Blocking malaria transmission is an important step in eradicating malaria. In the field, transmission requires the production of sexual stagePlasmodiumparasites, called gametocytes, which are not effectively ki... Wei Sun, Xiuli Huang, Hao Li, Gregory Tawa, Ethan Fisher, Takeshi Q. Tanaka, Paul Shinn, Wenwei Huang, Kim C. Williamson and Wei Zheng Malaria Journal201716:147 In individuals living in malaria-endemic regions, parasitaemia thresholds for the onset of clinical symptoms vary with transmission intensity. The mechanisms that mediate this relationship are however, unclear... Temitope W. Ademolue, Yaw Aniweh, Kwadwo A. Kusi and Gordon A. Awandare Malaria Journal201716:145 Early diagnosis and prompt malaria treatment is essential to reduce progression of the illness to severe disease and, therefore, decrease mortality particularly among children under 5 years of age. This study ... Israel Mitiku and Adane Assefa Malaria Journal201716:144 The delivery of safe and effective radical cure forPlasmodium vivaxis one of the greatest challenges for achieving malaria elimination from the Asia?Pacific by 2030. During the annual meeting of the Asia Pacifi... Kamala Thriemer, Benedikt Ley, Albino Bobogare, Lek Dysoley, Mohammad Shafiul Alam, Ayodhia P. Pasaribu, Jetsumon Sattabongkot, Elodie Jambert, Gonzalo J. Domingo, Robert Commons, Sarah Auburn, Jutta Marfurt, Angela Devine, Mohammad M. Aktaruzzaman, Nayeem Sohel, Rinzin Namgay? Malaria Journal201716:141 A malaria hotspot in the southeastern region of Mauritania, near the Malian border, may hamper malaria control strategies. The objectives were to estimate the prevalence of genetic polymorphisms associated wit... Mohamed Salem Ould Ahmedou Salem, Khadijetou Mint Lekweiry, Houssem Bouchiba, Aurelie Pascual, Bruno Pradines, Ali Ould Mohamed Salem Boukhary, Sébastien Briolant, Leonardo K. Basco and Hervé Bogreau Malaria Journal201716:140 Transmission-blocking interventions (TBIs) aim to eliminate malaria by reducing transmission of the parasite between the host and the invertebrate vector. TBIs include transmission-blocking drugs and vaccines ... Ellie Sherrard-Smith, Thomas S. Churcher, Leanna M. Upton, Katarzyna A. Sala, Sara E. Zakutansky, Hannah C. Slater, Andrew M. Blagborough and Michael Betancourt Malaria Journal201716:137 Control of malaria increasingly involves administration of 8-aminoquinolines, with accompanying risk of haemolysis in individuals with glucose-6-phosphate dehydrogenase (G6PD) deficiency. Few data on the preva... Katherine Plewes, Ingfar Soontarawirat, Aniruddha Ghose, Germana Bancone, Hugh W. F. Kingston, M. Trent Herdman, Stije J. Leopold, Haruhiko Ishioka, Md. Abul Faiz, Nicholas M. Anstey, Nicholas P. J. Day, Md. Amir Hossain, Mallika Imwong, Arjen M. Dondorp and Charles J. Woodrow Malaria Journal201716:134 Although a number ofPlasmodium vivaxproteins have been identified, few have been investigated as potential vaccine candidates. This study characterized thePlasmodium vivaxmerozoite surface antigen 180 (PvMSA1... Fauzi Muh, Jin-Hee Han, Myat Htut Nyunt, Seong-Kyun Lee, Hye-Yoon Jeon, Kwon-Soo Ha, Won Sun Park, Seok-Ho Hong, Md Atique Ahmed, Sunghun Na, Eizo Takashima, Takafumi Tsuboi and Eun-Taek Han Malaria Journal201716:133 To date, human peripheral blood mononuclear cells (PBMCs) have been used mainly in immune stimulation assays and the interpretation of data can be influenced by the previous immunological history of donors and... Setthakit Chitsanoor, Sangdao Somsri, Panyu Panburana, Mathirut Mungthin, Ratawan Ubalee, Maliwan Emyeam, Somchai Jongwutiwes, Jetsumon Sattabongkot and Rachanee Udomsangpetch Malaria Journal201716:131 Malaria in pregnancy is common in sub-Saharan Africa where it contributes to perinatal morbidity and mortality. Use of insecticide-treated bed nets and intermittent preventive therapy with sulfadoxine?pyrimeth... Jodie Dionne-Odom, Andrew O. Westfall, Tobias O. Apinjoh, Judith Anchang-Kimbi, Eric A. Achidi and Alan T. N. Tita Malaria Journal201716:132 Rapid diagnostic tests (RDTs) are today the most widely used method for malaria diagnosis and are recommended, alongside microscopy, for the confirmation of suspected cases before the administration of anti-ma... Alfons Jimenez, Roxanne R. Rees-Channer, Rushini Perera, Dionicia Gamboa, Peter L. Chiodini, Iveth J. González, Alfredo Mayor and Xavier C. Ding Malaria Journal201716:128 Sri Lanka has achieved ?malaria-free? status and is now in the phase of prevention of re-introduction of malaria. Imported malaria remains a challenge to resurgence of the disease. The diagnostic challenges en... A. Dewanee Ranaweera, Manjula N. Danansuriya, Kusumawathie Pahalagedera, W. M. Kumudunayana T. de A. W. Gunasekera, Priyani Dharmawardena, Keng Wai Mak, Pei-Sze Jeslyn Wong, Mei-Zhi Irene Li, Cheong Huat Tan, Hapuarachchige C. Hapuarachchi, Hema D. B. Herath and Deepika Fernando Malaria Journal201716:126 Heads of Government from Asia and the Pacific have committed to a malaria-free region by 2030. In 2015, the total number of confirmed cases reported to the World Health Organization by 22 Asia Pacific countrie... Chris Erwin G. Mercado, Nattwut Ekapirat, Arjen M. Dondorp and Richard J. Maude Malaria Journal201716:127 Plasmodium falciparumgenetic polymorphisms that mediate altered drug sensitivity may impact upon virulence. In a cross-sectional study, Ugandan children with infections mutant atpfcr... Stephen Tukwasibwe, Patrick Tumwebaze, Melissa Conrad, Emmanuel Arinaitwe, Moses R. Kamya, Grant Dorsey, Samuel L. Nsobya, Bryan Greenhouse and Philip J. Rosenthal Malaria Journal201716:125 Risks of malaria epidemics in relation to El Niño and Southern Oscillation (ENSO) events have been mapped and studied at global level. In India, where malaria is a major public health problem, no such effort h... Ramesh C. Dhiman and Soma Sarkar Malaria Journal201716:122 Rapid diagnostic tests (RDTs) for histidine rich protein 2 (HRP2) are often used to determine whether persons with fever should be treated with anti-malarials. However,Plasmodium falciparumparasites with a dele... Christina T. Kozycki, Noella Umulisa, Stephen Rulisa, Emil I. Mwikarago, Jean Pierre Musabyimana, Jean Pierre Habimana, Corine Karema and Donald J. Krogstad Malaria Journal201716:123 Falciparum malaria is an important risk factor for African Burkitt lymphoma (BL), but few studies have evaluated malaria patterns in healthy BL-age children in populations where both diseases are endemic. To o... Marlena Maziarz, Tobias Kinyera, Isaac Otim, Paul Kagwa, Hadijah Nabalende, Ismail D. Legason, Martin D. Ogwang, Samuel Kirimunda, Benjamin Emmanuel, Steven J. Reynolds, Patrick Kerchan, Moses M. Joloba, Andrew W. Bergen, Kishor Bhatia, Ambrose O. Talisuna, Robert J. Biggar? Malaria Journal201716:124 Plasmodium falciparumdramatically alters the morphology and properties of the infected red blood cells (iRBCs). A large group of exported proteins participate in these parasite-host i... Xiaotong Zhu, Yang He, Yifan Liang, Osamu Kaneko, Liwang Cui and Yaming Cao Malaria Journal201716:121 Tânia do Socorro Souza Chaves, Wuelton Marcelo Monteiro, Jessé Reis Alves, Marcus Lacerda and Marta Heloisa Lopes Malaria Journal201716:120 One of the major challenges for control and elimination of malaria is ongoing spread and emergence of drug resistance. While epidemiology and surveillance of the drug resistance in falciparum malaria is being ... Myat Htut Nyunt, Jin-Hee Han, Bo Wang, Khin Myo Aye, Kyin Hla Aye, Seong-Kyun Lee, Ye Htut, Myat Phone Kyaw, Kay Thwe Han and Eun-Taek Han Malaria Journal201716:117 In response to increasing resistance to anti-malarial drugs, Senegal adopted artemisinin-based combination therapy (ACT) as the first-line treatment for uncomplicated malaria in 2006. However, resistance ofPlasm... Silman Diawara, Marylin Madamet, Mame Bou Kounta, Gora Lo, Khalifa Ababacar Wade, Aminata Nakoulima, Raymond Bercion, Rémy Amalvict, Mamadou Wague Gueye, Bécaye Fall, Bakary Diatta and Bruno Pradines Malaria Journal201716:118 Accurate diagnosis ofPlasmodiuminfection is crucial for prompt malaria treatment and surveillance. Microscopic examination has been widely applied as the gold standard for malaria diagnosis in most part of mala... Jung-Mi Kang, Pyo-Yun Cho, Mya Moe, Jinyoung Lee, Hojong Jun, Hyeong-Woo Lee, Seong Kyu Ahn, Tae Im Kim, Jhang Ho Pak, Moe Kyaw Myint, Khin Lin, Tong-Soo Kim and Byoung-Kuk Na Malaria Journal201716:119 To assess the effect on malaria prevalence, village specific monthly administrations of pyrimethamine, chlorproguanil, chloroquine or placebo were given to children in four previously treatment-naïve Liberian ... Irina T. Jovel, Anders Björkman, Cally Roper, Andreas Mårtensson and Johan Ursing Malaria Journal201716:113 Toll-interacting protein is a negative regulator in the TLR signaling cascade, particularly by impeding the TLR2 and, TLR4 pathway. Recently, TOLLIP was shown to regulate human TLR signaling pathways. Two common Larissa W. Brasil, Laila R. A. Barbosa, Felipe J. de Araujo, Allyson G. da Costa, Luan D. O. da Silva, Suzana K. Pinheiro, Anne C. G. de Almeida, Andrea Kuhn, Sheila Vitor-Silva, Gisely C. de Melo, Wuelton M. Monteiro, Marcus V. G. de Lacerda and Rajendranath Ramasawmy Malaria Journal201716:116 Non-human primates, such as the rhesus macaques, are the preferred model for down-selecting human malaria vaccine formulations, but the rhesus model is expensive and does not allow for direct efficacy testing ... Timothy W. Phares, Anthony D. May, Christopher J. Genito, Nathan A. Hoyt, Farhat A. Khan, Michael D. Porter, Margot DeBot, Norman C. Waters, Philippe Saudan and Sheetij Dutta Malaria Journal201716:115 Malaria is spread by mosquitoes that are increasingly recognised to have diverse biting behaviours. How a mosquito in a specific environment responds to differing availability of blood-host species is largely ... Laith Yakob, Mary Cameron and Jo Lines Malaria Journal201716:114 Despite increased efforts to control and ultimately eradicate human malaria,Plasmodium ovalemalaria is for the most part outside the focus of research or public health programmes. Importantly, the understanding... Mirjam Groger, Hannah S. Fischer, Luzia Veletzky, Albert Lalremruata and Michael Ramharter Malaria Journal201716:112 The Indian city of Chennai is endemic for malaria and the known local malaria vector isAnopheles stephensi.Plasmodium vivaxis the predominant malaria parasite species, thoughPlasmodium falciparumis present a... Shalu Thomas, Sangamithra Ravishankaran, N. A. Johnson Amala Justin, Aswin Asokan, Manu Thomas Mathai, Neena Valecha, Jacqui Montgomery, Matthew B. Thomas and Alex Eapen Malaria Journal201716:111 The burden of malaria in mobile populations remains poorly documented in sub-Saharan Africa. This study determined the prevalence of malaria among hawkers and long-distance truck drivers in the Greater Accra r... Nouhoum Diallo, Patricia Akweongo, Ernest Maya, Moses Aikins and Bismark Sarfo Malaria Journal201716:109 Malaria is the leading cause of death among children in Mozambique. Prevalence and factors associated with malaria are not well studied among children in rural Zambézia Province. Whether prevalence of malaria ... James G. Carlucci, Meridith Blevins Peratikos, Charlotte B. Cherry, Melanie L. Lopez, Ann F. Green, Lazaro González-Calvo and Troy D. Moon Malaria Journal201716:108 Primaquine is an anti-malarial used to preventPlasmodium vivaxrelapses and malaria transmission. However, PQ metabolites cause haemolysis in patients deficient in the enzyme glucose-6-phosphate dehydrogenase (G... Anna Caroline C. Aguiar, Flávio Jr. B. Figueiredo, Patrícia D. Neuenfeldt, Tony H. Katsuragawa, Bruna B. Drawanz, Wilson Cunico, Photini Sinnis, Fidel Zavala and Antoniana U. Krettli Malaria Journal201716:110 Botswana is one of the four front line malaria elimination countries in Southern Africa, with malaria control activities that include routine vector control. Past and recent studies have shown thatAnopheles arab... Leabaneng Tawe, Pleasure Ramatlho, Kelebogile Waniwa, Charles W. Muthoga, Ntebaleng Makate, Davis S. Ntebela, Isaac K. Quaye, Marco Pombi and Giacomo Maria Paganotti Malaria Journal201716:106 Considerable success in reducing malaria incidence and mortality has been achieved in Brazil, leading to discussions over the possibility of moving towards elimination. However, more than reporting and countin... Pedro M. Folegatti, André M. Siqueira, Wuelton M. Monteiro, Marcus Vinícius G. Lacerda, Chris J. Drakeley and Érika M. Braga Malaria Journal201716:107 Relatively large number of false-negative malaria rapid diagnostic test (RDT) results for microscopically confirmedPlasmodium falciparumcases were reported from five of the six administrative regions of Eritrea... Araia Berhane, Mulugeta Russom, Iyassu Bahta, Filmon Hagos, Michael Ghirmai and Selam Uqubay Malaria Journal201716:105 Cambodia reduced malaria incidence by more than 75% between 2000 and 2015, a target of the Millennium Development Goal 6. The Cambodian Government aims to eliminate all forms of malaria by 2025. The country?s ... Somony Heng, Lies Durnez, Sokny Mao, Sovannaroth Siv, Sochantha Tho, Vanna Mean, Vincent Sluydts and Marc Coosemans Malaria Journal201716:104 Imported malaria cases continue to be reported in Sri Lanka, which was declared ?malaria-free? by the World Health Organization in September 2016. Chemoprophylaxis, a recommended strategy for malaria preventio... A. Rajitha Wickremasinghe, Renu Wickremasinghe, Hemantha D. B. Herath and S. Deepika Fernando Malaria Journal201716:102 Anti-malarial herbal preparations (HPs) continue to enjoy high patronage in Ghana despite reports that the artemisinin-based combination therapy (ACT), the recommended first choice for treatment of uncomplicat... Dennis Wilmot, Elvis Ofori Ameyaw, Daniel Amoako-Sakyi, Johnson Nyarko Boampong and Neils Ben Quashie Malaria Journal201716:103 Malaria is endemic in most parts of Afghanistan and insecticide-based vector control measures are central in controlling the disease. Insecticide resistance in the main malaria vectorAnopheles stephensifrom Afg... Noor Halim Zahid Safi, Abdul Ali Ahmadi, Sami Nahzat, Seyyed Payman Ziapour, Seyed Hassan Nikookar, Mahmoud Fazeli-Dinan, Ahmadali Enayati and Janet Hemingway Malaria Journal201716:100 Avian malaria parasites (Plasmodiumspp.) and related haemosporidians (Haemosporida) are responsible for diseases which can be severe and even lethal in avian hosts. These parasites cause not only blood pathology... Gediminas Valki?nas and Tatjana A. Iezhova Malaria Journal201716:101 The widespread presence of low-density asymptomatic infections with concurrent gametocytes may be a stumbling block for malaria elimination. This study investigated the asymptomatic reservoir ofPlasmodium falcip... Fitsum G. Tadesse, Lotus van den Hoogen, Kjerstin Lanke, Jodie Schildkraut, Kevin Tetteh, Abraham Aseffa, Hassen Mamo, Robert Sauerwein, Ingrid Felger, Chris Drakeley, Endalamaw Gadissa and Teun Bousema Malaria Journal201716:99 Plasmodium falciparumSURFIN4.1is a putative ligand expressed on the merozoite and likely on the infected red blood cell, whose gene was suggested to be under directional selection in... Jesse N. Gitaka, Mika Takeda, Masatsugu Kimura, Zulkarnain Md Idris, Chim W. Chan, James Kongere, Kazuhide Yahata, Francis W. Muregi, Yoshio Ichinose, Akira Kaneko and Osamu Kaneko Malaria Journal201716:98 Artemisinin resistance has been reported in Greater Mekong Sub-region countries, including Myanmar. After discovery of artemisinin resistance marker (K13), molecular surveillance on artemisinin resistance in e... Myat Htut Nyunt, Bo Wang, Khin Myo Aye, Kyin Hla Aye, Jin-Hee Han, Seong-Kyun Lee, Kay Thwe Han, Ye Htut and Eun-Taek Han Malaria Journal201716:97 Malaria rapid diagnostic tests (RDTs) enable point-of-care testing to be nearly as sensitive and specific as reference microscopy. The Senegal National Malaria Control Programme introduced RDTs in 2007, along ... Julie Thwing, Fatou Ba, Alou Diaby, Younouss Diedhiou, Assane Sylla, Guelaye Sall, Mame Birame Diouf, Alioune Badara Gueye, Seynabou Gaye, Medoune Ndiop, Moustapha Cisse, Daouda Ndiaye and Mady Ba Malaria Journal201716:95 Malaria control interventions have led to a decline in transmission intensity in many endemic areas, and resulted in elimination in some areas. This decline, however, will lead to delayed acquisition of protec... Henrietta E. Mensah-Brown, James Abugri, Kwaku P. Asante, Duah Dwomoh, David Dosoo, Frank Atuguba, David J. Conway and Gordon A. Awandare Malaria Journal201716:96 Insecticide-treated clothing (ITC) has long been used for military and outdoor recreational purposes and there is substantial evidence to show that it can protect against arthropod biting. As a complementary v... Alison F. Crawshaw, Thae Maung Maung, Muhammad Shafique, Nyan Sint, Sarala Nicholas, Michelle S. Li, Arantxa Roca-Feltrer and Jeffrey Hii Malaria Journal201716:92 The Democratic Republic of Congo (DRC) is one of the two most leading contributors to the global burden of disease due to malaria. This paper describes the malaria testing and treatment market in the nation?s ... Godéfroid Mpanya, Antoinette Tshefu and Joris Losimba Likwela Malaria Journal201716:94 This study examined the acceptability, durability and bio-efficacy of pyrethroid-impregnated durable lining (DL) over a three-year period post-installation in residential homes across Papua New Guinea (PNG). Joseph J. Kuadima, Lincoln Timinao, Laura Naidi, Anthony Tandrapah, Manuel W. Hetzel, Cyrille Czeher and Justin Pulford Malaria Journal201716:93 Understanding biting distribution of potentially infectious (parous) mosquitoes at various hours of the night would be useful in establishing the likely impact of bed nets on malaria transmission. Bed nets are... Masabho P. Milali, Maggy T. Sikulu-Lord and Nicodem J. Govella Malaria Journal201716:91 The widespread availability of next generation genome sequencing technologies has enabled a wide range of variant detection applications, especially in cancer and inborn genetic disorders. For model systems an... Jeremy A. Horst, Wesley Wu and Joseph L. DeRisi Malaria Journal201716:90 Following anti-malarial drug treatment asexual malaria parasite killing and clearance appear to be first order processes. Damaged malaria parasites in circulating erythrocytes are removed from the circulation ... Nicholas J. White Malaria Journal201716:88 Early indication of an emerging malaria epidemic can provide an opportunity for proactive interventions. Challenges to the identification of nascent malaria epidemics include obtaining recent epidemiological s... Christopher L. Merkord, Yi Liu, Abere Mihretie, Teklehaymanot Gebrehiwot, Worku Awoke, Estifanos Bayabil, Geoffrey M. Henebry, Gebeyaw T. Kassa, Mastewal Lake and Michael C. Wimberly Malaria Journal201716:89 Anophelesmosquitoes are the only vectors of human malaria.Anophelesspecies use standing water as breeding sites. Human activities, like the creation of an artificial lake during the... Moreno S. Rodrigures, Elis P. Batista, Alexandre A. Silva, Fábio M. Costa, Verissimo A. S. Neto and Luiz Herman S. Gil Malaria Journal201716:87 Significant reductions in malaria transmission have been achieved over the last 15 years with elimination occurring in a small number of countries, however, increasing drug and insecticide resistance threatens... Michael Coleman, Janet Hemingway, Katherine Ann Gleave, Antoinette Wiebe, Peter W. Gething and Catherine L. Moyes Malaria Journal201716:86 Many of the mosquito species responsible for malaria transmission belong to a sibling complex; a taxonomic group of morphologically identical, closely related species. Sibling species often differ in several i... Antoinette Wiebe, Joshua Longbottom, Katherine Gleave, Freya M. Shearer, Marianne E. Sinka, N. Claire Massey, Ewan Cameron, Samir Bhatt, Peter W. Gething, Janet Hemingway, David L. Smith, Michael Coleman and Catherine L. Moyes Malaria Journal201716:85 The growing resistance ofPlasmodium falciparumto sulfadoxine?pyrimethamine (SP) treatment for uncomplicated malaria led to a recommendation by the World Health Organization for the use of artemisinin-based comb... Chikondi A. Mwendera, Christiaan de Jager, Herbert Longwe, Kamija Phiri, Charles Hongoro and Clifford M. Mutero Malaria Journal201716:84 The widespread emergence of anti-malarial drug resistance has necessitated the discovery of novel anti-malarial drug candidates. In this study, chloroquine derivatives were evaluated for the improved anti-mala... Seon-Ju Yeo, Dong-Xu Liu, Hak Sung Kim and Hyun Park Malaria Journal201716:80 A novel, insecticide-treated, durable wall lining (ITWL), which mimics indoor residual spraying (IRS), has been developed to provide prolonged vector control when fixed to the inner walls of houses. PermaNet®ITW... Robert Malima, Basiliana Emidi, Louisa A. Messenger, Richard M. Oxborough, Bernard Batengana, Wema Sudi, Sophie Weston, George Mtove, Joseph P. Mugasa, Franklin W. Mosha, Mark W. Rowland and William Kisinza Malaria Journal201716:82 Despite emerging drug resistance in Cambodia, artemisinin-based combination therapy (ACT) is still the most efficacious therapy. ACT is available free of charge in the Cambodian public sector and at a subsidiz... Jesse Verschuere, Tom Decroo, Dara Lim, Jean-Marie Kindermans, Chea Nguon, Rekol Huy, Yasmine Alkourdi, Koen Peeters Grietens and Charlotte Gryseels Malaria Journal201716:81 The role of zoos in conservation programmes has increased significantly in last decades, and the health of captive animals is essential to guarantee success of such programmes.However, zoo birds suffer from p... Carolina Romeiro Fernandes Chagas, Gediminas Valki?nas, Lilian de Oliveira Guimarães, Eliana Ferreira Monteiro, Fernanda Junqueira Vaz Guida, Roseli França Simões, Priscila Thihara Rodrigues, Expedito José de Albuquerque Luna and Karin Kirchgatter Malaria Journal201716:83 ThePlasmodiumgenome encodes for a number of 6-Cys proteins that contain a module of six cysteine residues forming three intramolecular disulphide bonds. These proteins have been well characterized at transmissi... Gourab Paul, Arunaditya Deshmukh, Inderjeet Kaur, Sumit Rathore, Surbhi Dabral, Ashutosh Panda, Susheel Kumar Singh, Asif Mohmmed, Michael Theisen and Pawan Malhotra Malaria Journal201716:79 To increase the effectiveness of insecticide-treated nets (ITN) in areas of high resistance, new long-lasting insecticidal nets (LLINs) called new-generation nets have been developed. These nets are treated wi... Marius Allossogbe, Virgile Gnanguenon, Boulais Yovogan, Bruno Akinro, Rodrigue Anagonou, Fiacre Agossa, André Houtoukpe, Germain Gil Padonou and Martin Akogbeto Malaria Journal201716:77 Transfusion-transmitted (TT) malaria is an alternative infection route that has gained little attention from authorities, despite representing a life-threatening condition. There has been no systematic review ... Regina M. Alho, Kim Vinícius Amaral Machado, Fernando F. A. Val, Nelson A. Fraiji, Marcia A. A. Alexandre, Gisely C. Melo, Judith Recht, André M. Siqueira, Wuelton M. Monteiro and Marcus V. G. Lacerda Malaria Journal201716:78 Plasmodium vivaxinfection is known to be rare in West/Central Africa, the most accepted explanation being the lack of expression of erythroid Duffy antigen in the local human populati... Gianluca Russo, Giovanni Faggioni, Giacomo Maria Paganotti, Ghyslaine Bruna Djeunang Dongho, Alice Pomponi, Riccardo De Santis, Gianpiero Tebano, Mpoame Mbida, Martin Sanou Sobze, Vincenzo Vullo, Giovanni Rezza and Florigio Romano Lista Malaria Journal201716:74 The spread of artemisinin-resistance inPlasmodium falciparumis a threat to current global malaria control initiatives. Targeted malaria treatment (TMT), which combines mass anti-malarial administration with con... Kate Sahan, Christopher Pell, Frank Smithuis, Aung Kyaw Phyo, Sai Maung Maung, Chanida Indrasuta, Arjen M. Dondorp, Nicholas J. White, Nicholas P. J. Day, Lorenz von Seidlein and Phaik Yeong Cheah Malaria Journal201716:75 Temperature plays a crucial role in the life history of insects. Recent climate change research has highlighted the importance of elevated temperature on malaria vector distribution. This study aims to examine... Shüné V. Oliver and Basil D. Brooke Malaria Journal201716:73 In Uganda, referral of sick children seeking care at public health facilities is poor and widely reported. However, studies focusing on the private health sector are scanty. The main objective of this study wa... Anthony K. Mbonye, Esther Buregyeya, Elizeus Rutebemberwa, Siân E. Clarke, Sham Lal, Kristian S. Hansen, Pascal Magnussen and Philip LaRussa Malaria Journal201716:76 The use of a malaria early warning system (MEWS) to trigger prompt public health interventions is a key step in adding value to the epidemiological data routinely collected by sentinel surveillance systems. Florian Girond, Laurence Randrianasolo, Lea Randriamampionona, Fanjasoa Rakotomanana, Milijaona Randrianarivelojosia, Maherisoa Ratsitorahina, Télesphore Yao Brou, Vincent Herbreteau, Morgan Mangeas, Sixte Zigiumugabe, Judith Hedje, Christophe Rogier and Patrice Piola Malaria Journal201716:72 Establishing in vitroPlasmodium falciparumculture lines from patient parasite isolates can offer deeper understanding of geographic variations of drug sensitivity and mechanisms of malaria pathogenesis and imm... Sixbert I. Mkumbaye, Daniel T. R. Minja, Jakob S. Jespersen, Michael Alifrangis, Reginald A. Kavishe, Steven B. Mwakalinga, John P. Lusingu, Thor G. Theander, Thomas Lavstsen and Christian W. Wang Malaria Journal201716:69 People living in malaria endemic areas acquire protection from severe malaria quickly, but protection from clinical disease and control of parasitaemia is acquired only after many years of repeated infections.... Isaac Ssewanyana, Emmanuel Arinaitwe, Joaniter I. Nankabirwa, Adoke Yeka, Richard Sullivan, Moses R. Kamya, Philip J. Rosenthal, Grant Dorsey, Harriet Mayanja-Kizza, Chris Drakeley, Bryan Greenhouse and Kevin K. A. Tetteh Malaria Journal201716:67 Non-human primates (NHPs) as a source forPlasmodiuminfections in humans are a challenge for malaria elimination. In Brazil, two species ofPlasmodiumhave been described infecting NHPs,Plasmodium brasilianuma... Denise A. M. Alvarenga, Anielle Pina-Costa, Cesare Bianco, Silvia B. Moreira, Patricia Brasil, Alcides Pissinatti, Claudio T. Daniel-Ribeiro and Cristiana F. A. Brito Malaria Journal201716:71 A key component of malaria elimination campaigns is the identification and targeting of high risk populations. To characterize high risk populations in north central Namibia, a prospective health facility-bas... Jennifer L. Smith, Joyce Auala, Erastus Haindongo, Petrina Uusiku, Roly Gosling, Immo Kleinschmidt, Davis Mumbengegwi and Hugh J. W. Sturrock Malaria Journal201716:70 Scale-up of malaria prevention and treatment needs to continue but national strategies and budget allocations are not always evidence-based. This article presents a new modelling tool projecting malaria infect... Matthew Hamilton, Guy Mahiane, Elric Werst, Rachel Sanders, Olivier Briët, Thomas Smith, Richard Cibulskis, Ewan Cameron, Samir Bhatt, Daniel J. Weiss, Peter W. Gething, Carel Pretorius and Eline L. Korenromp Malaria Journal201716:68 Malaria is one of the most prevalent parasitic diseases in the world and represents a threat to travellers visiting endemic areas. Chemoprophylaxis is the prevention measure used in travel medicine, avoiding c... Tânia do Socorro Souza Chaves, Wuelton Marcelo Monteiro, Jessé Reis Alves, Marcus Lacerda and Marta Heloisa Lopes Malaria Journal201716:64 The reproductive success and population dynamics, ofAnophelesmalaria mosquitoes is strongly influenced by the oviposition site selection of gravid females. Mosquitoes select oviposition sites at different spati... Yelfwagash Asmare, Sharon R. Hill, Richard J. Hopkins, Habte Tekie and Rickard Ignell Malaria Journal201716:65 Malaria control and elimination are challenged by diversity and complexity of the determinants on the international border in the Great Mekong Sub-region. Hekou, a Chinese county on the China?Vietnam border, w... Jian-Wei Xu, Jian-Jie Li, Hong-Ping Guo, Shu-Wei Pu, Shu-Mei Li, Rong-Hua Wang, Hui Liu and Wei-Jia Wang Malaria Journal201716:66 Malariometric information is needed to decide how to introduce malaria vaccines and evaluate their impact in sub-Saharan African countries. Aldiouma Diallo, Ali Sié, Sodiomon Sirima, Khadime Sylla, Mahmadou Ndiaye, Mamadou Bountogo, Espérance Ouedraogo, Roger Tine, Assane Ndiaye, Boubacar Coulibaly, Alphonse Ouedraogo, Babacar Faye, El Hadji Ba, Guillaume Compaore, Alfred Tiono, Cheikh Sokhna? Malaria Journal201716:63 Artemisinin-based combination therapy is the recommended first-line treatment for uncomplicated falciparum malaria worldwide. However, recent studies conducted in Mali showed an increased frequency of recurren... Souleymane Dama, Hamidou Niangaly, Amed Ouattara, Issaka Sagara, Sekou Sissoko, Oumar Bila Traore, Amadou Bamadio, Niawanlou Dara, Moussa Djimde, Mohamed Lamine Alhousseini, Siaka Goita, Hamma Maiga, Antoine Dara, Ogobara K. Doumbo and Abdoulaye A. Djimde Malaria Journal201716:59 Malaria is a notifiable disease in the Netherlands, a non-endemic country. Imported malaria infections occur regularly among travellers, migrants and visitors. Surveillance data were analysed from 2008 to 2015... Brechje de Gier, Franciska S. T. Suryapranata, Mieke Croughs, Perry J. J. van Genderen, Monique Keuter, Leo G. Visser, Michele van Vugt and Gerard J. B. Sonder Plasmodium vivaxis the second most important human malaria parasite, widely spread across the world. This parasite is associated with important issues in the process toward malaria el... Fatimata Sow, Guillaume Bonnot, Bilal Rabah Ahmed, Sidi Mohamed Diagana, Hachim Kebe, Mohamedou Koita, Ba Malado Samba, Said K. Al-Mukhaini, Majed Al-Zadjali, Seif S. Al-Abri, Osama A. M. Ali, Abdallah M. Samy, Muzamil Mahdi Abdel Hamid, Musab M. Ali Albsheer, Bruno Simon, Anne-Lise Bienvenu? Malaria Journal201716:61 Recent anti-malarial resistance monitoring in Angola has shown efficacy of artemether?lumefantrine (AL) in certain sites approaching the key 90% lower limit of efficacy recommended for artemisinin-based combin... Mateusz M. Plucinski, Pedro Rafael Dimbu, Aleixo Panzo Macaia, Carolina Miguel Ferreira, Claudete Samutondo, Joltim Quivinja, Marília Afonso, Richard Kiniffo, Eliane Mbounga, Julia S. Kelley, Dhruviben S. Patel, Yun He, Eldin Talundzic, Denise O. Garrett, Eric S. Halsey, Venkatachalam Udhayakumar? Malaria Journal201716:62 Diagnosis ofPlasmodium falciparumis often based on detection of histidine-rich protein 2 (HRP2) in blood. Most HRP2-based assays have high sensitivity and specificity; however, authors have suggested that antib... Diane Wallace Taylor, Naveen Bobbili, Vedbar S. Khadka, Isabella A. Quakyi and Rose G. F. Leke Malaria Journal201716:58 Shandong Province experienced a declining malaria trend of local-acquired transmission, but the increasing imported malaria remains a challenge. Therefore, understanding the epidemiological characteristics of ... Xiangli Kong, Xin Liu, Hong Tu, Yan Xu, Jianbing Niu, Yongbin Wang, Changlei Zhao, Jingxuan Kou and Jun Feng Malaria Journal201716:55 Assessing the essential components of ?1-3-7? strategy along the China?Myanmar border is critical to identify gaps and challenges to support evidence-based decision making. Duoquan Wang, Chris Cotter, Xiaodong Sun, Adam Bennett, Roly D. Gosling and Ning Xiao Malaria Journal201716:54 Cambodia has seen a marked reduction in the incidence ofPlasmodium falciparumover the past decade without a corresponding decline inPlasmodium vivaxincidence. It is unknown to what extent local transmission i... Rupam Tripura, Thomas J. Peto, Christianne C. Veugen, Chea Nguon, Chan Davoeung, Nicola James, Mehul Dhorda, Richard J. Maude, Jureeporn Duanguppama, Krittaya Patumrat, Mallika Imwong, Lorenz von Seidlein, Martin P. Grobusch, Nicholas J. White and Arjen M. Dondorp Malaria Journal201716:56 When discussing the relationship between meteorological factors and malaria, previous studies mainly focus on the interaction between different climatic factors, while the possible interaction within one parti... Yunyun Wu, Zhijiao Qiao, Nan Wang, Hongjie Yu, Zijian Feng, Xiaosong Li and Xing Zhao Malaria Journal201716:53 Malaria remains one of the most serious infections for travellers to tropical countries. Due to the lack of harmonized guidelines a large variety of treatment regimens is used in Europe to treat severe malaria. Florian Kurth, Michel Develoux, Matthieu Mechain, Denis Malvy, Jan Clerinx, Spinello Antinori, Ida E. Gjørup, Joaquím Gascon, Kristine Mørch, Emanuele Nicastri, Michael Ramharter, Alessandro Bartoloni, Leo Visser, Thierry Rolling, Philipp Zanger, Guido Calleri? Malaria Journal201716:57 Although severe malaria byPlasmodium vivaxhas been increasingly reported, there are marked variations in the type and rate of the complications by geographic area. This is possibly because of the presence of co... Jae Hyoung Im, Hea Yoon Kwon, JiHyeon Baek, Seong Wook Park, Areum Durey, Kyung Hee Lee, Moon-Hyun Chung and Jin-Soo Lee Malaria Journal201716:51 Concern exists about the safety of iron supplementation given to individuals in malarious areas. The possible unfavourable impact of iron supplementation on malaria might be less when slow-release iron compoun... Margaretta A. Prasetyani, Quirijn de Mast, Robel Afeworki, Maria M. M. Kaisar, Difa Stefanie, Erliyani Sartono, Taniawati Supali and André J. van der Ven Malaria Journal201716:50 Eliciting adverse event (AE) and non-study medication data reports from clinical research participants is integral to evaluating drug safety. However, using different methods to question participants yields i... Nyaradzo Mandimika, Karen I. Barnes, Clare I. R. Chandler, Cheryl Pace and Elizabeth N. Allen Malaria Journal201716:52 Very limited studies on Health Impact Assessment (HIA) of Water Development Projects (WDP) in relation to mosquito-borne diseases have been carried out in India. The current study focuses on using HIA as a too... Anushrita, B. N. Nagpal, Neera Kapoor, Aruna Srivastava, Rekha Saxena, Shailendra Singh, Sanjeev Gupta, Sompal Singh, Kumar Vikram and Neena Valecha Malaria Journal201716:47 It is widely acknowledged that modifications to existing control interventions are required if South Africa is to achieve malaria elimination. Targeting indoor residual spraying (IRS) to areas where cases have... Joseph Biggs, Jaishree Raman, Jackie Cook, Khumbulani Hlongwana, Chris Drakeley, Natashia Morris, Ishen Serocharan, Eunice Agubuzo, Philip Kruger, Aaron Mabuza, Alpheus Zitha, Elliot Machaba, Maureen Coetzee and Immo Kleinschmidt Malaria Journal201716:48 The impact of urbanization and population density on childhoodPlasmodium falciparumparasite prevalence rates in Africa Although malaria has been traditionally regarded as less of a problem in urban areas compared to neighbouring rural areas, the risk of malaria infection continues to exist in densely populated, urban areas of ... Caroline W. Kabaria, Marius Gilbert, Abdisalan M. Noor, Robert W. Snow and Catherine Linard Malaria Journal201716:49 Artemisinin-based therapy is the current standard treatment for non-severe malaria due toPlasmodium falciparum.The potential for asymptomatic liver toxicity of this therapy and its implication in clinical prac... André Silva-Pinto, Rogério Ruas, Francisco Almeida, Raquel Duro, André Silva, Cândida Abreu and António Sarmento Malaria Journal201716:43 Recently published data suggest that artemisinin derivatives and synthetic peroxides, such as the ozonides OZ277 and OZ439, have a similar mode of action. Here the cross-resistance of OZ277 and OZ439 and four ... Fabian Baumgärtner, Joëlle Jourdan, Christian Scheurer, Benjamin Blasco, Brice Campo, Pascal Mäser and Sergio Wittlin Malaria Journal201716:45 Short Message Service (SMS) reminders have been suggested as a potential intervention for improving adherence to medications and health facility attendance. Ambrose O. Talisuna, Amos Oburu, Sophie Githinji, Josephine Malinga, Beatrice Amboko, Philip Bejon, Caroline Jones, Robert W. Snow and Dejan Zurovac Malaria Journal201716:46 Guidelines in several European countries recommend standby emergency treatment (SBET) for travellers to regions with low or medium malaria transmission instead of continuous chemoprophylaxis: travellers are ad... Christof D. Vinnemeier, Camilla Rothe, Benno Kreuels, Marylyn M. Addo, Sabine Vygen-Bonnet, Jakob P. Cramer and Thierry Rolling Malaria Journal201716:44 The clinical outcome of malaria depends on the delicate balance between pro-inflammatory and immunomodulatory cytokine responses triggered during infection. Despite the numerous reports on characterization of ... Natália Satchiko Hojo-Souza, Dhelio Batista Pereira, Fernanda Sumika Hojo de Souza, Tiago Antônio de Oliveira Mendes, Mariana Santos Cardoso, Mauro Shugiro Tada, Graziela Maria Zanini, Daniella Castanheira Bartholomeu, Ricardo Toshio Fujiwara and Lilian Lacerda Bueno Malaria Journal201716:42 Anopheles arabiensisis one of the major malaria vectors that put millions of people in endemic countries at risk. Mass-rearing of this mosquito is crucial for strategies that use ster... Wadaka Mamai, Nanwintoum S. Bimbile-Somda, Hamidou Maiga, José Guillermo Juarez, Zaynab A. I. Muosa, Adel Barakat Ali, Rosemary Susan Lees and Jeremie R. L. Gilles Malaria Journal201716:41 The impact of sulfadoxine?pyrimethamine (SP) used as intermittent preventive treatment during pregnancy (IPTp-SP) on mutant parasite selection has been poorly documented in Burkina Faso. This study sought firs... Mamoudou Cisse, Gordon A. Awandare, Alamissa Soulama, Halidou Tinto, Marie-Pierre Hayette and Robert T. Guiguemdé Malaria Journal201716:38 Maize cultivation contributes to the prevalence of malaria mosquitoes and exacerbates malaria transmission in sub-Saharan Africa. The pollen from maize serves as an important larval food source forAnophelesmosq... Betelehem Wondwosen, Sharon R. Hill, Göran Birgersson, Emiru Seyoum, Habte Tekie and Rickard Ignell Malaria Journal201716:39 Appropriate diagnosis and treatment are essential for reducing malaria mortality. A cross-sectional outpatient health facility (HF) survey was conducted in southern Malawi from January to March 2015 to determi... Ruth J. Namuyinga, Dyson Mwandama, Dubulao Moyo, Austin Gumbo, Peter Troell, Miwako Kobayashi, Monica Shah, Andrew Bauleni, Jodi Vanden Eng, Alexander K. Rowe, Don P. Mathanga and Laura C. Steinhardt Malaria Journal201716:40 B-cells are essential in immunity against malaria, but which sub-sets of B-cells specifically recognizePlasmodium falciparumand when they appear is still largely unknown. Allan Lugaajju, Sreenivasulu B. Reddy, Mats Wahlgren, Fred Kironde and Kristina E. M. Persson Malaria Journal201716:37 Malaria is a major public health problem and an important cause of maternal and infant morbidity in sub-Saharan Africa, including Ethiopia. Early and accurate diagnosis of malaria with effective treatment is t... Banchamlak Tegegne, Sisay Getie, Wossenseged Lemma, Abu Naser Mohon and Dylan R. Pillai Malaria Journal201716:34 Glucose-6-phosphate dehydrogenase (G6PD) deficiency is an X-linked hereditary enzymatic abnormality that affects more than 400 million people worldwide. Most deficient individuals do not manifest any symptoms;... Beatriz Galatas, Lurdes Mabote, Wilson Simone, Gloria Matambisso, Lidia Nhamussua, María del Mar Mañú-Pereira, Clara Menéndez, Francisco Saute, Eusebio Macete, Quique Bassat, Pedro Alonso and Pedro Aide Malaria Journal201716:36 In addition to mass distribution campaigns, the World Health Organization (WHO) recommends the continuous distribution of long-lasting insecticidal nets (LLINs) to all pregnant women attending antenatal care (... Katherine Theiss-Nyland, Michael Lynch and Jo Lines Malaria Journal201615:255 Malaria is causing more than half of a million deaths and 214 million clinical cases annually. Despite tremendous efforts for the control of malaria, the global morbidity and mortality have not been significan... Bushra Hafeez Kiani, John Suberu and Bushra Mirza Malaria Journal201615:252 Mosquito habitat-association studies are an important basis for disease control programmes and/or vector distribution models. However, studies do not explicitly account for incomplete detection during larval p... Matthew Low, Admasu Tassew Tsegaye, Rickard Ignell, Sharon Hill, Rasmus Elleby, Vilhelm Feltelius and Richard Hopkins Malaria Journal201615:253 The indigenous Batwa of southwestern Uganda are among the most highly impoverished populations in Uganda, yet there is negligible research on the prevalence of malaria in this population.Plasmodium falciparumma... Blánaid Donnelly, Lea Berrang-Ford, Jolène Labbé, Sabastian Twesigomwe, Shuaib Lwasa, Didacus B. Namanya, Sherilee L. Harper, Manisha Kulkarni, Nancy A. Ross and Pascal Michel Malaria Journal201615:254 Although malaria decline has been observed in most sub-Saharan African countries, the disease still represents a significant public health burden in Tanzania. There are contradictions on the effect of ownershi... Majige Selemani, Amina S. Msengwa, Sigilbert Mrema, Amri Shamte, Michael J. Mahande, Karen Yeates, Maurice C. Y. Mbago and Angelina M. Lutambi Malaria Journal201615:257 Species of avian malaria parasites (Plasmodium) are widespread, but their virulence has been insufficiently investigated, particularly in wild birds. During avian malaria, several cycles of tissue merogony occur,... Mikas Ilg?nas, Dovil? Bukauskait?, Vaidas Palinauskas, Tatjana A. Iezhova, Nora Dinhopl, Nora Nedorost, Christiane Weissenbacher-Lang, Herbert Weissenböck and Gediminas Valki?nas Malaria Journal201615:256 The approach of using transgenic rodent malaria parasites to assess the immune system?s response to antigenic targets from a human malaria parasite has been shown to be useful for preclinical evaluation of new... Masanori Mizutani, Shinya Fukumoto, Adam Patrice Soubeiga, Akira Soga, Mitsuhiro Iyori and Shigeto Yoshida Malaria Journal201615:251 In Cambodia, behaviour change communication (BCC) represents an integral component of malaria efforts aimed at fighting artemisinin resistant parasites and achieving elimination. The multi-pronged BCC interven... Sara E. Canavati, Celine Zegers de Beyl, Po Ly, Muhammad Shafique, Thavrin Boukheng, Chandary Rang, Maxine Anne Whittaker, Arantxa Roca-Feltrer and David Sintasath Malaria Journal201615:249 Malaria intervention in Ethiopia has been strengthened significantly in the past decade. The Ethiopian government recently stratified the country based upon annual parasite incidence into malaria free, low, mo... Guofa Zhou, Delenasaw Yewhalaw, Eugenia Lo, Daibin Zhong, Xiaoming Wang, Teshome Degefa, Endalew Zemene, Ming-chieh Lee, Estifanos Kebede, Kora Tushune and Guiyun Yan Malaria Journal201615:250 In Uganda, over half of under-five child mortality is attributed to three infectious diseases: malaria, pneumonia and diarrhoea. Integrated community case management (iCCM) trains village health workers (VHWs)... Lacey English, James S. Miller, Rapheal Mbusa, Michael Matte, Jessica Kenney, Shem Bwambale, Moses Ntaro, Palka Patel, Edgar Mulogo and Geren S. Stone Malaria Journal201615:247 The asexual intra-erythrocytic multiplication of the malaria parasitePlasmodium falciparumis regulated by various molecular mechanisms. In eukaryotic cells, protein kinases are known to play key roles in cell c... Kossiwa Bandje, Bernina Naissant, Pascal Bigey, Murielle Lohezic, Marlène Vayssières, Magali Blaud, Laetitia Kermasson, José-Juan Lopez-Rubio, Gordon Langsley, Catherine Lavazec, Philippe Deloron and Anaïs Merckx Malaria Journal201615:248 The World Health Organization (WHO) cone bioassay plays an integral role in the evaluation of the efficacy of long-lasting insecticidal nets as well as insecticides used in indoor residual spraying. The test i... Henry F. Owusu and Pie Müller Malaria Journal201615:243 Pharmacokinetic properties of intramuscular versus oral syrup paracetamol in Plasmodium falciparum malariaFever is an inherent symptom of malaria in both adults and children. Paracetamol (acetaminophen) is the recommended antipyretic as it is inexpensive, widely available and has a good safety profile, but patient... Thanaporn Wattanakul, Pramote Teerapong, Katherine Plewes, Paul N. Newton, Wirongrong Chierakul, Kamolrat Silamut, Kesinee Chotivanich, Ronnatrai Ruengweerayut, Nicholas J. White, Arjen M. Dondorp and Joel Tarning Malaria Journal 2016 15:244 Risk factors of malaria in children under the age of five years old in UgandaMalaria is the leading cause of morbidity in Uganda with 90?95 % of the population at risk and it contributing to approximately 13 % of under-five mortality. The aim of this study was to investigate the relati... Danielle Roberts and Glenda Matthews Malaria Journal 2016 15:246 Heterogeneous malaria transmission in long-term Afghan refugee populations: a cross-sectional study in five refugee camps in northern PakistanAfghan refugees in northern Pakistan have been resident for over 30 years and current information on malaria in this population is sparse. Understanding malaria risk and distribution in refugee camps is import... Sobia Wahid, Gillian H. Stresman, Syed Sajid Kamal, Nuno Sepulveda, Immo Kleinschmidt, Teun Bousema and Chris Drakeley Malaria Journal 2016 15:245 History of malaria treatment as a predictor of subsequent subclinical parasitaemia: a cross-sectional survey and malaria case records from three villages in Pailin, western CambodiaTreatment of the sub-clinical reservoir of malaria, which may maintain transmission, could be an important component of elimination strategies. The reliable detection of asymptomatic infections with low levels... Thomas J. Peto, Sabine E. Kloprogge, Rupam Tripura, Chea Nguon, Nou Sanann, Sovann Yok, Chhouen Heng, Cholrawee Promnarate, Jeremy Chalk, Ngak Song, Sue J. Lee, Yoel Lubell, Mehul Dhorda, Mallika Imwong, Nicholas J. White, Lorenz von Seidlein? Malaria Journal 2016 15:240 Clustering and genetic differentiation of the normocyte binding protein (nbpxa) of Plasmodium knowlesi clinical isolates from Peninsular Malaysia and Malaysia BorneoThe zoonotic malaria parasite Plasmodium knowlesi has become an emerging threat to South East Asian countries particular in Malaysia. A recent study from Sarawak (Malaysian Borneo) discovered two distinct normocy... Md Atique Ahmed, Mun Yik Fong, Yee Ling Lau and Ruhani Yusof Malaria Journal 2016 15:241 Defining rules of CD8+ T cell expansion against pre-erythrocytic Plasmodium antigens in sporozoite-immunized miceWhole Plasmodium sporozoites serve as both experimental tools and potentially as deployable vaccines in the fight against malaria infection. Live sporozoites infect hepatocytes and induce a diverse repertoire of ... Zachary P. Billman, Arnold Kas, Brad C. Stone and Sean C. Murphy Malaria Journal 2016 15:238 Determination of the foraging behaviour and blood meal source of malaria vector mosquitoes in Trincomalee District of Sri Lanka using a multiplex real time polymerase chain reaction assayStudies of host preference patterns in blood-feeding anopheline mosquitoes are crucial to incriminating malaria vectors. However, little information is available on host preferences of Anopheles mosquitoes in Sri... Nayana Gunathilaka, Thanuja Denipitiya, Menaka Hapugoda, Wimaladharma Abeyewickreme and Rajitha Wickremasinghe Malaria Journal 2016 15:242 Increasing outdoor host-seeking in Anopheles gambiae over 6 years of vector control on Bioko IslandVector control through indoor residual spraying (IRS) has been employed on Bioko Island, Equatorial Guinea, under the Bioko Island Malaria Control Project (BIMCP) since 2004. This study analyses the change in ... Jacob I. Meyers, Sharmila Pathikonda, Zachary R. Popkin-Hall, Matthew C. Medeiros, Godwin Fuseini, Abrahan Matias, Guillermo Garcia, Hans J. Overgaard, Vani Kulkarni, Vamsi P. Reddy, Christopher Schwabe, Jo Lines, Immo Kleinschmidt and Michel A. Slotman Malaria Journal 2016 15:239 Malaria case clinical profiles and Plasmodium falciparum parasite genetic diversity: a cross sectional survey at two sites of different malaria transmission intensities in RwandaMalaria remains a public health challenge in sub-Saharan Africa with Plasmodium falciparum being the principal cause of malaria disease morbidity and mortality. Plasmodium falciparum v... Fredrick Kateera, Sam L. Nsobya, Stephen Tukwasibwe, Petra F. Mens, Emmanuel Hakizimana, Martin P. Grobusch, Leon Mutesa, Nirbhay Kumar and Michele van Vugt Malaria Journal 2016 15:237 In vivo efficacy of artemether-lumefantrine and artesunate-amodiaquine for uncomplicated Plasmodium falciparum malaria in Malawi, 2014Malaria causes significant morbidity in Malawi, with an estimated 5 million cases in 2014. Artemether-lumefantrine (AL) and artesunate-amodiaquine (ASAQ) are the first- and second-line treatments for uncomplic... Magdalena Paczkowski, Dyson Mwandama, Daniel Marthey, Madalitso Luka, Georgina Makuta, John Sande, Doreen Ali, Peter Troell, Don P. Mathanga and Julie Gutman Malaria Journal 2016 15:236 The need for operational research and capacity-building in support of the Global Technical Strategy for Malaria 2016?2030 Andrew Ramsay, Piero Olliaro and John C. Reeder Malaria Journal 2016 15:235 Visualization of house-entry behaviour of malaria mosquitoes Malaria mosquitoes often blood feed indoors on human hosts. The mosquitoes predominantly enter houses via open eaves. Host-seeking is odour-driven, and finding a host depends on the quality of the odour plume ... Jeroen Spitzen, Teun Koelewijn, W. Richard Mukabana and Willem Takken Malaria Journal 2016 15:233 Transfusion-transmitted malaria: donor prevalence of parasitaemia and a survey of healthcare workers knowledge and practices in a district hospital in Ghana Transfusion-transmitted malaria (TTM) is a risk of transfusion that has not been well described in malaria endemic regions. The risk of the recipient getting malaria is related to the prevalence of malaria in ... Alex Owusu-Ofori, Dominic Gadzo and Imelda Bates Malaria Journal 2016 15:234 Enhanced transmission of malaria parasites to mosquitoes in a murine model of type 2 diabetes More than half of the world?s population is at risk of malaria and simultaneously, many malaria-endemic regions are facing dramatic increases in the prevalence of type 2 diabetes. Studies in murine malaria mod... Nazzy Pakpour, Kong Wai Cheung and Shirley Luckhart Malaria Journal 2016 15:231 Genomic variation in two gametocyte non-producing Plasmodium falciparum clonal lines Transmission of the malaria parasite Plasmodium falciparum from humans to the mosquito vector requires differentiation of a sub-population of asexual forms replicating within red blood cells into non-dividing mal... Susana Campino, Ernest Diez Benavente, Samuel Assefa, Eloise Thompson, Laura G. Drought, Catherine J. Taylor, Zaria Gorvett, Celine K. Carret, Christian Flueck, Al C. Ivens, Dominic P. Kwiatkowski, Pietro Alano, David A. Baker and Taane G. Clark Malaria Journal 2016 15:229 Assessing the effects of malaria interventions on the geographical distribution of parasitaemia risk in Burkina Faso Burkina Faso conducted its first nationally representative household malaria survey in 2010/2011. The survey collected among others, information on malaria interventions, treatment choices and malaria parasite... Eric Diboulo, Ali Sié and Penelope Vounatsou Malaria Journal 2016 15:228 An ultrasensitive NanoLuc-based luminescence system for monitoring Plasmodium berghei throughout its life cycle Bioluminescence imaging is widely used for cell-based assays and animal imaging studies, both in biomedical research and drug development. Its main advantages include its high-throughput applicability, afforda... Mariana De Niz, Rebecca R. Stanway, Rahel Wacker, Derya Keller and Volker T. Heussler Malaria Journal 2016 15:232 Chronic malaria and hyper-reactive malarial splenomegaly: a retrospective study on the largest series observed in a non-endemic country Chronic malaria is usually defined as a long-term malarial infection in semi-immune subjects, usually without fever or other acute symptoms. The untreated infection may evolve to hyper-reactive malarial spleno... Zeno Bisoffi, Stefania Leoni, Andrea Angheben, Anna Beltrame, Franklyn Esoka Eseme, Federico Gobbi, Claudia Lodesani, Stefania Marocco and Dora Buonfrate Malaria Journal 2016 15:230 Pre-infection administration of asiatic acid retards parasitaemia induction inPlasmodium bergheimurine malaria infected Sprague-Dawley rats Malaria prevention has remained a critical area in the absence of efficacious vaccines against malaria. Drugs currently used as chemotherapeutics are also used in chemoprophylaxis increasing possible drug resi... Greanious Alfred Mavondo, Blessing Nkazimulo Mkhwananzi and Musa Vuyisile Mabandla Malaria Journal 2016 15:226 Determinants of prompt and adequate care among presumed malaria cases in a community in eastern Rwanda: a cross sectional study In order to understand factors influencing fever/malaria management practices among community-based individuals, the study evaluated psychosocial, socio-demographic and environmental determinants of prompt and... Chantal Marie Ingabire, Fredrick Kateera, Emmanuel Hakizimana, Alexis Rulisa, Claude Muvunyi, Petra Mens, Constantianus J. M. Koenraadt, Leon Mutesa, Michele Van Vugt, Bart Van Den Borne and Jane Alaii Malaria Journal 2016 15:227 | 
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