.6881.841. PMC1677333. PMID8490379.

Mehta, JB; Singhal, SB; Mehta, BC (13 October 1990). "Ascorbic-acid-induced haemolysis in G-6-PD deficiency". Lancet. 336 (8720): 944. doi:10.1016/0140-6736(90)92317-b. PMID1976956.

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http://www.britannica.com/EBchecked/topic/202897/favism

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Gaskin RS, Estwick D, Peddi R (2001). "G6PD deficiency: its role in the high prevalence of hypertension and diabetes mellitus". Ethnicity & disease. 11 (4): 749–54. PMID11763298.

WHO Working Group (1989). "Glucose-6-phosphate dehydrogenase deficiency". Bulletin of the World Health Organization. 67 (6): 601–11. PMC2491315. PMID2633878.

Monga A, Makkar RP, Arora A, Mukhopadhyay S, Gupta AK (July 2003). "Case report: Acute hepatitis E infection with coexistent glucose-6-phosphate dehydrogenase deficiency". Can J Infect Dis. 14 (4): 230–1. PMC2094938. PMID18159462.

Hamilton JW, Jones FG, McMullin MF (2004). "Glucose-6-phosphate dehydrogenase Guadalajara – a case of chronic non-spherocytic haemolytic anaemia responding to splenectomy and the role of splenectomy in this disorder". Hematology. 9 (4): 307–9. doi:10.1080/10245330410001714211. PMID15621740.

thefreedictionary.com > glucose-6-phosphate dehydrogenase deficiency citing: Gale Encyclopedia of Medicine. Copyright 2008

Cappellini MD, Fiorelli G (2008). "Glucose-6-phosphate dehydrogenase deficiency". Lancet. 371 (9606): 64–74. doi:10.1016/S0140-6736(08)60073-2. PMID18177777.

GBD 2013 Mortality and Causes of Death, Collaborators (2014). "Global, regional, and national age-sex specific all-cause and cause-specific mortality for 240 causes of death, 1990-2013: a systematic analysis for the Global Burden of Disease Study 2013". Lancet. 385: 117–71. doi:10.1016/S0140-6736(14)61682-2. PMC4340604. PMID25530442.

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G-6-PD FAQ section

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Nelson, David L.; Cox, Michael M. (2013). Lehninger Principles of Biochemistry (6th ed.). Basingstoke, England: Macmillan Higher Education. p. 576. ISBN978-1-4641-0962-1.

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Baird K. Origins and implications of neglect of G6PD deficiency and primaquine toxicity in Plasmodium vivax malaria. Pathogens and Global Health. 2015;109(3):93-106. doi:10.1179/2047773215Y.0000000016.

Beutler E (2008). "Glucose-6-phosphate dehydrogenase deficiency: a historical perspective". Blood. 111 (1): 16–24. doi:10.1182/blood-2007-04-077412. PMID18156501.

Simoons, F.J. (1996). "8". Plants of Life, Plants of Death. University of Wisconsin Press. p. 216. ISBN0299159043.

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Hyperbilirubinemia in healthy neonates with glucose-6-phosphate dehydrogenase deficiency.

Weng YH, Chou YH, Lien RI.

Early Hum Dev. 2003 Apr;71(2):129-36.

PMID: 12663150 Similar articles Select item 637335287.

Plasmodium falciparum: thiol status and growth in normal and glucose-6-phosphate dehydrogenase deficient human erythrocytes.

Miller J, Golenser J, Spira DT, Kosower NS.

Exp Parasitol. 1984 Jun;57(3):239-47.

PMID: 6373352 Similar articles Select item 1532232988.

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The relationship between the enzyme activity, lipid peroxidation and red blood cells deformability in hemizygous and heterozygous glucose-6-phosphate dehydrogenase deficient individuals.

Gurbuz N, Yalcin O, Aksu TA, Baskurt OK.

Clin Hemorheol Microcirc. 2004;31(3):235-42.

PMID: 15322329 Similar articles Select item 880860589.

Somatic-cell selection is a major determinant of the blood-cell phenotype in heterozygotes for glucose-6-phosphate dehydrogenase mutations causing severe enzyme deficiency.

Filosa S, Giacometti N, Wangwei C, De Mattia D, Pagnini D, Alfinito F, Schettini F, Luzzatto L, Martini G.

Am J Hum Genet. 1996 Oct;59(4):887-95.

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Content of reduced glutathione and consequences in recipients of glucose-6-phosphate dehydrogenase deficient red blood cells.

Huang CS, Sung YC, Huang MJ, Yang CS, Shei WS, Tang TK.

Am J Hematol. 1998 Mar;57(3):187-92.

PMID: 9495367 Free Article Similar articles Select item 2446002591.

Glucose-6-Phosphate Dehydrogenase (G6PD) deficiency in Greek newborns: the Mediterranean C563T mutation screening.

Molou E, Schulpis KH, Thodi G, Georgiou V, Dotsikas Y, Papadopoulos K, Biti S, Loukas YL.

Scand J Clin Lab Invest. 2014 Apr;74(3):259-63. doi: 10.3109/00365513.2013.879733. Epub 2014 Jan 24.

PMID: 24460025 Similar articles Select item 2689429792.

Assessment of Point-of-Care Diagnostics for G6PD Deficiency in Malaria Endemic Rural Eastern Indonesia.

Satyagraha AW, Sadhewa A, Elvira R, Elyazar I, Feriandika D, Antonjaya U, Oyong D, Subekti D, Rozi IE, Domingo GJ, Harahap AR, Baird JK.

PLoS Negl Trop Dis. 2016 Feb 19;10(2):e0004457. doi: 10.1371/journal.pntd.0004457. eCollection 2016 Feb.

PMID: 26894297 Free PMC Article Similar articles Select item 114314593.

The detection of glucose-6-phosphate dehydrogenase deficiency in mediterraneans by comparative quantitative enzyme electrophoresis.

Smith MB, Whiteside MG.

Med J Aust. 1975 May 3;1(18):558-9.

PMID: 1143145 Similar articles Select item 1040757994.

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Evaluation of the blue formazan spot test for screening glucose 6 phosphate dehydrogenase deficiency.

Pujades A, Lewis M, Salvati AM, Miwa S, Fujii H, Zarza R, Alvarez R, Rull E, Corrons JL.

Int J Hematol. 1999 Jun;69(4):234-6.

PMID: 10407579 Similar articles Select item 881371695.

Hemolytic anemias due to erythrocyte enzyme deficiencies.

Jacobasch G, Rapoport SM.

Mol Aspects Med. 1996 Apr;17(2):143-70.

PMID: 8813716 Similar articles Select item 488964796.

Glucose-6-phosphate dehydrogenase deficient red cells: resistance to infection by malarial parasites.

Luzzatto L, Usanga FA, Reddy S.

Science. 1969 May 16;164(3881):839-42.

PMID: 4889647 Similar articles Select item 2622651597.

Prevalence and Molecular Characterization of Glucose-6-Phosphate Dehydrogenase Deficiency at the China-Myanmar Border.

Li Q, Yang F, Liu R, Luo L, Yang Y, Zhang L, Liu H, Zhang W, Fan Z, Yang Z, Cui L, He Y.

PLoS o­ne. 2015 Jul 30;10(7):e0134593. doi: 10.1371/journal.pone.0134593. eCollection 2015. Erratum in: PLoS o­ne. 2015;10(9):e0138038.

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Select item 2859179098.

Asian G6PD-Mahidol Reticulocytes Sustain Normal Plasmodium Vivax Development.

Bancone G, Malleret B, Suwanarusk R, Chowwiwat N, Chu CS, McGready R, Rénia L, Nosten F, Russell B.

J Infect Dis. 2017 Jul 15;216(2):263-266. doi: 10.1093/infdis/jix278.

PMID: 28591790 Free PMC Article Similar articles Select item 412506599.

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A technique for the cytochemical demonstration in the electron microscope of glucose-6-phosphate dehydrogenase activity in erythrocytes of malaria-infected animals.

Theakston RD, Fletcher KA.

J Microsc. 1973 Apr;97(3):315-20. No abstract available.

PMID: 4125065 Similar articles Select item 28356147100.

Genotypic and phenotypic characterization of G6PD deficiency in Bengali adults with severe and uncomplicated malaria.

Plewes K, Soontarawirat I, Ghose A, Bancone G, Kingston HWF, Herdman MT, Leopold SJ, Ishioka H, Faiz MA, Anstey NM, Day NPJ, Hossain MA, Imwong M, Dondorp AM, Woodrow CJ.

Malar J. 2017 Mar 29;16(1):134. doi: 10.1186/s12936-017-1788-x.

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Maintaining Specimen Integrity for G6PD Screening by Cytofluorometric Assays.

Kahn M, Ward WH, LaRue N, Kalnoky M, Pal S, Domingo GJ.

J Histochem Cytochem. 2015 Jun;63(6):454-8. doi: 10.1369/0022155415580594. Epub 2015 Mar 18. Erratum in: J Histochem Cytochem. 2016 Jun;64(6):394.

PMID: 25786434 Free PMC Article Similar articles Select item 7390473102.

Variants of erythrocyte glucose-6-phosphate dehydrogenase (G6PD) in Bulgarian populations.

Shatskaya TL, Krasnopolskaya KD, Tzoneva M, Mavrudieva M, Toncheva D.

Hum Genet. 1980;54(1):115-7.

PMID: 7390473 Similar articles Select item 2208076103.

Glucose-6-phosphate dehydrogenase (G6PD) activity in tumoral tissues of G6PD-deficient subjects affected by larynx carcinoma.

Dessì S, Batetta B, Pani P, Barra S, Miranda F, Puxeddu P.

Cancer Lett. 1990 Sep;53(2-3):159-62.

PMID: 2208076 Similar articles Select item 28099116104.

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Determination of glucose-6-phosphate dehydrogenase cut-off values in a Tunisian population.

Laouini N, Sahli CA, Jouini L, Haloui S, Fredj SH, Daboubi R, Siala H, Ouali F, Becher M, Toumi N, Bibi A, Messsaoud T.

Clin Chem Lab Med. 2017 Jul 26;55(8):1193-1201. doi: 10.1515/cclm-2016-0253.

PMID: 28099116 Similar articles Select item 20731290105.

Central retinal vein occlusion in an Army ranger with glucose-6-phosphate dehydrogenase deficiency.

Kotwal RS, Butler FK Jr, Murray CK, Hill GJ, Rayfield JC, Miles EA.

Mil Med. 2009 May;174(5):544-7.

PMID: 20731290 Similar articles Select item 28214533106.

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The effect and mechanism of inhibiting glucose-6-phosphate dehydrogenase activity o­n the proliferation of Plasmodium falciparum.

Zhang Z, Chen X, Jiang C, Fang Z, Feng Y, Jiang W.

Biochim Biophys Acta. 2017 May;1864(5):771-781. doi: 10.1016/j.bbamcr.2017.02.010. Epub 2017 Feb 15.

PMID: 28214533Free Article Similar articles Select item 28155142107.

Single Cell Cytochemistry Illustrated by the Demonstration of Glucose-6-Phosphate Dehydrogenase Deficiency in Erythrocytes.

Peters AL, van Noorden CJ.

Methods Mol Biol. 2017;1560:3-13. doi: 10.1007/978-1-4939-6788-9_1. Review.

PMID: 28155142Similar articles Select item 6331998108.

The relationship between glucose-6-phosphate dehydrogenase deficiency and cataracts in Sardinia. An epidemiological and biochemical study.

Orzalesi N, Fossarello M, Sorcinelli R, Schlich U.

Doc Ophthalmol. 1984 May 30;57(3):187-201.

PMID: 6331998 Similar articles Select item 26496826109.

Validation of the quantitative point-of-care CareStart biosensor for assessment of G6PD activity in venous blood.

Bancone G, Gornsawun G, Chu CS, Porn P, Pal S, Bansil P, Domingo GJ, Nosten F.

PLoS o­ne. 2018 May 8;13(5):e0196716. doi: 10.1371/journal.pone.0196716. eCollection 2018.

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Glucose 6 phosphate dehydrogenase deficiency unmasked by diabetic ketoacidosis: an underrated phenomenon.

Agarwal A, Nayak M D, Patil A, Manohar C.

J Clin Diagn Res. 2013 Dec;7(12):3012-3. doi: 10.7860/JCDR/2013/6159.3892. Epub 2013 Dec 15.

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Ultrasound-Guided Regional Anesthesia in a Glucose-6-Phosphate Dehydrogenase (G6PD)-Deficient Geriatric Trauma Patient.

Födinger AM, Kammerlander C, Luger TJ.

Geriatr Orthop Surg Rehabil. 2012 Dec;3(4):147-9. doi: 10.1177/2151458512472903.

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Diagnostic performances of the fluorescent spot test for G6PD deficiency in newborns along the Thailand-Myanmar border: A cohort study.

Thielemans L, Gornsawun G, Hanboonkunupakarn B, Paw MK, Porn P, Moo PK, Van Overmeire B, Proux S, Nosten F, McGready R, Carrara VI, Bancone G.

Wellcome Open Res. 2018 Jan 2;3:1. doi: 10.12688/wellcomeopenres.13373.1. eCollection 2018.

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Methemoglobinemia in an elderly patient with glucose-6-phosphate dehydrogenase deficiency: a case report.

Hassan KS, Al-Riyami AZ, Al-Huneini M, Al-Farsi K, Al-Khabori M.

Oman Med J. 2014 Mar;29(2):135-7. doi: 10.5001/omj.2014.33.

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