Part 2: New and effective antimalarial drugs in global malaria elimination strategies
The potential elimination of Plasmodium vivax malaria by relapse treatment: insights from a transmission model and surveillance data from NW India.
Roy M, Bouma MJ, Ionides EL, Dhiman RC, Pascual M.PLoS Negl Trop Dis. 2013;7(1):e1979. doi: 10.1371/journal.pntd.0001979.Epub 2013 Jan 10.PMID: 23326611Free PMC Article Similar articles Select item 28381261 94.
Challenges for achieving safe and effective radical cure of Plasmodium vivax: a round table discussion of the APMEN Vivax Working Group.
Thriemer K, Ley B, Bobogare A, Dysoley L, Alam MS, Pasaribu AP, Sattabongkot J, Jambert E, Domingo GJ, Commons R, Auburn S, Marfurt J, Devine A, Aktaruzzaman MM, Sohel N, Namgay R, Drukpa T, Sharma SN, Sarawati E, Samad I, Theodora M, Nambanya S, Ounekham S, Mudin RN, Da Thakur G, Makita LS, Deray R, Lee SE, Boaz L, Danansuriya MN, Mudiyanselage SD, Chinanonwait N, Kitchakarn S, Nausien J, Naket E, Duc TN, Do Manh H, Hong YS, Cheng Q, Richards JS, Kusriastuti R, Satyagraha A, Noviyanti R, Ding XC, Khan WA, Swe Phru C, Guoding Z, Qi G, Kaneko A, Miotto O, Nguitragool W, Roobsoong W, Battle K, Howes RE, Roca-Feltrer A, Duparc S, Bhowmick IP, Kenangalem E, Bibit JA, Barry A, Sintasath D, Abeyasinghe R, Sibley CH, McCarthy J, von Seidlein L, Baird JK, Price RN.
Malar J. 2017 Apr 5;16(1):141. doi: 10.1186/s12936-017-1784-1. Review.
PMID: 28381261Free PMC Article Similar articles Select item 23797843 95.
An LC-MS based study of the metabolic profile of primaquine, an 8-aminoquinoline antiparasitic drug, with an in vitro primary human hepatocyte culture model.
Jin X, Pybus BS, Marcsisin R, Logan T, Luong TL, Sousa J, Matlock N, Collazo V, Asher C, Carroll D, Olmeda R, Walker LA, Kozar MP, Melendez V.Eur J Drug Metab Pharmacokinet.2014 Jun;39(2):139-46.PMID: 23797843Similar articles Select item 30565279 96.
Association between aripiprazole pharmacokinetics and CYP2D6 phenotypes: A systematic review and meta-analysis.
Zhang X, Xiang Q, Zhao X, Ma L, Cui Y.J Clin Pharm Ther. 2018 Dec 18. doi: 10.1111/jcpt.12780. [Epub ahead of print] Review.PMID: 30565279Similar articles Select item 27188854 97.
Pre-clinical evaluation of CYP 2D6 dependent drug-drug interactions between primaquine and SSRI/SNRI antidepressants.
Jin X, Potter B, Luong TL, Nelson J, Vuong C, Potter C, Xie L, Zhang J, Zhang P, Sousa J, Li Q, Pybus BS, Kreishman-Deitrick M, Hickman M, Smith PL, Paris R, Reichard G, Marcsisin SR.Malar J. 2016 May 17;15(1):280. doi: 10.1186/s12936-016-1329-z.PMID: 27188854Free PMC Article Similar articles Select item 27016470 98.
Primaquine pharmacology in the context of CYP 2D6 pharmacogenomics: Current state of the art.
Marcsisin SR, Reichard G, Pybus BS.Pharmacol Ther. 2016 May;161:1-10. doi: 10.1016/j.pharmthera.2016.03.011. Epub 2016 Mar 22. Review.PMID: 27016470Free Article Similar articles Select item 25891812 99.
Killing the hypnozoite--drug discovery approaches to prevent relapse in Plasmodium vivax.
Campo B, Vandal O, Wesche DL, Burrows JN.Pathog Glob Health. 2015 May;109(3):107-22. doi: 10.1179/2047773215Y.0000000013. Epub 2015 Apr 18. Review.PMID: 25891812Free PMC Article Similar articles Select item 30400893 100.
Tafenoquine and primaquine do not exhibit clinical neurologic signs associated with central nervous system lesions in the same manner as earlier 8-aminoquinolines.
Berman J, Brown T, Dow G, Toovey S.Malar J. 2018 Nov 6;17(1):407. doi: 10.1186/s12936-018-2555-3. Review.PMID: 30400893Free PMC Article Similar articles
The Use of In Vitro Data and Physiologically-Based Pharmacokinetic Modeling to Predict Drug Metabolite Exposure: Desipramine Exposure in Cytochrome P4502D6 Extensive and Poor Metabolizers Following Administration of Imipramine.
Nguyen HQ, Callegari E, Obach RS.Drug Metab Dispos. 2016 Oct;44(10):1569-78. doi: 10.1124/dmd.116.071639. Epub 2016 Jul 20.PMID: 27440861Similar articles Select item 25759576 102.
Oral lipid-based nanoformulation of tafenoquine enhanced bioavailability and blood stage antimalarial efficacy and led to a reduction in human red blood cell loss in mice.
Melariri P, Kalombo L, Nkuna P, Dube A, Hayeshi R, Ogutu B, Gibhard L, deKock C, Smith P, Wiesner L, Swai H.Int J Nanomedicine. 2015 Feb 20;10:1493-503. doi: 10.2147/IJN.S76317. eCollection 2015.PMID: 25759576Free PMC Article Similar articles Select item 29676238 103.
Effect of CYP2D6 Poor Metabolizer Phenotype on Stereoselective Nebivolol Pharmacokinetics.
Vieira CP, Neves DV, Coelho EB, Lanchote VL.Drug Metab Lett. 2018;12(1):68-70. doi: 10.2174/1872312812666180420104945.PMID: 29676238Similar articles Select item 30058787 104.
CYP2D6 basic genotyping as a potential tool to improve the antiemetic efficacy of ondansetron in prophylaxis of postoperative nausea and vomiting.
Niewi?ski PA, Wojciechowski R, ?liwi?ski M, Hurkacz ME, G?owacka K, Orzechowska-Juzwenko K, Wiela-Hoje?ska AK.Adv Clin Exp Med. 2018 Nov;27(11):1499-1503. doi: 10.17219/acem/69451.PMID: 30058787Free Article Similar articles Select item 3542534 105.
Pharmacokinetics of primaquine in patients with P. vivax malaria.
Bhatia SC, Saraph YS, Revankar SN, Doshi KJ, Bharucha ED, Desai ND, Vaidya AB, Subrahmanyam D, Gupta KC, Satoskar RS.Eur J Clin Pharmacol.1986;31(2):205-10. PMID: 3542534Similar articles Select item 28836792 106.
Galactose-Anchored Gelatin Nanoparticles for Primaquine Delivery and Improved Pharmacokinetics: A Biodegradable and Safe Approach for Effective Antiplasmodial Activity against P. falciparum 3D7 and in Vivo Hepatocyte Targeting.
Kumar H, Gothwal A, Khan I, Nakhate KT, Alexander A, Ajazuddin, Singh V, Gupta U.Mol Pharm. 2017 Oct 2;14(10):3356-3369. doi: 10.1021/acs.molpharmaceut.7b00376. Epub 2017 Sep 11.PMID: 28836792Similar articles Select item 24913163 107.
Scalable preparation and differential pharmacologic and toxicologic profiles of primaquine enantiomers.
Nanayakkara NP, Tekwani BL, Herath HM, Sahu R, Gettayacamin M, Tungtaeng A, van Gessel Y, Baresel P, Wickham KS, Bartlett MS, Fronczek FR, Melendez V, Ohrt C, Reichard GA, McChesney JD, Rochford R, Walker LA.Antimicrob Agents Chemother. 2014 Aug;58(8):4737-44. doi: 10.1128/AAC.02674-13. Epub 2014 Jun 9.PMID: 24913163Free PMC Article Similar articles Select item 29510711 108.
The ethics of using placebo in randomised controlled trials: a case study of a Plasmodium vivax antirelapse trial.
Cheah PY, Steinkamp N, von Seidlein L, Price RN.BMC Med Ethics. 2018 Mar 6;19(1):19. doi: 10.1186/s12910-018-0259-4.PMID: 29510711Free PMC Article Similar articles Select item 10615272 109.
The evolution of tafenoquine--antimalarial for a new millennium?
Peters W.J R Soc Med. 1999 Jul;92(7):345-52. Review. No abstract available. PMID: 10615272Free PMC Article Similar articles Select item 27721533 110.
Evaluation of pharmacokinetics of single-dose chloroquine in malnourished children with malaria- a comparative study with normally nourished children.
Kadam PP, Gogtay NJ, Karande S, Shah V, Thatte UM.Indian J Pharmacol. 2016 Sep-Oct;48(5):498-502.PMID: 27721533Free PMC Article Similar articles Select item 29869298 111.
Application of the Stable Isotope Label Approach in Clinical Development-Supporting Dissolution Specifications for a Commercial Tablet Product with Tafenoquine, a Long Half-life Compound.
Goyal N, Mohamed K, Rolfe K, Sahota S, Ernest T, Duparc S, Taylor M, Casillas L, Koh GCKW.AAPS J. 2018 Jun 4;20(4):74. doi: 10.1208/s12248-018-0234-5.PMID: 29869298Similar articles Select item 22399238 112.
The dopaminergic stabilizer pridopidine is to a major extent N-depropylated by CYP2D6 in humans.
Helldén A, Panagiotidis G, Johansson P, Waters N, Waters S, Tedroff J, Bertilsson L.Eur J Clin Pharmacol. 2012 Sep;68(9):1281-6. doi: 10.1007/s00228-012-1248-z. Epub 2012 Mar 8.PMID: 22399238Similar articles Select item 29317838 113.
Primaquine double dose for 7 days is inferior to single-dose treatment for 14 days in preventingPlasmodium vivax recurrent episodes in Suriname.
Mac Donald-Ottevanger MS, Adhin MR, Jitan JK, Bretas G, Vreden SG.Infect Drug Resist. 2017 Dec 20;11:3-8. doi: 10.2147/IDR.S135897. eCollection 2018.PMID: 29317838Free PMC Article Similar articles Select item 27093859 114.
Differential kinetic profiles and metabolism of primaquine enantiomers by human hepatocytes.
Fasinu PS, Avula B, Tekwani BL, Nanayakkara NP, Wang YH, Bandara Herath HM, McChesney JD, Reichard GA, Marcsisin SR, Elsohly MA, Khan SI, Khan IA, Walker LA.Malar J. 2016 Apr 19;15:224. doi: 10.1186/s12936-016-1270-1.PMID: 27093859Free PMC Article Similar articles Select item 13793053 115.
Mitigation of the haemolytic effect of primaquine and enhancement of its action against exoerythrocytic forms of the Chesson strain of Piasmodium vivax by intermittent regimens of drug administration: a preliminary report.
ALVING AS, JOHNSON CF, TARLOV AR, BREWER GJ, KELLERMEYER RW, CARSON PE.Bull World Health Organ. 1960;22:621-31.PMID: 13793053Free PMC Article Similar articles Select item 22144436 116.
Review: Improving the therapeutic index of 8-aminoquinolines by the use of drug combinations: review of the literature and proposal for future investigations.
Myint HY, Berman J, Walker L, Pybus B, Melendez V, Baird JK, Ohrt C.Am J Trop Med Hyg. 2011 Dec;85(6):1010-4. doi: 10.4269/ajtmh.2011.11-0498. Review.PMID: 22144436Free PMC Article Similar articles Select item 25295216 117.
Antirelapse Efficacy of Various Primaquine Regimens for Plasmodium vivax.
Rajgor DD, Gogtay NJ , Kadam VS, Kocharekar MM, Parulekar MS, Dalvi SS, Vaidya AB , Kshirsagar NA.Malar Res Treat. 2014;2014:347018. doi: 10.1155/2014/347018. Epub 2014 Sep 10.PMID: 25295216Free PMC Article Similar articles Select item 24360370 118.
Single-dose radical cure of Plasmodium vivax: a step closer.
Price RN, Nosten F.Lancet. 2014 Mar 22;383(9922):1020-1. doi: 10.1016/S0140-6736(13)62672-0. Epub 2013 Dec 19. No abstract available. PMID: 24360370Free PMC Article Similar articles Select item 30706164 119.
Effects of MAO-A and CYP450 on primaquine metabolism in healthy volunteers.
Ariffin NM , Islahudin F, Kumolosasi E, Makmor-Bakry M.Parasitol Res. 2019 Jan 31. doi: 10.1007/s00436-019-06210-3. [Epub ahead of print]PMID: 30706164Similar articles Select item 29713556 120.
Relapsing Malaria: A Case Report of Primaquine Resistance.
Dijanic C, Nickerson J, Shakya S, Dijanic A, Fabbri M.Case Rep Infect Dis. 2018 Mar 11;2018:9720823. doi: 10.1155/2018/9720823. eCollection 2018.PMID: 29713556Free PMC Article Similar articles
Chloroquine-Primaquine Therapeutic Efficacy, Safety, and Plasma Levels in Patients with UncomplicatedPlasmodium vivax Malaria in a Colombian Pacific Region.
Mesa-Echeverry E, Niebles-Bolívar M, Tobón-Castaño A.Am J Trop Med Hyg. 2019 Jan;100(1):72-77. doi: 10.4269/ajtmh.18-0655.PMID: 30457097Similar articles Select item 14804087 122.
Primaquine, SN 13272, a new curative agent in vivax malaria; a preliminary report.
Edgcomb jh, arnold j, yount eh jr, alving as, eichelberger l, jeffery gm, eyles d, young md.J Natl Malar Soc. 1950 Dec;9(4):285-92.No abstract available. PMID: 14804087Similar articles Select item 25385861 123.
Performance of BinaxNOW G6PD deficiency point-of-care diagnostic in P. vivax-infected subjects.
Osorio L, Carter N, Arthur P, Bancone G, Gopalan S, Gupta SK, Noedl H, Kochar SK, Kochar DK, Krudsood S, Lacerda MV, Llanos-Cuentas A, Rueangweerayut R, Srinivasan R, Treiber M, Möhrle JJ, Green J.
Am J Trop Med Hyg. 2015 Jan;92(1):22-7. doi: 10.4269/ajtmh.14-0298. Epub 2014 Nov 10.
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A Review of Pharmacogenetics of Antimalarials and Associated Clinical Implications.
Elewa H, Wilby KJ.Eur J Drug Metab Pharmacokinet. 2017 Oct;42(5):745-756. doi: 10.1007/s13318-016-0399-1. Review.PMID: 28070879Similar articles Select item 30229442 125.
Tafenoquine: First Global Approval.
Frampton JE.Drugs. 2018 Sep;78(14):1517-1523. doi: 10.1007/s40265-018-0979-2.PMID: 30229442Similar articles Select item 30380095 126.
Tafenoquine for travelers' malaria: evidence, rationale and recommendations.
Baird JK.J Travel Med. 2018 Jan 1;25(1). doi: 10.1093/jtm/tay110.PMID: 30380095Free PMC Article Similar articles Select item 28350251 127.
Impact of CYP2D6 genotype on amitriptyline efficacy for the treatment of diabetic peripheral neuropathy: a pilot study.
Chaudhry M, Alessandrini M, Rademan J, Dodgen TM, Steffens FE, van Zyl DG, Gaedigk A, Pepper MS.Pharmacogenomics. 2017 Apr;18(5):433-443. doi: 10.2217/pgs-2016-0185. Epub 2017 Mar 28.PMID: 28350251Free Article Similar articles Select item 27072954 128.
Minimization of CYP2D6 Polymorphic Differences and Improved Bioavailability via Transdermal Administration: Latrepirdine Example.
Chew ML, Mordenti J, Yeoh T, Ranade G, Qiu R, Fang J, Liang Y, Corrigan B.Pharm Res. 2016 Aug;33(8):1873-80. doi: 10.1007/s11095-016-1922-4. Epub 2016 Apr 12.PMID: 27072954Similar articles Select item 30670877 129.
CYP2D6-guided opioid therapy improves pain control in CYP2D6 intermediate and poor metabolizers: a pragmatic clinical trial.
Smith DM, Weitzel KW, Elsey AR, Langaee T, Gong Y, Wake DT, Duong BQ, Hagen M, Harle CA, Mercado E, Nagoshi Y, Newsom K, Wright A, Rosenberg EI, Starostik P, Clare-Salzler MJ, Schmidt SO, Fillingim RB, Johnson JA, Cavallari LH.Genet Med. 2019 Jan 23. doi: 10.1038/s41436-018-0431-8. [Epub ahead of print]. PMID: 30670877Similar articles Select item 14945979 130.
Cure of Korean vivax malaria with pamaquine and primaquine.
GARRISON PL, HANKEY DD, COKER WG, DONOVAN WN, JASTREMSKI B, COATNEY GR, ALVING AS, JONES R Jr.J Am Med Assoc. 1952 Aug 23;149(17):1562-3. No abstract available. PMID: 14945979Similar articles Select item 26528073 131.
Phenotypic differences in nebivolol metabolism and bioavailability in healthy volunteers.
Briciu C, Neag M, Muntean D, Bocsan C, Buzoianu A, Antonescu O, Gheldiu AM, Achim M, Popa A, Vlase L.Clujul Med. 2015;88(2):208-13. doi: 10.15386/cjmed-395. Epub 2015 Apr 15.PMID: 26528073Free PMC Article Similar articles Select item 21970596 132.
Pharmacogenetic testing affects choice of therapy among women considering tamoxifen treatment.
Lorizio W, Rugo H, Beattie MS, Tchu S, Melese T, Melisko M, Wu AH, Lawrence HJ, Nikoloff M, Ziv E. Genome Med. 2011 Oct 4;3(10):64. doi: 10.1186/gm280.PMID: 21970596Free PMC Article Similar articles Select item 14419205 133.
Use of quinocide in treatment and prophylaxis of vivax malaria.
LYSENKO AY.Bull World Health Organ. 1960;22:641-62.PMID: 14419205Free PMC Article Similar articles Select item 27223244 134.
Methemoglobinemia Hemotoxicity of Some Antimalarial 8-Aminoquinoline Analogues and Their Hydroxylated Derivatives: Density Functional Theory Computation of Ionization Potentials.
Ding Y, Liu H, Tekwani BL, Nanayakkara NP, Khan IA, Walker LA, Doerksen RJ.
Chem Res Toxicol. 2016 Jul 18;29(7):1132-41. doi: 10.1021/acs.chemrestox.6b00063. Epub 2016 Jul 1.
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Tafenoquine - A Radical Improvement?
White NJ .
N Engl J Med. 2019 Jan 17;380(3):285-286. doi: 10.1056/NEJMe1816383. No abstract available.
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The Associations Between CYP2D6 Metabolizer Status and Pharmacokinetics and Clinical Outcomes of Venlafaxine: A Systematic Review and Meta-Analysis.
Lin XQ, Wang P, Cai WK, Xu GL, Yang M, Zhou MD, Sun M, He F, He GH.
Pharmacopsychiatry. 2018 Nov 28. doi: 10.1055/a-0792-1340. [Epub ahead of print]
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Pentaquine (SN-13,276) a new antimalarial effective in reducing the relapse rate of vivax malaria.
PULLMAN TN, ALVING AS, et al.
Proc Annu Meet Cent Soc Clin Res U S. 1946 Nov 1-2;19:83. No abstract available.
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Pamaquin; curative antimalarial activity in vivax malaria.
BERLINER RW, TAGGART JV, et al.
Fed Proc. 1946;5(1 Pt 2):165. No abstract available.
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Pharmacometric Analyses to Support Early Development Decisions for LY2878735: A Novel Serotonin Norepinephrine Reuptake Inhibitor.
Raddad E, Melhem MR, Sloan-Lancaster JS, Miller JW, Van Wart SA, Rubino CM.
CPT Pharmacometrics Syst Pharmacol. 2013 Aug 21;2:e66. doi: 10.1038/psp.2013.43.
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Study of pentaquine and isopentaquine, therapeutic agents effective in reducing relapse rate in vivax malaria.
ALVING AS.
Abstr Int Congr Trop Med Malar. 1948;56(4th Congr):58. No abstract available.
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Combined quinine-plasmochin treatment of vivax malaria; effect of relapse rate.
MOST H, KANE CA, et al.
Am J Med Sci. 1946 Nov;212(5):550-60. No abstract available.
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Pharmacogenetics of Vascular Risk Factors in Alzheimer's Disease.
Cacabelos R, Meyyazhagan A, Carril JC, Cacabelos P, Teijido Ó.
J Pers Med. 2018 Jan 3;8(1). pii: E3. doi: 10.3390/jpm8010003. Review.
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Combined quinine-plasmochin and quinine-pentaquine treatment of relapsing vivax malaria.
SPICKNALL CG, TERRY LL.
South Med J. 1948 Apr;41(4):338-41. No abstract available.
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Radical cure of relapsing vivax malaria with pentaquine-quinine; a controlled study.
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Studies in human malaria; the therapeutic action of pamaquine against St. Elizabeth strain vivax malaria.
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Am J Hyg. 1949 May;49(3):367-73. No abstract available.
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Pentaquine (SN-13,276) a therapeutic agent effective in reducing the relapse rate in vivax malaria.
ALVING AS, CRAIGE B Jr, et al.
J Clin Invest. 1948 May;27(3 Pt1):25-33. No abstract available.
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Evaluation of pentaquine as a cure of relapsing vivax malaria; a controlled study of 95 cases.
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Bull N Y Acad Med. 1948 Jun;24(6):395. No abstract available.
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Studies in human malaria. XXVII. Observations on the use of pentaquine in the prevention and treatment of Chesson strain vivax malaria.
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Cure of chronic vivax malaria with pentaquine.
COGGESHALL LT, RICE FA.
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Cure of chronic vivax malaria with pentaquine and status of immunity thereafter.
COGGESHALL LT.
Proc Inst Med Chic. 1949 Jun 15;17(15):357. No abstract available.
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Tafenoquine receives regulatory approval in USA for prophylaxis of malaria and radical cure of Plasmodium vivax.
Tan KR, Hwang J.
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On naturalistic pharmacogenetic studies: reply from the authors.
Seip RL, Goethe JW, Schwartz HI, Ruaño G.
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Correction: Variation in Human Cytochrome P-450 Drug-Metabolism Genes: A Gateway to the Understanding of Plasmodium vivax Relapses.
Silvino ACR, Costa GL, Araújo FCF, Ascher DB, Pires DEV, Fontes CJF, Carvalho LH, Brito CFA, Sousa TN.
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Pharmacogenetic comparison of CYP2D6 predictive and measured phenotypes in a South African cohort.
Dodgen TM, De J Labuschagne C, van Schalkwyk A, Steffens FE, Gaedigk A, Cromarty AD, Alessandrini M, Pepper MS.
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Tafenoquine for travelers' malaria: evidence, rationale and recommendations.
Baird JK.
J Travel Med. 2018 Jan 1;25(1). doi: 10.1093/jtm/tay110.
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Tafenoquine: First Global Approval.
Frampton JE.
Drugs. 2018 Sep;78(14):1517-1523. doi: 10.1007/s40265-018-0979-2.
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Management ofPlasmodium vivax risk and illness in travelers.
Baird JK.
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Implications of current therapeutic restrictions for primaquine and tafenoquine in the radical cure of vivax malaria.
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Tafenoquine plus chloroquine for the treatment and relapse prevention of Plasmodium vivax malaria (DETECTIVE): a multicentre, double-blind, randomised, phase 2b dose-selection study.
Llanos-Cuentas A, Lacerda MV, Rueangweerayut R, Krudsood S, Gupta SK, Kochar SK, Arthur P, Chuenchom N, Möhrle JJ, Duparc S, Ugwuegbulam C, Kleim JP, Carter N, Green JA, Kellam L.
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Tafenoquine and its potential in the treatment and relapse prevention of Plasmodium vivax malaria: the evidence to date.
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Randomized trial of 3-dose regimens of tafenoquine (WR238605) versus low-dose primaquine for preventing Plasmodium vivax malaria relapse.
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Tafenoquine and primaquine do not exhibit clinical neurologic signs associated with central nervous system lesions in the same manner as earlier 8-aminoquinolines.
Berman J, Brown T, Dow G, Toovey S.
Malar J. 2018 Nov 6;17(1):407. doi: 10.1186/s12936-018-2555-3. Review.
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A randomized, double-blind, active-control trial to evaluate the efficacy and safety of a three day course of tafenoquine monotherapy for the treatment of Plasmodium vivax malaria.
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The efficacy and tolerability of three different regimens of tafenoquine versus primaquine for post-exposure prophylaxis of Plasmodium vivax malaria in the Southwest Pacific.
Elmes NJ , Nasveld PE , Kitchener SJ, Kocisko DA, Edstein MD.
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[Role of primaquine in malaria control and elimination in French-speaking Africa].
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Malaria surveillance--United States, 1999.
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