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Updated research studies on malaria elimination in the world and Vietnam within the last 10 years
Diagnostic capacity, and predictive values of rapid diagnostic tests for accurate diagnosis of Plasmodium falciparum in febrile children in Asante-Akim, Ghana This study seeks to compare the performance of HRP2 (First Response) and pLDH/HRP2 (Combo) RDTs for falciparum malaria against microscopy and PCR in acutely ill febrile children at presentation and follow-up. Authors: Isabella A. Quakyi, George O. Adjei, David J. Sullivan Jr., Amos Laar, Judith K. Stephens, Richmond Owusu, Peter Winch, Kwame S. Sakyi, Nathaniel Coleman, Francis D. Krampa, Edward Essuman, Vivian N. A. Aubyn, Isaac A. Boateng, Bernard B. Borteih, Linda Vanotoo, Juliet Tuakli? Citation: Malaria Journal 2018 17:468 Published on: 14 December 2018 Mitochondrial gene sequence variants in children with severe malaria anaemia with or without lactic acidosis: a case control study Evolutionary pressure by Plasmodium falciparum malaria is known to have favoured a large number of human gene adaptations, but there is surprisingly little investigation of the effect of malaria on human mitochon... Authors: Casey Fowler, Christine Cserti-Gazdewich, Aggrey Dhabangi, Charles Musoke, Himanshu Sharma, Sami S. Amr and Walter Dzik Citation: Malaria Journal 2018 17:467 Published on: 13 December 2018 Identification of a PH domain-containing protein which is localized to crystalloid bodies of Plasmodium ookinetes For the success of the malaria control and eradication programme it is essential to reduce parasite transmission by mosquito vectors. In the midguts of mosquitoes fed with parasite-infected blood, sexual-stage... Authors: Rachaneeporn Jenwithisuk, Niwat Kangwanrangsan, Mayumi Tachibana, Amporn Thongkukiatkul, Hitoshi Otsuki, Jetsumon Sattabongkot, Takafumi Tsuboi, Motomi Torii and Tomoko Ishino Citation: Malaria Journal 2018 17:466 Published on: 13 December 2018 The Plasmodium falciparum cytoplasmic translation apparatus: a promising therapeutic target not yet exploited by clinically approved anti-malarials The continued spectre of resistance to existing anti-malarials necessitates the pursuit of novel targets and mechanisms of action for drug development. one class of promising targets consists of the 80S riboso... Authors: Christine Moore Sheridan, Valentina E. Garcia, Vida Ahyong and Joseph L. DeRisi Citation: Malaria Journal 2018 17:465 Published on: 12 December 2018 Malaria causes long-term effects on markers of iron status in children: a critical assessment of existing clinical and epidemiological tools Most epidemiological studies on the interplay between iron deficiency and malaria risk classify individuals as iron-deficient or iron-replete based on inflammation-dependent iron markers and adjustment for inf... Authors: Filip C. Castberg, Edem W. Sarbah, Kwadwo A. Koram, Nicholas Opoku, Michael F. Ofori, Bjarne Styrishave, Lars Hviid and Jørgen A. L. Kurtzhals Citation: Malaria Journal 2018 17:464 Published on: 11 December 2018 Plasmodium falciparum artemisinin resistance monitoring in Sabah, Malaysia: in vivo therapeutic efficacy and kelch13 molecular marker surveillance Spreading Plasmodium falciparum artemisinin drug resistance threatens global malaria public health gains. Limited data exist to define the extent of P. falciparum artemisinin resistance southeast of the Greater M... Authors: Matthew J. Grigg, Timothy William, Kim A. Piera, Giri S. Rajahram, Jenarun Jelip, Ammar Aziz, Jayaram Menon, Jutta Marfurt, Ric N. Price, Sarah Auburn, Bridget E. Barber, Tsin W. Yeo and Nicholas M. Anstey Citation: Malaria Journal 2018 17:463 Published on: 10 December 2018 A discovery and development roadmap for new endectocidal transmission-blocking agents in malaria Reaching the overall goal of eliminating malaria requires halting disease transmission. one approach to blocking transmission is to prevent passage of the parasite to a mosquito, by preventing formation or tra... Authors: Jeremy Burrows, Hannah Slater, Fiona Macintyre, Sarah Rees, Anna Thomas, Fredros Okumu, Rob Hooft van Huijsduijnen, Stephan Duparc and Timothy N. C. Wells Citation: Malaria Journal 2018 17:462 Published on: 10 December 2018 Evaluating the quality of routinely reported data on malaria commodity stocks in Guinea, 2014?2016 Ensuring malaria commodity availability at health facilities is a cornerstone of malaria control. Since 2013, the Guinea National Malaria Control Programme has been routinely collecting data on stock levels of... Authors: Yu Sun, Timothée Guilavogui, Alioune Camara, Mohamed Dioubaté, Babacar Deen Toure, Claude Bahati, Marie Paule Fargier, Jessica Butts, Patrick Condo, Abdoulaye Sarr and Mateusz M. Plucinski Citation: Malaria Journal 2018 17:461 Published on: 7 December 2018 Spatial distribution and determinants of asymptomatic malaria risk among children under 5 years in 24 districts in Burkina Faso In malaria endemic countries, asymptomatic cases constitute an important reservoir of infections sustaining transmission. Estimating the burden of the asymptomatic population and identifying areas with elevate... Authors: Mady Ouédraogo, Sékou Samadoulougou, Toussaint Rouamba, Hervé Hien, John E. M. Sawadogo, Halidou Tinto, Victor A. Alegana, Niko Speybroeck and Fati Kirakoya-Samadoulougou Citation: Malaria Journal 2018 17:460 Published on: 7 December 2018 ?To be honest, women do everything?: understanding roles of men and women in net care and repair in Southern Tanzania In Tanzania, the roles of men and women are classified based on the local cultural context. While men are usually the breadwinners, women are traditionally responsible for most domestic chores. Particularly fo... Authors: Angel Dillip, Zawadi Mageni Mboma, George Greer and Lena M. Lorenz Citation: Malaria Journal 2018 17:459 Published on: 7 December 2018 Genetic diversity and allele frequencies of Plasmodium falciparum msp1 and msp2 in parasite isolates from Bioko Island, Equatorial Guinea Malaria is still a serious public health problem on Bioko Island (Equatorial Guinea), although the number of annual cases has been greatly reduced since 2004 through the Bioko Island Malaria Control Project (B... Authors: Jiang-Tao Chen, Jian Li, Guang-Cai Zha, Guang Huang, Zhi-Xiu Huang, Dong-De Xie, Xia Zhou, Huan-Tong Mo, Juan Urbano Monsuy Eyi, Rocio Apicante Matesa, Maximo Miko ondo Obono, Shan Li, Xiang-Zhi Liu and Min Lin Citation: Malaria Journal 2018 17:458 Published on: 7 December 2018 Cryogenically preserved RBCs support gametocytogenesis of Plasmodium falciparum in vitro and gametogenesis in mosquitoes The malaria Eradication Research Agenda (malERA) has identified human-to-mosquito transmission of Plasmodium falciparum as a major target for eradication. The cornerstone for identifying and evaluating transmissi... Authors: Ashutosh K. Pathak, Justine C. Shiau, Matthew B. Thomas and Courtney C. Murdock Citation: Malaria Journal 2018 17:457 Published on: 6 December 2018 Interplay between Plasmodium falciparum haemozoin and l-arginine: implication for nitric oxide production Plasmodium falciparum haemozoin, a detoxification product of digested haemoglobin from infected erythrocytes, is released into the bloodstream upon schizont rupture and accumulates in leukocytes. High levels of h... Authors: Yolanda Corbett, Sarah D?Alessandro, Silvia Parapini, Diletta Scaccabarozzi, Parisa Kalantari, Stefania Zava, Flavio Giavarini, Donatella Caruso, Irma Colombo, Timothy J. Egan and Nicoletta Basilico Citation: Malaria Journal 2018 17:456 Published on: 6 December 2018 Exploring the gap between coverage, access, and utilization of long-lasting insecticide-treated nets (LLINs) among the households of malaria endemic districts in Bangladesh Malaria is still a major public health concern in Bangladesh in spite of mass distribution of long-lasting insecticide-treated nets (LLINs) as a key preventive strategy. There might be a considerable gap betwe... Authors: Fouzia Khanam, Md Belal Hossain, Tridib Roy Chowdhury, Md Sajedur Rahman, Moktadir Kabir, Shamsun Naher, Md Akramul Islam and Mahfuzar Rahman Citation: Malaria Journal 2018 17:455 Published on: 6 December 2018 Reshaping the vector control strategy for malaria elimination in Ethiopia in the context of current evidence and new tools: opportunities and challenges The core vector control measures, long-lasting insecticidal nets (LLINs) and indoor residual spraying (IRS), reduce the risk of malaria infection by targeting indoor biting mosquitoes. These two interventions ... Authors: Taye Gari and Bernt Lindtjørn Citation: Malaria Journal 2018 17:454 Published on: 5 December 2018 Using mixed effects logistic regression models for complex survey data on malaria rapid diagnostic test results The effect of malaria in Nigeria is still worrisome and has remained a leading public health issue in the country. In 2016, Nigeria was the highest malaria burden country among the 15 countries in sub-Saharan ... Authors: Chigozie Louisa J. Ugwu and Temesgen T. Zewotir Citation: Malaria Journal 2018 17:453 Published on: 5 December 2018 Nationwide school malaria parasitaemia survey in public primary schools, the United Republic of Tanzania A nationwide, school, malaria survey was implemented to assess the risk factors of malaria prevalence and bed net use among primary school children in mainland Tanzania. This allowed the mapping of malaria pre... Authors: Frank Chacky, Manuela Runge, Susan F. Rumisha, Pendael Machafuko, Prosper Chaki, Julius J. Massaga, Ally Mohamed, Emilie Pothin, Fabrizio Molteni, Robert W. Snow, Christian Lengeler and Renata Mandike Citation: Malaria Journal 2018 17:452 Published on: 5 December 2018 Treatments used for malaria in young Ethiopian children: a retrospective study In Ethiopia, medicinal plants have been used to treat different diseases, including malaria, for many centuries. People living in rural areas are especially noted for their use of medicinal plants as a major c... Authors: Abyot Endale Gurmu, Teresa Kisi, Habteweld Shibru, Bertrand Graz and Merlin Willcox Citation: Malaria Journal 2018 17:451 Published on: 5 December 2018 Accuracy of one Step malaria rapid diagnostic test (RDT) in detecting Plasmodium falciparum placental malaria infection in women living in Yaoundé, Cameroon Plasmodium falciparum infected erythrocytes sequestering in placental tissue release Plasmodium lactate dehydrogenase (pLDH) and histidine-rich protein-II (HRP-II). These proteins can be detected in peripheral bl... Authors: Rosette Megnekou, Jean Claude Djontu, Benderli C. Nana, Jude D. Bigoga, Maurice Fotso, Balotin Fogang and Rose F. G. Leke Citation: Malaria Journal 2018 17:450 Published on: 4 December 2018 Malaria case investigation with reactive focal testing and treatment: operational feasibility and lessons learned from low and moderate transmission areas in Amhara Region, Ethiopia When malaria transmission is very low, investigation of passively detected malaria cases and reactive focal testing and treatment (FTAT) in the case and neighbouring households can identify and contain the sou... Authors: Pooja Bansil, Asnakew K. Yeshiwondim, Caterina Guinovart, Belendia Serda, Callie Scott, Berhane H. Tesfay, Adem Agmas, Belay Bezabih, Melkamu T. Zeleke, Girma S. Guesses, Asmamaw L. Ayenew, Worku M. Workie, Duncan Earle, Rick W. Steketee and Asefaw Getachew Citation: Malaria Journal 2018 17:449 Published on: 4 December 2018 Spontaneous splenic rupture in Plasmodium knowlesi malaria Plasmodium knowlesi, a malaria parasite typically found in long-tailed and pig-tailed macaques, is the most common cause of human malaria in Malaysian Borneo. Infections in humans result in a spectrum of disease,... Authors: Chee Yik Chang, Wei Chieng Pui, Khamisah Abdul Kadir and Balbir Singh Citation: Malaria Journal 2018 17:448 Published on: 4 December 2018 Diversity analysis of MSP1 identifies conserved epitope organization in block 2 amidst high sequence variability in Indian Plasmodium falciparum isolates Despite its immunogenicity, the polymorphic nature of merozoite surface protein 1, an important vaccine candidate for Plasmodium falciparum malaria, remains a concern. This study analyses the impact of genetic va... Authors: Sharmistha Ghoshal, Pragya Gajendra, Sumana Datta Kanjilal, Mitashree Mitra and Sanghamitra Sengupta Citation: Malaria Journal 2018 17:447 Published on: 3 December 2018 Comparing the un-comparable: Olyset Plus and Olyset, different malaria impact In a recent article in The Lancet, Protopopoff et al. stated that insecticide resistance must be tackled and concluded that adding the insecticide synergist piperonyl butoxide (PBO) to a bed net with a pyrethroid... Authors: Ole Skovmand Citation: Malaria Journal 2018 17:446 Published on: 30 November 2018 Dry season occurrence of Anopheles mosquitoes and implications in Jabi Tehnan District, West Gojjam Zone, Ethiopia Generating evidence on the dry season occurrence of the larval and adult stages of Anopheles mosquitoes helps to design effective malaria vector control strategy as the populations of the vectors is expected to b... Authors: Abebe Animut and Yohannes Negash Citation: Malaria Journal 2018 17:445 Published on: 29 November 2018 A new approach to gathering pharmaceutical market data to support policy implementation and access to medicines: as demonstrated by malaria medicines in Zambia The steady supply of quality, affordable medicines is a pillar of a functioning health system. In addition to the public sector, the private, mission and not-for-profit sectors often serve a large part of the ... Authors: Renia Coghlan, Peter Stephens, Bernice Mwale and Makomani Siyanga Citation: Malaria Journal 2018 17:444 Published on: 29 November 2018 Area of exposure and treatment challenges of malaria in Eritrean migrants: a GeoSentinel analysis Recent reports highlight malaria as a frequent diagnosis in migrants who originate from Eritrea. A descriptive analysis of GeoSentinel cases of malaria in Eritrean migrants was done together with a literature ... Authors: Patricia Schlagenhauf, Martin P. Grobusch, Davidson H. Hamer, Hilmir Asgeirsson, Mogens Jensenius, Gilles Eperon, Camilla Rothe, Egon Isenring, Jan Fehr, Eli Schwartz, Emmanuel Bottieau, Elizabeth D. Barnett, Anne McCarthy, Paul Kelly, Carsten Schade Larsen, Perry van Genderen? Citation: Malaria Journal 2018 17:443 Published on: 29 November 2018 Within-population genetic diversity and population structure of Plasmodium knowlesi merozoite surface protein 1 gene from geographically distinct regions of Malaysia and Thailand The C-terminal 42 kDa domain of Plasmodium knowlesi merozoite surface protein 1 (PkMSP1) is a potential asexual blood-stage vaccine candidate, however, only a limited number of clinical isolates have been analyse... Authors: Md Atique Ahmed, Ki-Back Chu, Indra Vythilingam and Fu-Shi Quan Citation: Malaria Journal 2018 17:442 Published on: 29 November 2018 A multiplex assay for the sensitive detection and quantification of male and female Plasmodium falciparum gametocytes The transmission of malaria to mosquitoes depends on the presence of gametocytes that circulate in the peripheral blood of infected human hosts. Sensitive estimates of the densities of female gametocytes (FG) ... Authors: Lisette Meerstein-Kessel, Chiara Andolina, Elvira Carrio, Almahamoudou Mahamar, Patrick Sawa, Halimatou Diawara, Marga van de Vegte-Bolmer, Will Stone, Katharine A. Collins, Petra Schneider, Alassane Dicko, Chris Drakeley, Ingrid Felger, Till Voss, Kjerstin Lanke and Teun Bousema Citation: Malaria Journal 2018 17:441 Published on: 29 November 2018 Challenges for the diagnosis and treatment of malaria in low transmission settings in San Lorenzo, Esmeraldas, Ecuador Ecuador is on the verge of eliminating malaria according to the World Health Organization criteria. Nevertheless, active transmission foci still persist in the country, and these represent an important challen... Authors: Mayte Mosquera-Romero, Lina Zuluaga-Idárraga and Alberto Tobón-Castaño Citation: Malaria Journal 2018 17:440 Published on: 28 November 2018 Molecular identification of Plasmodium species responsible for malaria reveals Plasmodium vivax isolates in Duffy negative individuals from southwestern Nigeria Malaria in Nigeria is principally due to Plasmodium falciparum and, to a lesser extent to Plasmodium malariae and Plasmodium ovale. Plasmodium vivax is thought to be absent in Nigeria in particular and sub-Sahara... Authors: Mary Aigbiremo Oboh, Aida Sadikh Badiane, Godwin Ntadom, Yaye Die Ndiaye, Khadim Diongue, Mamadou Alpha Diallo and Daouda Ndiaye Citation: Malaria Journal 2018 17:439 Published on: 28 November 2018 Outreach training and supportive supervision for malaria case management in Zambia: the effects of focused capacity building on indicators of diagnostic and clinical performance Accurate diagnosis of malaria and reduced reliance on presumptive treatment are crucial components of quality case management. From 2008 to 2012, the Improving Malaria Diagnostics project, in collaboration wit... Authors: Matt Worges, Nicole Whitehurst, Emanuel Yamo, Hawela Moonga, Joshua Yukich and Luis Benavente Citation: Malaria Journal 2018 17:438 Published on: 28 November 2018 Controlled release spatial repellent devices (CRDs) as novel tools against malaria transmission: a semi-field study in Macha, Zambia The emergence of mosquitoes that can avoid indoor-deployed interventions, such as treated bed nets and indoor residual spraying, threatens the mainstay of malaria control in Zambia. Furthermore, the requiremen... Authors: Jennifer C. Stevenson, Limonty Simubali, Twig Mudenda, Esther Cardol, Ulrich R. Bernier, Agustin Abad Vazquez, Philip E. Thuma, Douglas E. Norris, Melynda Perry, Daniel L. Kline, Lee W. Cohnstaedt, Pablo Gurman, Sebastian D?hers and Noel M. Elman Citation: Malaria Journal 2018 17:437 Published on: 26 November 2018 Aspidosperma pyrifolium, a medicinal plant from the Brazilian caatinga, displays a high antiplasmodial activity and low cytotoxicity Several species of Aspidosperma plants are referred to as remedies for the treatment of malaria, especially Aspidosperma nitidum. Aspidosperma pyrifolium, also a medicinal plant, is used as a natural anti-inflamm... Authors: Isabela P. Ceravolo, Carlos L. Zani, Flávio J. B. Figueiredo, Markus Kohlhoff, Antônio E. G. Santana and Antoniana U. Krettli Citation: Malaria Journal 2018 17:436 Published on: 26 November 2018 Brain swelling is independent of peripheral plasma cytokine levels in Malawian children with cerebral malaria Cerebral malaria (CM) is often fatal, and severe brain swelling is a predictor of CM-related mortality. CM is characterized by elevated circulating pro-inflammatory cytokines TNF and IFN-? and anti-inflammator... Authors: Visopo Harawa, Madi Njie, Anne Kessler, Augustine Choko, Benjamin Kumwenda, Sam Kampondeni, Michael Potchen, Kami Kim, Anthony Jaworowski, Terrie Taylor, Wilson Mandala, Karl Seydel and Stephen Rogerson Citation: Malaria Journal 2018 17:435 Published on: 26 November 2018 Lack of significant recovery of chloroquine sensitivity in Plasmodium falciparum parasites following discontinuance of chloroquine use in Papua New Guinea Chloroquine treatment for Plasmodium falciparum has been discontinued in almost all endemic regions due to the spread of resistant isolates. Reversal of chloroquine susceptibility after chloroquine discontinuatio... Authors: Makoto Sekihara, Shin-Ichiro Tachibana, Masato Yamauchi, Shoki Yatsushiro, Steven Tiwara, Naoyuki Fukuda, Mie Ikeda, Toshiyuki Mori, Makoto Hirai, Francis Hombhanje and Toshihiro Mita Citation: Malaria Journal 2018 17:434 Published on: 26 November 2018 Roll Back Malaria: an historical footnote Prompted by the 20th anniversary of Roll Back Malaria, the author recalls hypotheses concerning a major new initiative to control malaria in Africa put forward by WHO AFRO and the World Bank in 1996. These hyp... Authors: Sir Richard Feachem Citation: Malaria Journal 2018 17:433 Published on: 19 November 2018 Cross-sectional study on the adherence to malaria guidelines in lakeshore facilities of Buyende and Kaliro districts, Uganda Uganda adopted the Integrated Management of Malaria (IMM) guidelines, which require testing all suspected cases of malaria prior to treatment and which have been implemented throughout the country. However, ad... Authors: Henry Kaula, Sylvia Kiconco and Luigi Nuñez Citation: Malaria Journal 2018 17:432 Published on: 19 November 2018 Correction to: Mapping a Plasmodium transmission spatial suitability index in Solomon Islands: a malaria monitoring and control tool Following publication of the original article [1], one of the authors flagged that the images for Figs. 2 and 3 were swapped in the published article?Fig. 2 had the image meant for Fig. 3 and vice versa. Authors: Isabelle Jeanne, Lynda E. Chambers, Adna Kazazic, Tanya L. Russell, Albino Bobogare, Hugo Bugoro, Francis Otto, George Fafale and Amanda Amjadali Citation: Malaria Journal 2018 17:431 Published on: 19 November 2018 The original article was published in Malaria Journal 2018 17:381 Inter-sectoral approaches for the prevention and control of malaria among the mobile and migrant populations: a scoping review Malaria cases among mobile and migrant populations (MMPs) represent a large and important reservoir for transmission, if undetected or untreated. The objectives of this review were to identify which intersecto... Authors: Cho Naing, Maxine A. Whittaker and Marcel Tanner Citation: Malaria Journal 2018 17:430 Published on: 16 November 2018 Severe Plasmodium vivax malaria, HIV, tuberculosis co-infection in a Sri Lankan traveller: case management and challenges during the prevention of malaria reintroduction phase The country received malaria-free certification from WHO in September 2016, becoming only the second country in the WHO South East Asia region to be declared malaria-free. Imported malaria cases continue to be... Authors: Dewanee Ranaweera, R. M. J. Kanchana Rajapaksha, Priyanganie Silva, Raja Hettiarachchi, W. M. Kumudu T. de A. W. Gunasekera, Hemantha Herath and Deepika Fernando Citation: Malaria Journal 2018 17:429 Published on: 16 November 2018 Bayesian spatiotemporal analysis of malaria infection along an international border: Hlaingbwe Township in Myanmar and Tha-Song-Yang District in Thailand One challenge in moving towards malaria elimination is cross-border malaria infection. The implemented measures to prevent and control malaria re-introduction across the demarcation line between two countries ... Authors: Aung Minn Thway, Chawarat Rotejanaprasert, Jetsumon Sattabongkot, Siam Lawawirojwong, Aung Thi, Tin Maung Hlaing, Thiha Myint Soe and Jaranit Kaewkungwal Citation: Malaria Journal 2018 17:428 Published on: 16 November 2018 Real time PCR detection of common CYP2D6 genetic variants and its application in a Karen population study Plasmodium vivax malaria is characterized by relapses arising from the hypnozoite stages in the liver. The only currently registered drug for radical treatment to prevent relapse is primaquine. Primaquine, a prod... Authors: Kanokpich Puaprasert, Cindy Chu, Naowarat Saralamba, Nicholas P. J. Day, Francois Nosten, Nicholas J. White, Arjen M. Dondorp and Mallika Imwong Citation: Malaria Journal 2018 17:427 Published on: 15 November 2018 Levels of human proteins in plasma associated with acute paediatric malaria The intimate interaction between the pathophysiology of the human host and the biology of the Plasmodium falciparum parasite results in a wide spectrum of disease outcomes in malaria. Development of severe diseas... Authors: Philippa Reuterswärd, Sofia Bergström, Judy Orikiiriza, Elisabeth Lindquist, Sven Bergström, Helene Andersson Svahn, Burcu Ayoglu, Mathias Uhlén, Mats Wahlgren, Johan Normark, Ulf Ribacke and Peter Nilsson Citation: Malaria Journal 2018 17:426 Published on: 15 November 2018 Fear and rumours regarding placental biopsies in a malaria-in-pregnancy trial in Benin A multi-country, community-based trial on scheduled screening and treatment for malaria in pregnancy was conducted in Benin, The Gambia and Burkina Faso. Despite standardized procedures and outcomes, the study... Authors: Adélaïde Compaoré, Susan Dierickx, Fatou Jaiteh, Alain Nahum, Towanou Francis Emmanuel Bohissou, Halidou Tinto, Susana Scott, Umberto D?Alessandro, Henk Schallig and Koen Peeters Grietens Citation: Malaria Journal 2018 17:425 Published on: 15 November 2018 Impact evaluation of malaria control interventions on morbidity and all-cause child mortality in Mali, 2000?2012 Major investments have been made since 2001, with intensification of malaria control interventions after 2006. Interventions included free distribution of insecticide-treated nets (ITN) to pregnant women and chil... Authors: Kassoum Kayentao, Lia S. Florey, Jules Mihigo, Abdoul Doumbia, Aliou Diallo, Diakalia Koné, Ogobara Doumbo and Erin Eckert Citation: Malaria Journal 2018 17:424 Published on: 14 November 2018 Age and gender trends in insecticide-treated net use in sub-Saharan Africa: a multi-country analysis The degree to which insecticide-treated net (ITN) supply accounts for age and gender disparities in ITN use among household members is unknown. This study explores the role of household ITN supply in the varia... Authors: Bolanle Olapeju, Ifta Choiriyyah, Matthew Lynch, Angela Acosta, Sean Blaufuss, Eric Filemyr, Hunter Harig, April Monroe, Richmond Ato Selby, Albert Kilian and Hannah Koenker Citation: Malaria Journal 2018 17:423 Published on: 14 November 2018 ResistanceSim: development and acceptability study of a serious game to improve understanding of insecticide resistance management in vector control programmes The use of insecticides is the cornerstone of effective malaria vector control. However, the last two decades has seen the ubiquitous use of insecticides, predominantly pyrethroids, causing widespread insectic... Authors: Edward K. Thomsen, Charlotte Hemingway, Andy South, Kirsten A. Duda, Claire Dormann, Robert Farmer, Michael Coleman and Marlize Coleman Citation: Malaria Journal 2018 17:422 Published on: 13 November 2018 LLIN Evaluation in Uganda Project (LLINEUP): factors associated with ownership and use of long-lasting insecticidal nets in Uganda: a cross-sectional survey of 48 districts Long-lasting insecticidal nets (LLINs) are a key malaria control intervention. To investigate factors associated with ownership and use of LLINs in Uganda, a cross-sectional community survey was conducted in M... Authors: Samuel Gonahasa, Catherine Maiteki-Sebuguzi, Sheila Rugnao, Grant Dorsey, Jimmy Opigo, Adoke Yeka, Agaba Katureebe, Mary Kyohere, Amy Lynd, Janet Hemingway, Martin Donnelly, Moses R. Kamya and Sarah G. Staedke Citation: Malaria Journal 2018 17:421 Published on: 13 November 2018 Correlation of malaria parasitaemia with peripheral blood monocyte to lymphocyte ratio as indicator of susceptibility to severe malaria in Ghanaian children Even though malaria is generally on the decline due extensive control and elimination efforts, it still remains a public health problem for over 40% of the world?s population. During the course of malaria infe... Authors: Samuel Antwi-Baffour, Ransford Kyeremeh, Dorcas Buabeng, Jonathan Kofi Adjei, Claudia Aryeh, George Kpentey and Mahmood Abdulai Seidu Citation: Malaria Journal 2018 17:419 Published on: 12 November 2018 Malaria epidemiology in Suriname from 2000 to 2016: trends, opportunities and challenges for elimination Suriname has experienced a significant change in malaria transmission risk and incidence over the past years. The country is now moving toward malaria elimination. The first objective of this study is to descr... Authors: Hélène Hiwat, Beatriz Martínez-López, Hedley Cairo, Loretta Hardjopawiro, Agatha Boerleider, Elisabeth Carmen Duarte and Zaida E. Yadon Citation: Malaria Journal 2018 17:418 Published on: 12 November 2018 The World Health Organization recommends the use of artemisinin-based combination therapy (ACT) to treat uncomplicated malaria for the control of malaria across the world. There are several types of ACT used a... Authors: Alioune Camara, Leah F. Moriarty, Timothée Guilavogui, Papa Sambou Diakité, Joseph Souba Zoumanigui, Sidikiba Sidibé, Ibrahima Bah, Ibrahima Kaba, Djebory Kourouma, Koho Zoumanigui and Mateusz Plucinski Citation: Malaria Journal 2019 18:23 Published on: 25 January 2019 Glucose 6-phosphate dehydrogenase 6-phosphogluconolactonase: characterization of the Plasmodium vivax enzyme and inhibitor studies Since malaria parasites highly depend on ribose 5-phosphate for DNA and RNA synthesis and on NADPH as a source of reducing equivalents, the pentose phosphate pathway (PPP) is considered an excellent anti-malar... Authors: Kristina Haeussler, Isabell Berneburg, Esther Jortzik, Julia Hahn, Mahsa Rahbari, Norma Schulz, Janina Preuss, Viktor A. Zapol?skii, Lars Bode, Anthony B. Pinkerton, Dieter E. Kaufmann, Stefan Rahlfs and Katja Becker Citation: Malaria Journal 2019 18:22 Published on: 25 January 2019 Collaborative intelligence and gamification for on-line malaria species differentiation Current World Health Organization recommendations for the management of malaria include the need for a parasitological confirmation prior to triggering appropriate treatment. The use of rapid diagnostic tests ... Authors: María Linares, María Postigo, Daniel Cuadrado, Alejandra Ortiz-Ruiz, Sara Gil-Casanova, Alexander Vladimirov, Jaime García-Villena, José María Nuñez-Escobedo, Joaquín Martínez-López, José Miguel Rubio, María Jesús Ledesma-Carbayo, Andrés Santos, Quique Bassat and Miguel Luengo-Oroz Citation: Malaria Journal 2019 18:21 Published on: 24 January 2019 Molecular characterization and mapping of glucose-6-phosphate dehydrogenase (G6PD) mutations in the Greater Mekong Subregion Plasmodium vivax malaria elimination can only be achieved by the deployment of 8-aminoquinolines (primaquine and tafenoquine) in combination with ACT to kill both blood and liver-stage parasites. However, primaqu... Authors: Germana Bancone, Didier Menard, Nimol Khim, Saorin Kim, Lydie Canier, Chea Nguong, Koukeo Phommasone, Mayfong Mayxay, Sabine Dittrich, Malavanh Vongsouvath, Nadine Fievet, Jean-Yves Le Hesran, Valerie Briand, Sommay Keomany, Paul N. Newton, Gornpan Gorsawun? Citation: Malaria Journal 2019 18:20 Published on: 23 January 2019 Interaction between maternally derived antibodies and heterogeneity in exposure combined to determine time-to-first Plasmodium falciparum infection in Kenyan infants Studies of the association between the level of anti-malarial antibody and protection from malaria infection can yield conflicting results if they fail to take into account differences in the malaria transmiss... Authors: Arnold Reynaldi, Arlene E. Dent, Timothy E. Schlub, Sidney Ogolla, Rosemary Rochford and Miles P. Davenport Citation: Malaria Journal 2019 18:19 Published on: 22 January 2019 Evaluation of Plasmodium vivax malaria recurrence in Brazil Control of vivax malaria in endemic areas requires management of recurrence. The Brazilian National Malaria Surveillance System (SIVEP-Malária) records every case of malaria in Brazil, but is not designed to d... Authors: André Daher, Júlio C. A. L. Silva, Antony Stevens, Paola Marchesini, C. J. Fontes, F. O. Ter Kuile and David G. Lalloo Citation: Malaria Journal 2019 18:18 Published on: 22 January 2019 Risk of transfusion-transmitted malaria: evaluation of commercial ELISA kits for the detection of anti-Plasmodium antibodies in candidate blood donors Transfusion with Plasmodium-infected blood represents a risk for malaria transmission, a rare but severe event. Several non-endemic countries implement a strategy for the screening of candidate blood donors inclu... Authors: Valentina D. Mangano, Francesca Perandin, Natalia Tiberti, Massimo Guerriero, Franca Migliaccio, Marco Prato, Lucia Bargagna, Stefano Tais, Monica Degani, Federica Verra, Zeno Bisoffi and Fabrizio Bruschi Citation: Malaria Journal 2019 18:17 Published on: 22 January 2019 Comparative analysis of IgG and IgG subclasses against Plasmodium falciparum MSP-119 in children from five contrasting bioecological zones of Cameroon Studies reporting the natural immune responses against malaria in children from different geographical settings in endemic areas are not readily available. This study was aimed at comparing the immune response... Authors: Tebit Emmanuel Kwenti, Tufon Anthony Kukwah, Tayong Dizzle Bita Kwenti, Babila Raymond Nyassa, Meriki Henry Dilonga, George Enow-Orock, Nicholas Tendongfor, Nota Damian Anong, Samuel Wanji, Longdoh Anna Njunda and Theresa Nkuo-Akenji Citation: Malaria Journal 2019 18:16 Published on: 22 January 2019 Evaluation of automated malaria diagnosis using the Sysmex XN-30 analyser in a clinical setting Early and accurate diagnosis of malaria is a critical aspect of efforts to control the disease, and several diagnostic tools are available. Microscopic assessment of a peripheral blood smear enables direct vis... Authors: Evashin Pillay, Shanaz Khodaiji, Belinda C. Bezuidenhout, Monwabisi Litshie and Thérèsa L. Coetzer Citation: Malaria Journal 2019 18:15 Published on: 22 January 2019 Bead-based assays to simultaneously detect multiple human inherited blood disorders associated with malaria Glucose-6-phosphate dehydrogenase deficiency (G6PDd), haemoglobin C (HbC) and S (HbS) are inherited blood disorders (IBD) common in populations in malaria endemic areas. All are associated to some degree with ... Authors: Lynn Grignard, Catherine Mair, Jonathan Curry, Laleta Mahey, Guide J. H. Bastiaens, Alfred B. Tiono, Joseph Okebe, Sam A. Coulibaly, Bronner P. Gonçalves, Muna Affara, Alphonse Ouédraogo, Edith C. Bougouma, Guillaume S. Sanou, Issa Nébié, Kjerstin H. W. Lanke, Sodiomon B. Sirima? Citation: Malaria Journal 2019 18:14 Published on: 21 January 2019 Immunoglobulin G subclass and antibody avidity responses in Malian children immunized with Plasmodium falciparum apical membrane antigen 1 vaccine candidate FMP2.1/AS02A A malaria vaccine based on Plasmodium falciparum apical membrane antigen 1 (AMA1) elicited strain specific efficacy in Malian children that waned in the second season after vaccination despite sustained AMA1 anti... Authors: Andrea A. Berry, Eric R. Gottlieb, Bourema Kouriba, Issa Diarra, Mahamadou A. Thera, Sheetij Dutta, Drissa Coulibaly, Amed Ouattara, Amadou Niangaly, Abdoulaye K. Kone, Karim Traore, Youssouf Tolo, Vladimir Mishcherkin, Lorraine Soisson, Carter L. Diggs, William C. Blackwelder? Citation: Malaria Journal 2019 18:13 Published on: 18 January 2019 An online mapping database of molecular markers of drug resistance in Plasmodium falciparum: the ACT Partner Drug Molecular Surveyor Prior to this project, only a handful of online visualizations existed for exploring the published literature on molecular markers of antimalarial drug resistance, and none specifically for the markers associa... Authors: Sabina Dahlström Otienoburu, Ignacio Suay, Steven Garcia, Nigel V. Thomas, Suttipat Srisutham, Anders Björkman and Georgina S. Humphreys Citation: Malaria Journal 2019 18:12 Published on: 18 January 2019 The impact of early life exposure to Plasmodium falciparum on the development of naturally acquired immunity to malaria in young Malawian children Antibodies targeting malaria blood-stage antigens are important targets of naturally acquired immunity, and may act as valuable biomarkers of malaria exposure. Authors: Priyanka Barua, James G. Beeson, Kenneth Maleta, Per Ashorn and Stephen J. Rogerson Citation: Malaria Journal 2019 18:11 Published on: 18 January 2019 Susceptibility of Plasmodium falciparum to artemisinins and Plasmodium vivax to chloroquine in Phuoc Chien Commune, Ninh Thuan Province, south-central Vietnam Reduced artemisinin susceptibility and artemisinin-based combination therapy (ACT)-resistance against Plasmodium falciparum and chloroquine (CQ)-resistant P. vivax malaria has been reported in Vietnam. Two therap... Authors: Nguyen Chinh Phong, Marina Chavchich, Huynh Hong Quang, Nguyen Ngoc San, Geoffrey W. Birrell, Ilin Chuang, Nicholas J. Martin, Nguyen Duc Manh and Michael D. Edstein Citation: Malaria Journal 2019 18:10 Published on: 17 January 2019 Molecular monitoring of the diversity of human pathogenic malaria species in blood donations on Bioko Island, Equatorial Guinea Malaria can be transmitted by blood transfusion from human to human and it is responsible for the majority of transfusion-transmitted infectious diseases worldwide. In sub-Saharan Africa, it had been estimated... Authors: Tobias Schindler, Tamy Robaina, Julian Sax, Jose Raso Bieri, Maximilian Mpina, Linda Gondwe, Ludmila Acuche, Guillermo Garcia, Carlos Cortes, Carl Maas and Claudia Daubenberger Citation: Malaria Journal 2019 18:9 Published on: 15 January 2019 Application of the automated haematology analyzer XN-30 for discovery and development of anti-malarial drugs The erythrocytic stage of Plasmodium falciparum parasites in humans is clinically important, as the parasites at this growth stage causes malarial symptoms. Most of the currently available anti-malarial drugs tar... Authors: Takahiro Tougan, Yuji Toya, Kinya Uchihashi and Toshihiro Horii Citation: Malaria Journal 2019 18:8 Published on: 14 January 2019 MiRNA-146a polymorphism increases the odds of malaria in pregnancy Plasmodium falciparum infection during pregnancy is a major cause of poor maternal health, adverse foetal outcome and infant mortality in sub-Saharan Africa. Genetic disposition is involved in susceptibility to m... Authors: Welmoed van Loon, Prabhanjan P. Gai, Lutz Hamann, George Bedu-Addo and Frank P. Mockenhaupt Citation: Malaria Journal 2019 18:7 Published on: 14 January 2019 Measuring and characterizing night time human behaviour as it relates to residual malaria transmission in sub-Saharan Africa: a review of the published literature Malaria cases and deaths decreased dramatically in recent years, largely due to effective vector control interventions. Persistence of transmission after good coverage has been achieved with high-quality vecto... Authors: April Monroe, Sarah Moore, Hannah Koenker, Matthew Lynch and Emily Ricotta Citation: Malaria Journal 2019 18:6 Published on: 11 January 2019 Development of an agent-based model to assess the impact of substandard and falsified anti-malarials: Uganda case study Global efforts to address the burden of malaria have stagnated in recent years with malaria cases beginning to rise. Substandard and falsified anti-malarial treatments contribute to this stagnation. Poor quali... Authors: Sachiko Ozawa, Daniel R. Evans, Colleen R. Higgins, Sarah K. Laing and Phyllis Awor Citation: Malaria Journal 2019 18:5 Published on: 9 January 2019 Malaria parasite clearance rate regression: an R software package for a Bayesian hierarchical regression model Emerging resistance to anti-malarial drugs has led malaria researchers to investigate what covariates (parasite and host factors) are associated with resistance. In this regard, investigation of how covariates... Authors: Saeed Sharifi-Malvajerdi, Feiyu Zhu, Colin B. Fogarty, Michael P. Fay, Rick M. Fairhurst, Jennifer A. Flegg, Kasia Stepniewska and Dylan S. Small Citation: Malaria Journal 2019 18:4 Published on: 5 January 2019 Measuring malaria diagnosis and treatment coverage in population-based surveys: a recall validation study in Mali among caregivers of febrile children under 5 years Nationally-representative household surveys are the standard approach to monitor access to and treatment with artemisinin-based combination therapy (ACT) among children under 5 years (U5), however these indica... Authors: Ruth A. Ashton, Bakary Doumbia, Diadier Diallo, Thomas Druetz, Lia Florey, Cameron Taylor, Fred Arnold, Jules Mihigo, Diakalia Koné, Seydou Fomba, Erin Eckert and Thomas P. Eisele Citation: Malaria Journal 2019 18:3 Published on: 3 January 2019 Is Saglin a mosquito salivary gland receptor for Plasmodium falciparum? Saglin, a 100 kDa protein composed of two 50 kDa homodimers, is present in the salivary glands of Anopheles gambiae and has been considered an essential receptor for sporozoites (SPZ) of Plasmodium berghei and Pl... Authors: David A. O?Brochta, Robert Alford, Robert Harrell, Channa Aluvihare, Abraham G. Eappen, Tao Li, Sumana Chakravarty, B. Kim Lee Sim, Stephen L. Hoffman and Peter F. Billingsley Citation: Malaria Journal 2019 18:2 Published on: 3 January 2019 A social network analysis on immigrants and refugees access to services in the malaria elimination context There has been significant progress in eliminating malaria in Iran. The aim of this study is to investigate the structure of inter-organizational collaboration networks in the field of unauthorized immigrants ... Authors: Ensiyeh Jamshidi, Hassan Eftekhar Ardebili, Reza Yousefi-Nooraie, Ahmad Raeisi, Hossein Malekafzali Ardakani, Roya Sadeghi, Ahmad Ali Hanafi-Bojd and Reza Majdzadeh Citation: Malaria Journal 2019 18:1 Published on: 3 January 2019 Small-scale field evaluation of the efficacy and residual effect of Fludora® Fusion (mixture of clothianidin and deltamethrin) against susceptible and resistant Anopheles gambiae populations from Benin, West Africa In recognition of the threat of insecticide resistance in vectors of malaria, the WHO Global Malaria Programme recommends the development of an appropriate and comprehensive response to insecticide resistance.... Authors: Fiacre R. Agossa, Gil G. Padonou, Arsene Jacques Y. H. Fassinou, Esdras M. Odjo, Osei K. Akuoko, Albert Salako, Zinsou C. Koukpo, Udoka C. Nwangwu, Bruno Akinro, Michel Sezonlin and Martin C. Akogbeto Citation: Malaria Journal 2018 17:484 Published on: 29 December 2018 Heterogeneous distribution of k13 mutations in Plasmodium falciparum in Laos The emergence and transnational spread of artemisinin resistance in Plasmodium falciparum in the Greater Mekong Sub-region (GMS) is a serious threat to malaria elimination in the region and could present a threat... Authors: Moritoshi Iwagami, Masami Nakatsu, Phonepadith Khattignavong, Pheovaly Soundala, Sengdeuane Keomalaphet, Lavy Lorpachan, Phonepadith Xangsayalath, Emilie Matsumoto-Takahashi, Virginie Pommelet, Bouasy Hongvanthong, Paul T. Brey and Shigeyuki Kano Citation: Malaria Journal 2018 17:483 Published on: 27 December 2018 In vitro antiplasmodial activity, pharmacokinetic profiles and interference in isoprenoid pathway of 2-aniline-3-hydroxy-1.4-naphthoquinone derivatives Plasmodium falciparum has shown multidrug resistance, leading to the necessity for the development of new drugs with novel targets, such as the synthesis of isoprenic precursors, which are excellent targets becau... Authors: Valeska S. de Sena Pereira, Flávio da Silva Emery, Lis Lobo, Fátima Nogueira, Jonas I. N. Oliveira, Umberto L. Fulco, Eudenilson L. Albuquerque, Alejandro M. Katzin and Valter F. de Andrade-Neto Citation: Malaria Journal 2018 17:482 Published on: 19 December 2018 The effect of mobile phone text message reminders on health workers? adherence to case management guidelines for malaria and other diseases in Malawi: lessons from qualitative data from a cluster-randomized trial Mobile health (mHealth), which uses technology such as mobile phones to improve patient health and health care delivery, is increasingly being tested as an intervention to promote health worker (HW) performanc... Authors: Blessings N. Kaunda-Khangamwa, Laura C. Steinhardt, Alexander K. Rowe, Austin Gumbo, Dubulao Moyo, Humphreys Nsona, Peter Troell, Dejan Zurovac and Don Mathanga Citation: Malaria Journal 2018 17:481 Published on: 19 December 2018 Subpatent malaria in a low transmission African setting: a cross-sectional study using rapid diagnostic testing (RDT) and loop-mediated isothermal amplification (LAMP) from Zambezi region, Namibia Subpatent malaria infections, or low-density infections below the detection threshold of microscopy or standard rapid diagnostic testing (RDT), can perpetuate persistent transmission and, therefore, may be a b... Authors: Patrick McCreesh, Davis Mumbengegwi, Kathryn Roberts, Munyaradzi Tambo, Jennifer Smith, Brooke Whittemore, Gerard Kelly, Caitlin Moe, Max Murphy, Mukosha Chisenga, Bryan Greenhouse, Henry Ntuku, Immo Kleinschmidt, Hugh Sturrock, Petrina Uusiku, Roland Gosling? Citation: Malaria Journal 2018 17:480 Published on: 19 December 2018 Using the human blood index to investigate host biting plasticity: a systematic review and meta-regression of the three major African malaria vectors The proportion of mosquito blood-meals that are of human origin, referred to as the ?human blood index? or HBI, is a key determinant of malaria transmission. Authors: James Orsborne, Luis Furuya-Kanamori, Claire L. Jeffries, Mojca Kristan, Abdul Rahim Mohammed, Yaw A. Afrane, Kathleen O?Reilly, Eduardo Massad, Chris Drakeley, Thomas Walker and Laith Yakob Citation: Malaria Journal 2018 17:479 Published on: 18 December 2018 Genetic association between the Pfk13 gene mutation and artemisinin resistance phenotype in Plasmodium falciparum isolates from Yunnan Province, China The problem of anti-malarial drug resistance is a long-term challenge faced by malaria control in Yunnan Province. Recently, the detection rates of chloroquine-resistant molecular markers (Plasmodium falciparum c... Authors: Ying Dong, Jian Wang, Aiming Sun, Yan Deng, Mengni Chen, Yanchun Xu and Jingpo Xue Citation: Malaria Journal 2018 17:478 Published on: 18 December 2018 Diagnostic performance of salivary urea nitrogen dipstick to detect and monitor acute kidney disease in patients with malaria Acute kidney injury (AKI) is a common complication of malaria. In low resource settings, a lack of diagnostic tools and delayed treatment of malaria associated AKI lead to significant morbidity and mortality. ... Authors: Viviane Calice-Silva, Euclides Sacomboio, Jochen G. Raimann, Rhys Evans, Cruz dos Santos Sebastião, Adelino Tchilanda Tchivango, Peter Kotanko, Nathan Levin and Roberto Pecoits-Filho Citation: Malaria Journal 2018 17:477 Published on: 18 December 2018 Caregiver responses and association with delayed care-seeking in children with uncomplicated and severe malaria Gaps remain in understanding the role of caregiver responses on time to seek appropriate care. The objective of this study was to describe caregiver responses to illness and the impact of these responses on ti... Authors: Arthur Mpimbaza, Anne Katahoire, Philip J. Rosenthal, Charles Karamagi and Grace Ndeezi Citation: Malaria Journal 2018 17:476 Published on: 18 December 2018 Origins and spread of novel genetic variants of sulfadoxine?pyrimethamine resistance in Plasmodium falciparum isolates in Indonesia While malaria incidence in Indonesia has decreased threefold in the last decade, more than 200,000 cases were reported in 2016. Different endemicity of Plasmodium falciparum malaria among several islands in Indon... Authors: Sukmawati Basuki, Fitriah, Petronella M. Risamasu, Kasmijati, Pancawati Ariami, Sugeng Riyanto, Ari Hidayat, Dewi Susilowati, Iskandar, Budi Armika, Budiono, Yoes P. Dachlan, Hiroji Kanbara and Haruki Uemura Citation: Malaria Journal 2018 17:475 Published on: 17 December 2018 Community facilitators and barriers to a successful implementation of mass drug administration and indoor residual spraying for malaria prevention in Uganda: a qualitative study There is growing interest to add mass drug administration (MDA) to the already existing malaria prevention strategies, such as indoor residual spraying (IRS). However, successful MDA and IRS requires high popu... Authors: Humphrey Wanzira, Susan Naiga, Ronald Mulebeke, Fred Bukenya, Mariam Nabukenya, Osborn Omoding, Dorothy Echodu and Adoke Yeka Citation: Malaria Journal 2018 17:474 Published on: 17 December 2018 Host genetic polymorphisms and serological response against malaria in a selected population in Sri Lanka Antibodies against the merozoite surface protein 1-19 (MSP1-19) and the apical membrane antigen 1 (AMA1) of the malaria parasite (Plasmodium vivax) are proven to be important in protection against clinical diseas... Authors: Rajika L. Dewasurendra, Anna Jeffreys, Sharmini A. Gunawardena, Naduviladath V. Chandrasekharan, Kirk Rockett, Dominic Kwiatkowski and Nadira D. Karunaweera Citation: Malaria Journal 2018 17:473 Published on: 17 December 2018 Characterization of Plasmodium falciparum structure in Nigeria with malaria SNPs barcode Plasmodium falciparum malaria remains a major health challenge in Nigeria despite the global decline of its incidence and mortality rates. Although significant progress has been made in preventing the transmissio... Authors: Bolajoko E. Bankole, Adeyemi T. Kayode, Iguosadolo O. Nosamiefan, Philomena Eromon, Mary L. Baniecki, Rachel F. Daniels, Elizabeth J. Hamilton, Katelyn Durfee, Bronwyn MacInnis, Henrietta Okafor, Akintunde Sowunmi, Sarah K. Volkman, Pardis Sabeti, Dyann Wirth, Christian T. Happi and onikepe A. Folarin Citation: Malaria Journal 2018 17:472 Published on: 17 December 2018 Prevalence of molecular markers of sulfadoxine?pyrimethamine and artemisinin resistance in Plasmodium falciparum from Pakistan In Pakistan, artesunate (AS) in combination with sulfadoxine?pyrimethamine (SP) is the recommended treatment for uncomplicated Plasmodium falciparum malaria. Monitoring molecular markers of anti-malarial drug res... Authors: Adnan Yaqoob, Aamer Ali Khattak, Muhammad Faisal Nadeem, Huma Fatima, Gillian Mbambo, Amed Ouattara, Matthew Adams, Nadia Zeeshan and Shannon Takala-Harrison Citation: Malaria Journal 2018 17:471 Published on: 17 December 2018 Challenging diagnosis of congenital malaria in non-endemic areas Congenital malaria is usually defined as the detection of asexual forms of Plasmodium spp. in a blood sample of a neonate during perinatal age if there is no possibility of postpartum infection by a mosquito bite... Authors: Lorenza Romani, Stefania Pane, Carlo Severini, Michela Menegon, Gianluca Foglietta, Stefania Bernardi, Hyppolite K. Tchidjou, Andrea onetti Muda, Paolo Palma and Lorenza Putignani Citation: Malaria Journal 2018 17:470 Published on: 14 December 2018 Has doxycycline, in combination with anti-malarial drugs, a role to play in intermittent preventive treatment of Plasmodium falciparum malaria infection in pregnant women in Africa? According to the World Health Organization (WHO), Plasmodium falciparum malaria during pregnancy is responsible for deleterious consequences for the mother and her child. The administration of intermittent preven... Authors: Tiphaine Gaillard, Manon Boxberger, Marylin Madamet and Bruno Pradines Citation: Malaria Journal 2018 17:469 Published on: 14 December 2018 ·Diagnostic capacity, and predictive values of rapid diagnostic tests for accurate diagnosis of Plasmodium falciparum in febrile children in Asante-Akim, Ghana This study seeks to compare the performance of HRP2 (First Response) and pLDH/HRP2 (Combo) RDTs for falciparum malaria against microscopy and PCR in acutely ill febrile children at presentation and follow-up. Authors: Isabella A. Quakyi, George O. Adjei, David J. Sullivan Jr., Amos Laar, Judith K. Stephens, Richmond Owusu, Peter Winch, Kwame S. Sakyi, Nathaniel Coleman, Francis D. Krampa, Edward Essuman, Vivian N. A. Aubyn, Isaac A. Boateng, Bernard B. Borteih, Linda Vanotoo, Juliet Tuakli? Citation: Malaria Journal 2018 17:468 Published on: 14 December 2018 Mitochondrial gene sequence variants in children with severe malaria anaemia with or without lactic acidosis: a case control study Evolutionary pressure by Plasmodium falciparum malaria is known to have favoured a large number of human gene adaptations, but there is surprisingly little investigation of the effect of malaria on human mitochon... Authors: Casey Fowler, Christine Cserti-Gazdewich, Aggrey Dhabangi, Charles Musoke, Himanshu Sharma, Sami S. Amr and Walter Dzik Citation: Malaria Journal 2018 17:467 Published on: 13 December 2018 Identification of a PH domain-containing protein which is localized to crystalloid bodies of Plasmodium ookinetes For the success of the malaria control and eradication programme it is essential to reduce parasite transmission by mosquito vectors. In the midguts of mosquitoes fed with parasite-infected blood, sexual-stage... Authors: Rachaneeporn Jenwithisuk, Niwat Kangwanrangsan, Mayumi Tachibana, Amporn Thongkukiatkul, Hitoshi Otsuki, Jetsumon Sattabongkot, Takafumi Tsuboi, Motomi Torii and Tomoko Ishino Citation: Malaria Journal 2018 17:466 Published on: 13 December 2018 The Plasmodium falciparum cytoplasmic translation apparatus: a promising therapeutic target not yet exploited by clinically approved anti-malarials The continued spectre of resistance to existing anti-malarials necessitates the pursuit of novel targets and mechanisms of action for drug development. one class of promising targets consists of the 80S riboso... Authors: Christine Moore Sheridan, Valentina E. Garcia, Vida Ahyong and Joseph L. DeRisi Citation: Malaria Journal 2018 17:465 Published on: 12 December 2018 Malaria causes long-term effects on markers of iron status in children: a critical assessment of existing clinical and epidemiological tools Most epidemiological studies on the interplay between iron deficiency and malaria risk classify individuals as iron-deficient or iron-replete based on inflammation-dependent iron markers and adjustment for inf... Authors: Filip C. Castberg, Edem W. Sarbah, Kwadwo A. Koram, Nicholas Opoku, Michael F. Ofori, Bjarne Styrishave, Lars Hviid and Jørgen A. L. Kurtzhals Citation: Malaria Journal 2018 17:464 Published on: 11 December 2018 Plasmodium falciparum artemisinin resistance monitoring in Sabah, Malaysia: in vivo therapeutic efficacy and kelch13 molecular marker surveillance Spreading Plasmodium falciparum artemisinin drug resistance threatens global malaria public health gains. Limited data exist to define the extent of P. falciparum artemisinin resistance southeast of the Greater M... Authors: Matthew J. Grigg, Timothy William, Kim A. Piera, Giri S. Rajahram, Jenarun Jelip, Ammar Aziz, Jayaram Menon, Jutta Marfurt, Ric N. Price, Sarah Auburn, Bridget E. Barber, Tsin W. Yeo and Nicholas M. Anstey Citation: Malaria Journal 2018 17:463 Published on: 10 December 2018 A discovery and development roadmap for new endectocidal transmission-blocking agents in malaria Reaching the overall goal of eliminating malaria requires halting disease transmission. one approach to blocking transmission is to prevent passage of the parasite to a mosquito, by preventing formation or tra... Authors: Jeremy Burrows, Hannah Slater, Fiona Macintyre, Sarah Rees, Anna Thomas, Fredros Okumu, Rob Hooft van Huijsduijnen, Stephan Duparc and Timothy N. C. Wells Citation: Malaria Journal 2018 17:462 Published on: 10 December 2018 Evaluating the quality of routinely reported data on malaria commodity stocks in Guinea, 2014?2016 Ensuring malaria commodity availability at health facilities is a cornerstone of malaria control. Since 2013, the Guinea National Malaria Control Programme has been routinely collecting data on stock levels of... Authors: Yu Sun, Timothée Guilavogui, Alioune Camara, Mohamed Dioubaté, Babacar Deen Toure, Claude Bahati, Marie Paule Fargier, Jessica Butts, Patrick Condo, Abdoulaye Sarr and Mateusz M. Plucinski Citation: Malaria Journal 2018 17:461 Published on: 7 December 2018 Spatial distribution and determinants of asymptomatic malaria risk among children under 5 years in 24 districts in Burkina Faso In malaria endemic countries, asymptomatic cases constitute an important reservoir of infections sustaining transmission. Estimating the burden of the asymptomatic population and identifying areas with elevate... Authors: Mady Ouédraogo, Sékou Samadoulougou, Toussaint Rouamba, Hervé Hien, John E. M. Sawadogo, Halidou Tinto, Victor A. Alegana, Niko Speybroeck and Fati Kirakoya-Samadoulougou Citation: Malaria Journal 2018 17:460 Published on: 7 December 2018 ?To be honest, women do everything?: understanding roles of men and women in net care and repair in Southern Tanzania In Tanzania, the roles of men and women are classified based on the local cultural context. While men are usually the breadwinners, women are traditionally responsible for most domestic chores. Particularly fo... Authors: Angel Dillip, Zawadi Mageni Mboma, George Greer and Lena M. Lorenz Citation: Malaria Journal 2018 17:459 Published on: 7 December 2018 Genetic diversity and allele frequencies of Plasmodium falciparum msp1 and msp2 in parasite isolates from Bioko Island, Equatorial Guinea Malaria is still a serious public health problem on Bioko Island (Equatorial Guinea), although the number of annual cases has been greatly reduced since 2004 through the Bioko Island Malaria Control Project (B... Authors: Jiang-Tao Chen, Jian Li, Guang-Cai Zha, Guang Huang, Zhi-Xiu Huang, Dong-De Xie, Xia Zhou, Huan-Tong Mo, Juan Urbano Monsuy Eyi, Rocio Apicante Matesa, Maximo Miko ondo Obono, Shan Li, Xiang-Zhi Liu and Min Lin Citation: Malaria Journal 2018 17:458 Published on: 7 December 2018 Cryogenically preserved RBCs support gametocytogenesis of Plasmodium falciparum in vitro and gametogenesis in mosquitoes The malaria Eradication Research Agenda (malERA) has identified human-to-mosquito transmission of Plasmodium falciparum as a major target for eradication. The cornerstone for identifying and evaluating transmissi... Authors: Ashutosh K. Pathak, Justine C. Shiau, Matthew B. Thomas and Courtney C. Murdock Citation: Malaria Journal 2018 17:457 Published on: 6 December 2018 Interplay between Plasmodium falciparum haemozoin and l-arginine: implication for nitric oxide production Plasmodium falciparum haemozoin, a detoxification product of digested haemoglobin from infected erythrocytes, is released into the bloodstream upon schizont rupture and accumulates in leukocytes. High levels of h... Authors: Yolanda Corbett, Sarah D?Alessandro, Silvia Parapini, Diletta Scaccabarozzi, Parisa Kalantari, Stefania Zava, Flavio Giavarini, Donatella Caruso, Irma Colombo, Timothy J. Egan and Nicoletta Basilico Citation: Malaria Journal 2018 17:456 Published on: 6 December 2018 Exploring the gap between coverage, access, and utilization of long-lasting insecticide-treated nets (LLINs) among the households of malaria endemic districts in Bangladesh Malaria is still a major public health concern in Bangladesh in spite of mass distribution of long-lasting insecticide-treated nets (LLINs) as a key preventive strategy. There might be a considerable gap betwe... Authors: Fouzia Khanam, Md Belal Hossain, Tridib Roy Chowdhury, Md Sajedur Rahman, Moktadir Kabir, Shamsun Naher, Md Akramul Islam and Mahfuzar Rahman Citation: Malaria Journal 2018 17:455 Published on: 6 December 2018 Reshaping the vector control strategy for malaria elimination in Ethiopia in the context of current evidence and new tools: opportunities and challenges The core vector control measures, long-lasting insecticidal nets (LLINs) and indoor residual spraying (IRS), reduce the risk of malaria infection by targeting indoor biting mosquitoes. These two interventions ... Authors: Taye Gari and Bernt Lindtjørn Citation: Malaria Journal 2018 17:454 Published on: 5 December 2018 Using mixed effects logistic regression models for complex survey data on malaria rapid diagnostic test results The effect of malaria in Nigeria is still worrisome and has remained a leading public health issue in the country. In 2016, Nigeria was the highest malaria burden country among the 15 countries in sub-Saharan ... Authors: Chigozie Louisa J. Ugwu and Temesgen T. Zewotir Citation: Malaria Journal 2018 17:453 Published on: 5 December 2018 Nationwide school malaria parasitaemia survey in public primary schools, the United Republic of Tanzania A nationwide, school, malaria survey was implemented to assess the risk factors of malaria prevalence and bed net use among primary school children in mainland Tanzania. This allowed the mapping of malaria pre... Authors: Frank Chacky, Manuela Runge, Susan F. Rumisha, Pendael Machafuko, Prosper Chaki, Julius J. Massaga, Ally Mohamed, Emilie Pothin, Fabrizio Molteni, Robert W. Snow, Christian Lengeler and Renata Mandike Citation: Malaria Journal 2018 17:452 Published on: 5 December 2018 Treatments used for malaria in young Ethiopian children: a retrospective study In Ethiopia, medicinal plants have been used to treat different diseases, including malaria, for many centuries. People living in rural areas are especially noted for their use of medicinal plants as a major c... Authors: Abyot Endale Gurmu, Teresa Kisi, Habteweld Shibru, Bertrand Graz and Merlin Willcox Citation: Malaria Journal 2018 17:451 Published on: 5 December 2018 Accuracy of one Step malaria rapid diagnostic test (RDT) in detecting Plasmodium falciparum placental malaria infection in women living in Yaoundé, Cameroon Plasmodium falciparum infected erythrocytes sequestering in placental tissue release Plasmodium lactate dehydrogenase (pLDH) and histidine-rich protein-II (HRP-II). These proteins can be detected in peripheral bl... Authors: Rosette Megnekou, Jean Claude Djontu, Benderli C. Nana, Jude D. Bigoga, Maurice Fotso, Balotin Fogang and Rose F. G. Leke Citation: Malaria Journal 2018 17:450 Published on: 4 December 2018 Malaria case investigation with reactive focal testing and treatment: operational feasibility and lessons learned from low and moderate transmission areas in Amhara Region, Ethiopia When malaria transmission is very low, investigation of passively detected malaria cases and reactive focal testing and treatment (FTAT) in the case and neighbouring households can identify and contain the sou... Authors: Pooja Bansil, Asnakew K. Yeshiwondim, Caterina Guinovart, Belendia Serda, Callie Scott, Berhane H. Tesfay, Adem Agmas, Belay Bezabih, Melkamu T. Zeleke, Girma S. Guesses, Asmamaw L. Ayenew, Worku M. Workie, Duncan Earle, Rick W. Steketee and Asefaw Getachew Citation: Malaria Journal 2018 17:449 Published on: 4 December 2018 Spontaneous splenic rupture in Plasmodium knowlesi malaria Plasmodium knowlesi, a malaria parasite typically found in long-tailed and pig-tailed macaques, is the most common cause of human malaria in Malaysian Borneo. Infections in humans result in a spectrum of disease,... Authors: Chee Yik Chang, Wei Chieng Pui, Khamisah Abdul Kadir and Balbir Singh Citation: Malaria Journal 2018 17:448 Published on: 4 December 2018 Diversity analysis of MSP1 identifies conserved epitope organization in block 2 amidst high sequence variability in Indian Plasmodium falciparum isolates Despite its immunogenicity, the polymorphic nature of merozoite surface protein 1, an important vaccine candidate for Plasmodium falciparum malaria, remains a concern. This study analyses the impact of genetic va... Authors: Sharmistha Ghoshal, Pragya Gajendra, Sumana Datta Kanjilal, Mitashree Mitra and Sanghamitra Sengupta Citation: Malaria Journal 2018 17:447 Published on: 3 December 2018 Comparing the un-comparable: Olyset Plus and Olyset, different malaria impact In a recent article in The Lancet, Protopopoff et al. stated that insecticide resistance must be tackled and concluded that adding the insecticide synergist piperonyl butoxide (PBO) to a bed net with a pyrethroid... Authors: Ole Skovmand Citation: Malaria Journal 2018 17:446 Published on: 30 November 2018 Dry season occurrence of Anopheles mosquitoes and implications in Jabi Tehnan District, West Gojjam Zone, Ethiopia Generating evidence on the dry season occurrence of the larval and adult stages of Anopheles mosquitoes helps to design effective malaria vector control strategy as the populations of the vectors is expected to b... Authors: Abebe Animut and Yohannes Negash Citation: Malaria Journal 2018 17:445 Published on: 29 November 2018 A new approach to gathering pharmaceutical market data to support policy implementation and access to medicines: as demonstrated by malaria medicines in Zambia The steady supply of quality, affordable medicines is a pillar of a functioning health system. In addition to the public sector, the private, mission and not-for-profit sectors often serve a large part of the ... Authors: Renia Coghlan, Peter Stephens, Bernice Mwale and Makomani Siyanga Citation: Malaria Journal 2018 17:444 Published on: 29 November 2018 Area of exposure and treatment challenges of malaria in Eritrean migrants: a GeoSentinel analysis Recent reports highlight malaria as a frequent diagnosis in migrants who originate from Eritrea. A descriptive analysis of GeoSentinel cases of malaria in Eritrean migrants was done together with a literature ... Authors: Patricia Schlagenhauf, Martin P. Grobusch, Davidson H. Hamer, Hilmir Asgeirsson, Mogens Jensenius, Gilles Eperon, Camilla Rothe, Egon Isenring, Jan Fehr, Eli Schwartz, Emmanuel Bottieau, Elizabeth D. Barnett, Anne McCarthy, Paul Kelly, Carsten Schade Larsen, Perry van Genderen? Citation: Malaria Journal 2018 17:443 Published on: 29 November 2018 Within-population genetic diversity and population structure of Plasmodium knowlesi merozoite surface protein 1 gene from geographically distinct regions of Malaysia and Thailand The C-terminal 42 kDa domain of Plasmodium knowlesi merozoite surface protein 1 (PkMSP1) is a potential asexual blood-stage vaccine candidate, however, only a limited number of clinical isolates have been analyse... Authors: Md Atique Ahmed, Ki-Back Chu, Indra Vythilingam and Fu-Shi Quan Citation: Malaria Journal 2018 17:442 Published on: 29 November 2018 A multiplex assay for the sensitive detection and quantification of male and female Plasmodium falciparum gametocytes The transmission of malaria to mosquitoes depends on the presence of gametocytes that circulate in the peripheral blood of infected human hosts. Sensitive estimates of the densities of female gametocytes (FG) ... Authors: Lisette Meerstein-Kessel, Chiara Andolina, Elvira Carrio, Almahamoudou Mahamar, Patrick Sawa, Halimatou Diawara, Marga van de Vegte-Bolmer, Will Stone, Katharine A. Collins, Petra Schneider, Alassane Dicko, Chris Drakeley, Ingrid Felger, Till Voss, Kjerstin Lanke and Teun Bousema Citation: Malaria Journal 2018 17:441 Published on: 29 November 2018 Challenges for the diagnosis and treatment of malaria in low transmission settings in San Lorenzo, Esmeraldas, Ecuador Ecuador is on the verge of eliminating malaria according to the World Health Organization criteria. Nevertheless, active transmission foci still persist in the country, and these represent an important challen... Authors: Mayte Mosquera-Romero, Lina Zuluaga-Idárraga and Alberto Tobón-Castaño Citation: Malaria Journal 2018 17:440 Published on: 28 November 2018 Molecular identification of Plasmodium species responsible for malaria reveals Plasmodium vivax isolates in Duffy negative individuals from southwestern Nigeria Malaria in Nigeria is principally due to Plasmodium falciparum and, to a lesser extent to Plasmodium malariae and Plasmodium ovale. Plasmodium vivax is thought to be absent in Nigeria in particular and sub-Sahara... Authors: Mary Aigbiremo Oboh, Aida Sadikh Badiane, Godwin Ntadom, Yaye Die Ndiaye, Khadim Diongue, Mamadou Alpha Diallo and Daouda Ndiaye Citation: Malaria Journal 2018 17:439 Published on: 28 November 2018 Outreach training and supportive supervision for malaria case management in Zambia: the effects of focused capacity building on indicators of diagnostic and clinical performance Accurate diagnosis of malaria and reduced reliance on presumptive treatment are crucial components of quality case management. From 2008 to 2012, the Improving Malaria Diagnostics project, in collaboration wit... Authors: Matt Worges, Nicole Whitehurst, Emanuel Yamo, Hawela Moonga, Joshua Yukich and Luis Benavente Citation: Malaria Journal 2018 17:438 Published on: 28 November 2018 Controlled release spatial repellent devices (CRDs) as novel tools against malaria transmission: a semi-field study in Macha, Zambia The emergence of mosquitoes that can avoid indoor-deployed interventions, such as treated bed nets and indoor residual spraying, threatens the mainstay of malaria control in Zambia. Furthermore, the requiremen... Authors: Jennifer C. Stevenson, Limonty Simubali, Twig Mudenda, Esther Cardol, Ulrich R. Bernier, Agustin Abad Vazquez, Philip E. Thuma, Douglas E. Norris, Melynda Perry, Daniel L. Kline, Lee W. Cohnstaedt, Pablo Gurman, Sebastian D?hers and Noel M. Elman Citation: Malaria Journal 2018 17:437 Published on: 26 November 2018 Aspidosperma pyrifolium, a medicinal plant from the Brazilian caatinga, displays a high antiplasmodial activity and low cytotoxicity Several species of Aspidosperma plants are referred to as remedies for the treatment of malaria, especially Aspidosperma nitidum. Aspidosperma pyrifolium, also a medicinal plant, is used as a natural anti-inflamm... Authors: Isabela P. Ceravolo, Carlos L. Zani, Flávio J. B. Figueiredo, Markus Kohlhoff, Antônio E. G. Santana and Antoniana U. Krettli Citation: Malaria Journal 2018 17:436 Published on: 26 November 2018 Brain swelling is independent of peripheral plasma cytokine levels in Malawian children with cerebral malaria Cerebral malaria (CM) is often fatal, and severe brain swelling is a predictor of CM-related mortality. CM is characterized by elevated circulating pro-inflammatory cytokines TNF and IFN-? and anti-inflammator... Authors: Visopo Harawa, Madi Njie, Anne Kessler, Augustine Choko, Benjamin Kumwenda, Sam Kampondeni, Michael Potchen, Kami Kim, Anthony Jaworowski, Terrie Taylor, Wilson Mandala, Karl Seydel and Stephen Rogerson Citation: Malaria Journal 2018 17:435 Published on: 26 November 2018 Lack of significant recovery of chloroquine sensitivity in Plasmodium falciparum parasites following discontinuance of chloroquine use in Papua New Guinea Chloroquine treatment for Plasmodium falciparum has been discontinued in almost all endemic regions due to the spread of resistant isolates. Reversal of chloroquine susceptibility after chloroquine discontinuatio... Authors: Makoto Sekihara, Shin-Ichiro Tachibana, Masato Yamauchi, Shoki Yatsushiro, Steven Tiwara, Naoyuki Fukuda, Mie Ikeda, Toshiyuki Mori, Makoto Hirai, Francis Hombhanje and Toshihiro Mita Citation: Malaria Journal 2018 17:434 Published on: 26 November 2018 Roll Back Malaria: an historical footnote Prompted by the 20th anniversary of Roll Back Malaria, the author recalls hypotheses concerning a major new initiative to control malaria in Africa put forward by WHO AFRO and the World Bank in 1996. These hyp... Authors: Sir Richard Feachem Citation: Malaria Journal 2018 17:433 Published on: 19 November 2018 Cross-sectional study on the adherence to malaria guidelines in lakeshore facilities of Buyende and Kaliro districts, Uganda Uganda adopted the Integrated Management of Malaria (IMM) guidelines, which require testing all suspected cases of malaria prior to treatment and which have been implemented throughout the country. However, ad... Authors: Henry Kaula, Sylvia Kiconco and Luigi Nuñez Citation: Malaria Journal 2018 17:432 Published on: 19 November 2018 Correction to: Mapping a Plasmodium transmission spatial suitability index in Solomon Islands: a malaria monitoring and control tool Following publication of the original article [1], one of the authors flagged that the images for Figs. 2 and 3 were swapped in the published article?Fig. 2 had the image meant for Fig. 3 and vice versa. Authors: Isabelle Jeanne, Lynda E. Chambers, Adna Kazazic, Tanya L. Russell, Albino Bobogare, Hugo Bugoro, Francis Otto, George Fafale and Amanda Amjadali Citation: Malaria Journal 2018 17:431 Published on: 19 November 2018 The original article was published in Malaria Journal 2018 17:381 Inter-sectoral approaches for the prevention and control of malaria among the mobile and migrant populations: a scoping review Malaria cases among mobile and migrant populations (MMPs) represent a large and important reservoir for transmission, if undetected or untreated. The objectives of this review were to identify which intersecto... Authors: Cho Naing, Maxine A. Whittaker and Marcel Tanner Citation: Malaria Journal 2018 17:430 Published on: 16 November 2018 Severe Plasmodium vivax malaria, HIV, tuberculosis co-infection in a Sri Lankan traveller: case management and challenges during the prevention of malaria reintroduction phase The country received malaria-free certification from WHO in September 2016, becoming only the second country in the WHO South East Asia region to be declared malaria-free. Imported malaria cases continue to be... Authors: Dewanee Ranaweera, R. M. J. Kanchana Rajapaksha, Priyanganie Silva, Raja Hettiarachchi, W. M. Kumudu T. de A. W. Gunasekera, Hemantha Herath and Deepika Fernando Citation: Malaria Journal 2018 17:429 Published on: 16 November 2018 Bayesian spatiotemporal analysis of malaria infection along an international border: Hlaingbwe Township in Myanmar and Tha-Song-Yang District in Thailand One challenge in moving towards malaria elimination is cross-border malaria infection. The implemented measures to prevent and control malaria re-introduction across the demarcation line between two countries ... Authors: Aung Minn Thway, Chawarat Rotejanaprasert, Jetsumon Sattabongkot, Siam Lawawirojwong, Aung Thi, Tin Maung Hlaing, Thiha Myint Soe and Jaranit Kaewkungwal Citation: Malaria Journal 2018 17:428 Published on: 16 November 2018 Real time PCR detection of common CYP2D6 genetic variants and its application in a Karen population study Plasmodium vivax malaria is characterized by relapses arising from the hypnozoite stages in the liver. The only currently registered drug for radical treatment to prevent relapse is primaquine. Primaquine, a prod... Authors: Kanokpich Puaprasert, Cindy Chu, Naowarat Saralamba, Nicholas P. J. Day, Francois Nosten, Nicholas J. White, Arjen M. Dondorp and Mallika Imwong Citation: Malaria Journal 2018 17:427 Published on: 15 November 2018 Levels of human proteins in plasma associated with acute paediatric malaria The intimate interaction between the pathophysiology of the human host and the biology of the Plasmodium falciparum parasite results in a wide spectrum of disease outcomes in malaria. Development of severe diseas... Authors: Philippa Reuterswärd, Sofia Bergström, Judy Orikiiriza, Elisabeth Lindquist, Sven Bergström, Helene Andersson Svahn, Burcu Ayoglu, Mathias Uhlén, Mats Wahlgren, Johan Normark, Ulf Ribacke and Peter Nilsson Citation: Malaria Journal 2018 17:426 Published on: 15 November 2018 Fear and rumours regarding placental biopsies in a malaria-in-pregnancy trial in Benin A multi-country, community-based trial on scheduled screening and treatment for malaria in pregnancy was conducted in Benin, The Gambia and Burkina Faso. Despite standardized procedures and outcomes, the study... Authors: Adélaïde Compaoré, Susan Dierickx, Fatou Jaiteh, Alain Nahum, Towanou Francis Emmanuel Bohissou, Halidou Tinto, Susana Scott, Umberto D?Alessandro, Henk Schallig and Koen Peeters Grietens Citation: Malaria Journal 2018 17:425 Published on: 15 November 2018 Impact evaluation of malaria control interventions on morbidity and all-cause child mortality in Mali, 2000?2012 Major investments have been made since 2001, with intensification of malaria control interventions after 2006. Interventions included free distribution of insecticide-treated nets (ITN) to pregnant women and chil... Authors: Kassoum Kayentao, Lia S. Florey, Jules Mihigo, Abdoul Doumbia, Aliou Diallo, Diakalia Koné, Ogobara Doumbo and Erin Eckert Citation: Malaria Journal 2018 17:424 Published on: 14 November 2018 Age and gender trends in insecticide-treated net use in sub-Saharan Africa: a multi-country analysis The degree to which insecticide-treated net (ITN) supply accounts for age and gender disparities in ITN use among household members is unknown. This study explores the role of household ITN supply in the varia... Authors: Bolanle Olapeju, Ifta Choiriyyah, Matthew Lynch, Angela Acosta, Sean Blaufuss, Eric Filemyr, Hunter Harig, April Monroe, Richmond Ato Selby, Albert Kilian and Hannah Koenker Citation: Malaria Journal 2018 17:423 Published on: 14 November 2018 ResistanceSim: development and acceptability study of a serious game to improve understanding of insecticide resistance management in vector control programmes The use of insecticides is the cornerstone of effective malaria vector control. However, the last two decades has seen the ubiquitous use of insecticides, predominantly pyrethroids, causing widespread insectic... Authors: Edward K. Thomsen, Charlotte Hemingway, Andy South, Kirsten A. Duda, Claire Dormann, Robert Farmer, Michael Coleman and Marlize Coleman Citation: Malaria Journal 2018 17:422 Published on: 13 November 2018 LLIN Evaluation in Uganda Project (LLINEUP): factors associated with ownership and use of long-lasting insecticidal nets in Uganda: a cross-sectional survey of 48 districts Long-lasting insecticidal nets (LLINs) are a key malaria control intervention. To investigate factors associated with ownership and use of LLINs in Uganda, a cross-sectional community survey was conducted in M... Authors: Samuel Gonahasa, Catherine Maiteki-Sebuguzi, Sheila Rugnao, Grant Dorsey, Jimmy Opigo, Adoke Yeka, Agaba Katureebe, Mary Kyohere, Amy Lynd, Janet Hemingway, Martin Donnelly, Moses R. Kamya and Sarah G. Staedke Citation: Malaria Journal 2018 17:421 Published on: 13 November 2018 Correlation of malaria parasitaemia with peripheral blood monocyte to lymphocyte ratio as indicator of susceptibility to severe malaria in Ghanaian children Even though malaria is generally on the decline due extensive control and elimination efforts, it still remains a public health problem for over 40% of the world?s population. During the course of malaria infe... Authors: Samuel Antwi-Baffour, Ransford Kyeremeh, Dorcas Buabeng, Jonathan Kofi Adjei, Claudia Aryeh, George Kpentey and Mahmood Abdulai Seidu Citation: Malaria Journal 2018 17:419 Published on: 12 November 2018 Malaria epidemiology in Suriname from 2000 to 2016: trends, opportunities and challenges for elimination Suriname has experienced a significant change in malaria transmission risk and incidence over the past years. The country is now moving toward malaria elimination. The first objective of this study is to descr... Authors: Hélène Hiwat, Beatriz Martínez-López, Hedley Cairo, Loretta Hardjopawiro, Agatha Boerleider, Elisabeth Carmen Duarte and Zaida E. Yadon Citation: Malaria Journal 2018 17:418 Published on: 12 November 2018 Social determinants of malaria in an endemic area of Indonesia Malaria is an increasing concern in Indonesia. Socio-demographic factors were found to strongly influence malaria prevalence. This research aimed to explore the associations between socio-demographic factors a... Authors: Hamzah Hasyim, Pat Dale, David A. Groneberg, Ulrich Kuch and Ruth Müller Citation: Malaria Journal 2019 18:134 Published on: 12 April 2019 Comparison of malaria treatment outcome of generic and innovator?s anti-malarial drugs containing artemether?lumefantrine combination in the management of uncomplicated malaria amongst Tanzanian children In 2006, artemether?lumefantrine (ALU), specifically Coartem® (Novartis Pharma AG, Basel Switzerland), was approved as the first-line drug for treatment of uncomplicated malaria in Tanzania. Due to poor availabil... Authors: Manase Kilonzi, Omary Minzi, Ritah Mutagonda, Philip Sasi, Appolinary Kamuhabwa and Eleni Aklillu Citation: Malaria Journal 2019 18:133 Published on: 11 April 2019 HSP superfamily of genes in the malaria vector Anopheles sinensis: diversity, phylogenetics and association with pyrethroid resistance Heat shock proteins (HSPs) are molecular chaperones that are involved in many normal cellular processes and various kinds of environmental stress. There is still no report regarding the diversity and phylogene... Authors: Feng-Ling Si, Liang Qiao, Qi-Yi He, Yong Zhou, Zhen-Tian Yan and Bin Chen Citation: Malaria Journal 2019 18:132 Published on: 11 April 2019 Modification of contact avoidance behaviour associated with pyrethroid resistance in Anopheles sinensis (Diptera: Culicidae) Anopheles sinensis is the primary vector of vivax malaria in China and its control is under great threat as the development of insecticide resistance. In contrast to physiological resistance, there is no report o... Authors: Zhengbo He, Jing Zhang, Zongpan Shi, Jingang Liu, Jingjing Zhang, Zhentian Yan and Bin Chen Citation: Malaria Journal 2019 18:131 Published on: 11 April 2019 Distribution of Plasmodium species and assessment of performance of diagnostic tools used during a malaria survey in Southern and Western Provinces of Zambia Zambia continues to make strides in reducing malaria burden through the use of proven malaria interventions and has recently pledged to eliminate malaria by 2021. Case management services have been scaled up a... Authors: Lungowe Sitali, John M. Miller, Mulenga C. Mwenda, Daniel J. Bridges, Moonga B. Hawela, Busiku Hamainza, Elizabeth Chizema-Kawesha, Thomas P. Eisele, James Chipeta and Bernt Lindtjørn Citation: Malaria Journal 2019 18:130 Published on: 11 April 2019 Genetic variation of avian malaria in the tropical Andes: a relationship with the spatial distribution of hosts Avian haemosporidia are obligate blood parasites with an ample range of hosts worldwide. To understand how host communities may influence the diversity of parasites of the neotropics, the spatial genetic varia... Authors: Diana Lorena Gil-Vargas and Raul Ernesto Sedano-Cruz Citation: Malaria Journal 2019 18:129 Published on: 11 April 2019 Age-dependent increase in antibodies that inhibit Plasmodium falciparum adhesion to a subset of endothelial receptors Plasmodium falciparum-infected erythrocytes (IE) sequester in deep vascular beds where their adhesion is mediated by an array of endothelial surface receptors. Because parasite adhesion has been associated with d... Authors: Oumar Attaher, Almahamoudou Mahamar, Bruce Swihart, Amadou Barry, Bacary S. Diarra, Moussa B. Kanoute, Adama B. Dembele, Sekouba Keita, Santara Gaoussou, Djibrilla Issiaka, Alassane Dicko, Patrick E. Duffy and Michal Fried Citation: Malaria Journal 2019 18:128 Published on: 11 April 2019 Introgression between Anopheles gambiae and Anopheles coluzzii in Burkina Faso and its associations with kdr resistance and Plasmodium infection Insecticide resistance in Anopheles coluzzii mosquitoes has become widespread throughout West Africa including in Burkina Faso. The insecticide resistance allele (kdr or L1014F) is a prime indicator that is highl... Authors: Mark J. Hanemaaijer, Hannah Higgins, Ipek Eralp, Youki Yamasaki, Norbert Becker, Oscar D. Kirstein, Gregory C. Lanzaro and Yoosook Lee Citation: Malaria Journal 2019 18:127 Published on: 11 April 2019 African isolates show a high proportion of multiple copies of the Plasmodium falciparum plasmepsin-2 gene, a piperaquine resistance marker Today, the development of new and well-tolerated anti-malarial drugs is strongly justified by the emergence of Plasmodium falciparum resistance. In 2014?2015, a phase 2b clinical study was conducted to evaluate t... Authors: Didier Leroy, Fiona Macintyre, Yeka Adoke, Serge Ouoba, Aissata Barry, Ghyslain Mombo-Ngoma, Jacques Mari Ndong Ngomo, Rosauro Varo, Yannelle Dossou, Antoinette Kitoto Tshefu, Tran Thanh Duong, Bui Quang Phuc, Bart Laurijssens, Roland Klopper, Nimol Khim, Eric Legrand? Citation: Malaria Journal 2019 18:126 Published on: 10 April 2019 Correction to: Use and retention of long-lasting insecticidal nets (LLINs) in a malaria risk area in the Brazilian Amazon: a 5-year follow-up intervention Following publication of the original article [1], the corresponding author flagged that the particle ?de? in their name had been placed incorrectly. Authors: Jessica de Oliveira Sousa, Bernardino Claudio de Albuquerque, José Rodrigues Coura and Martha Cecilia Suárez-Mutis Citation: Malaria Journal 2019 18:125 Published on: 9 April 2019 The original article was published in Malaria Journal 2019 18:100 Epidemiological profiles of recurrent malaria episodes in an endemic area along the Thailand-Myanmar border: a prospective cohort study In low malaria transmission areas, many people acquire multiple malaria infections within a single season. This study aimed to describe the pattern and epidemiological profile of malaria recurrence in a hypoen... Authors: Saranath Lawpoolsri, Jetsumon Sattabongkot, Jeeraphat Sirichaisinthop, Liwang Cui, Kirakorn Kiattibutr, Nattawan Rachaphaew, Kritsana Suk-uam, Amnat Khamsiriwatchara and Jaranit Kaewkungwal Citation: Malaria Journal 2019 18:124 Published on: 8 April 2019 View Full Text View PDF Content type: Commentary· Positive direct antiglobulin test in post-artesunate delayed haemolysis: more than a coincidence? Delayed haemolysis is a frequent adverse event after treatment with artesunate (AS). Removing once-infected ?pitted? erythrocytes by the spleen is the most accepted mechanism of haemolysis in these cases. Howe... Authors: Daniel Camprubí, Arturo Pereira, Natalia Rodriguez-Valero, Alex Almuedo, Rosauro Varo, Climent Casals-Pascual, Quique Bassat, Denis Malvy and Jose Muñoz Citation: Malaria Journal 2019 18:123 Published on: 8 April 2019 Prioritizing the scale-up of interventions for malaria control and elimination A core set of intervention and treatment options are recommended by the World Health Organization for use against falciparum malaria. These are treatment, long-lasting insecticide-treated bed nets, indoor resi... Authors: Peter Winskill, Patrick G. Walker, Richard E. Cibulskis and Azra C. Ghani Citation: Malaria Journal 2019 18:122 Published on: 8 April 2019 Caregiver exposure to malaria social and behaviour change messages can improve bed net use among children in an endemic country: secondary analysis of the 2015 Nigeria Malaria Indicator Survey To reduce the malaria burden in Nigeria, the National Malaria Strategic Plan (NMSP) 2014?2020 calls for the scale-up of prevention and treatment interventions, including social and behaviour change (SBC). SBC ... Authors: Kirsten Zalisk, Samantha Herrera, Uwem Inyang, Audu Bala Mohammed, Perpetua Uhomoibhi and Yazoumé Yé Citation: Malaria Journal 2019 18:121 Published on: 6 April 2019 Detection of alleles associated with resistance to chemical insecticide in the malaria vector Anopheles arabiensis in Santiago, Cabo Verde Mosquitoes of the Anopheles gambiae complex are the main malaria vectors worldwide. Due to the lack of a vaccine to prevent malaria, the principal way to reduce the impact of this disease relies on the use of che... Authors: Derciliano Lopes da Cruz, Marcelo Henrique Santos Paiva, Duschinka Ribeiro Duarte Guedes, Joana Alves, Lara Ferrero Gómez and Constância Flávia Junqueira Ayres Citation: Malaria Journal 2019 18:120 Published on: 5 April 2019 In vitro and in vivo studies on anti-malarial activity of Commiphora africana and Dichrostachys cinerea used by the Maasai in Arusha region, Tanzania Traditional medicinal plants are one of the potential sources of anti-malarial drugs and there is an increasing interest in the use and development of traditional herbal remedies for the treatment of malaria a... Authors: Prisca A. Kweyamba, Denis Zofou, Noella Efange, Jules-Clement N. Assob, Jovin Kitau and Mramba Nyindo Citation: Malaria Journal 2019 18:119 Published on: 4 April 2019 Individual and contextual factors predicting self-reported malaria among adults in eastern Indonesia: findings from Indonesian community-based survey Malaria is still an important parasitic infectious disease that affecting poor and vulnerable communities in many developing countries, including Indonesia. During the period of 2010?2017, there have been appr... Authors: Pandji Wibawa Dhewantara, Mara Ipa and Mutiara Widawati Citation: Malaria Journal 2019 18:118 Published on: 4 April 2019 Vector competence, vectorial capacity of Nyssorhynchus darlingi and the basic reproduction number of Plasmodium vivax in agricultural settlements in the Amazonian Region of Brazil Brazilian malaria control programmes successfully reduced the incidence and mortality rates from 2005 to 2016. Since 2017, increased malaria has been reported across the Amazon. Few field studies focus on the ... Authors: Maria Anice M. Sallum, Jan E. Conn, Eduardo S. Bergo, Gabriel Z. Laporta, Leonardo S. M. Chaves, Sara A. Bickersmith, Tatiane M. P. de Oliveira, Elder Augusto G. Figueira, Gilberto Moresco, Lêuda Olívêr, Claudio J. Struchiner, Laith Yakob and Eduardo Massad Citation: Malaria Journal 2019 18:117 Published on: 4 April 2019 Sensitive real-time PCR detection of Plasmodium falciparum parasites in whole blood by erythrocyte membrane protein 1 gene amplification Malaria remains a global public health problem responsible for 445,000 deaths in 2016. While microscopy remains the mainstay of malaria diagnosis, highly sensitive molecular methods for detection of low-grade ... Authors: Bryan Grabias, Edward Essuman, Isabella A. Quakyi and Sanjai Kumar Citation: Malaria Journal 2019 18:116 Published on: 2 April 2019 Care-seeking behaviour and treatment practices for malaria in children under 5 years in Mozambique: a secondary analysis of 2011 DHS and 2015 IMASIDA datasets In Mozambique, the prevalence of malaria in children under 5 years of age is among the highest in the world, but limited data exist on determinants of care-seeking behaviour for malaria. This study aimed at de... Authors: Annette Cassy, Abuchahama Saifodine, Baltazar Candrinho, Maria do Rosário Martins, Saraiva da Cunha, Filomena Martins Pereira and Eduardo Samo Gudo Citation: Malaria Journal 2019 18:115 Published on: 2 April 2019 Polymorphisms in Pvkelch12 and gene amplification of Pvplasmepsin4 in Plasmodium vivax from Thailand, Lao PDR and Cambodia Mutations in Pfkelch13 and Pfplasmepsin2/3 gene amplification are well-established markers for artemisinin and piperaquine resistance in Plasmodium falciparum, a widespread problem in the Greater Mekong Subregion... Authors: Jureeporn Duanguppama, Vivek Bhakta Mathema, Rupam Tripura, Nicholas P. J. Day, Mayfong Maxay, Chea Nguon, Lorenz von Seidlein, Mehul Dhorda, Thomas J. Peto, Francois Nosten, Nicholas J. White, Arjen M. Dondorp and Mallika Imwong Citation: Malaria Journal 2019 18:114 Published on: 2 April 2019 Seasonal malaria vector and transmission dynamics in western Burkina Faso In the context of widespread mosquito resistance to currently available pesticides, novel, precise genetic vector control methods aimed at population suppression or trait replacement are a potentially powerful... Authors: Patric Stephane Epopa, Catherine Matilda Collins, Ace North, Abdoul Azize Millogo, Mark Quentin Benedict, Frederic Tripet and Abdoulaye Diabate Citation: Malaria Journal 2019 18:113 Published on: 2 April 2019 Influence of blood meal and age of mosquitoes on susceptibility to pyrethroids in Anopheles gambiae from Western Kenya Physiological characteristics (age and blood feeding status) of malaria vectors can influence their susceptibility to the current vector control tools that target their feeding and resting behaviour. To ensure... Authors: Maxwell G. Machani, Eric Ochomo, David Sang, Mariangela Bonizzoni, Guofa Zhou, Andrew K. Githeko, Guiyun Yan and Yaw A. Afrane Citation: Malaria Journal 2019 18:112 Published on: 2 April 2019 Safety of primaquine in infants with Plasmodium vivax malaria in Papua, Indonesia Primaquine (PQ) prevents relapses of vivax malaria but may induce severe haemolysis in glucose-6-phosphate dehydrogenase (G6PD) deficient patients. Data on the safety of primaquine in infants are limited. Authors: Agus Setyadi, Eggi Arguni, Enny Kenangalem, Afdhal Hasanuddin, Daniel A. Lampah, Kamala Thriemer, Nicholas M. Anstey, Paulus Sugiarto, Julie A. Simpson, Ric N. Price, Nicholas M. Douglas and Jeanne R. Poespoprodjo Citation: Malaria Journal 2019 18:111 Published on: 2 April 2019 Effects of anthropogenic landscape changes on the abundance and acrodendrophily of Anopheles (Kerteszia) cruzii, the main vector of malaria parasites in the Atlantic Forest in Brazil The mosquito Anopheles (Kerteszia) cruzii is the main vector of human and simian malaria in the Atlantic Forest. This species is usually abundant in the forests where it occurs, preferring to live and feed on can... Authors: Antônio Ralph Medeiros-Sousa, Rafael de Oliveira Christe, Ana Maria Ribeiro de Castro Duarte, Luis Filipe Mucci, Walter Ceretti-Junior and Mauro Toledo Marrelli Citation: Malaria Journal 2019 18:110 Published on: 2 April 2019 Non-invasive surveillance of Plasmodium infection by real-time PCR analysis of ethanol preserved faeces from Ugandan school children with intestinal schistosomiasis As part of ongoing co-surveillance of intestinal schistosomiasis and malaria in Ugandan school children, a non-invasive detection method for amplification of Plasmodium DNA using real-time (rt)PCR analysis of eth... Authors: Hajri Al-Shehri, B. Joanne Power, John Archer, Alice Cousins, Aaron Atuhaire, Moses Adriko, Moses Arinaitwe, Abdullah D. Alanazi, E. James LaCourse, Narcis B. Kabatereine and J. Russell Stothard Citation: Malaria Journal 2019 18:109 Published on: 1 April 2019 Assessing Kwa-Zulu-Natal?s progress towards malaria elimination and its readiness for sub-national verification The South African province of KwaZulu-Natal is rapidly approaching elimination status for malaria with a steady decline in local cases. With the possibility of achieving elimination in reach, the KZN malaria c... Authors: Ryleen Balawanth, Inessa Ba, Bheki Qwabe, Laura Gast, Rajendra Maharaj, Jaishree Raman, Rebecca Graffy, Mbavhalelo Shandukani and Devanand Moonasar Citation: Malaria Journal 2019 18:108 Published on: 1 April 2019 Changing epidemiology and challenges of malaria in China towards elimination Historically, malaria had been a widespread disease in China. A national plan was launched in China in 2010, aiming to eliminate malaria by 2020. In 2017, no indigenous cases of malaria were detected in China ... Authors: Shengjie Lai, Junling Sun, Nick W. Ruktanonchai, Sheng Zhou, Jianxing Yu, Isobel Routledge, Liping Wang, Yaming Zheng, Andrew J. Tatem and Zhongjie Li Citation: Malaria Journal 2019 18:107 Published on: 29 March 2019 Molecular epidemiology of residual Plasmodium vivax transmission in a paediatric cohort in Solomon Islands Following the scale-up of intervention efforts, malaria burden has decreased dramatically in Solomon Islands (SI). Submicroscopic and asymptomatic Plasmodium vivax infections are now the major challenge for malar... Authors: Yi Wan Quah, Andreea Waltmann, Stephan Karl, Michael T. White, Ventis Vahi, Andrew Darcy, Freda Pitakaka, Maxine Whittaker, Daniel J. Tisch, Alyssa Barry, Celine Barnadas, James Kazura and Ivo Mueller Citation: Malaria Journal 2019 18:106 Published on: 28 March 2019 Artemisinin-based combination therapy during pregnancy: outcome of pregnancy and infant mortality: a cohort study The World Health Organization (WHO) recommendation of treating uncomplicated malaria during the second and third trimester of pregnancy with an artemisinin-based combination therapy (ACT) has already been impl... Authors: Michael Nambozi, Halidou Tinto, Victor Mwapasa, Harry Tagbor, Jean-Bertin Bukasa Kabuya, Sebastian Hachizovu, Maminata Traoré, Innocent Valea, Marc Christian Tahita, Gifty Ampofo, Jozefien Buyze, Raffaella Ravinetto, Diana Arango, Kamala Thriemer, Modest Mulenga, Jean-Pierre van Geertruyden? Citation: Malaria Journal 2019 18:105 Published on: 28 March 2019 Accuracy of malaria diagnosis by clinical laboratories in Belgium The Belgian Reference Laboratory for Plasmodium offers a free-of-charge reference testing of malaria-positive or doubtful samples to clinical laboratories. Authors: Laura Loomans, Anali Conesa Botella, Agnes D?hondt, Jacob Verschueren, Dorien Van den Bossche, Marjan Van Esbroeck and Jan Jacobs Citation: Malaria Journal 2019 18:104 Published on: 28 March 2019 Malaria testing and treatment knowledge among selected rural patent and proprietary medicine vendors (PPMV) in Nigeria Malaria is a leading cause of illness and death in Nigeria, but access of poor people to quality anti-malarial services remains low especially in the rural areas. Patent and proprietary medicine vendors (PPMVs... Authors: Oladimeji Oladepo, Abisoye S. Oyeyemi, Musibau A. Titiloye, Adedayo O. Adeyemi, Sarah M. Burnett, Iorwakwagh Apera, Opeyemi Oladunni and Michael Alliu Citation: Malaria Journal 2019 18:103 Published on: 27 March 2019 Dynamics and monitoring of insecticide resistance in malaria vectors across mainland Tanzania from 1997 to 2017: a systematic review Malaria still claims substantial lives of individuals in Tanzania. Insecticide-treated nets (ITNs) and indoor residual spray (IRS) are used as major malaria vector control tools. These tools are facing great c... Authors: Deokary Joseph Matiya, Anitha B. Philbert, Winifrida Kidima and Johnson J. Matowo Citation: Malaria Journal 2019 18:102 Published on: 26 March 2019 High prevalence of Pfdhfr?Pfdhps quadruple mutations associated with sulfadoxine?pyrimethamine resistance in Plasmodium falciparum isolates from Bioko Island, Equatorial Guinea Sulfadoxine?pyrimethamine (SP) is recommended for intermittent preventive treatment of malaria in Africa. However, increasing SP resistance (SPR) affects the therapeutic efficacy of the SP. As molecular markers, Authors: Tingting Jiang, Jiangtao Chen, Hongxia Fu, Kai Wu, Yi Yao, Juan Urbano Monsuy Eyi, Rocio Apicante Matesa, Maximo Miko ondo Obono, Weixing Du, Huabing Tan, Min Lin and Jian Li Citation: Malaria Journal 2019 18:101 Published on: 26 March 2019 Use and retention of long-lasting insecticidal nets (LLINs) in a malaria risk area in the Brazilian Amazon: a 5-year follow-up intervention Long-lasting insecticidal nets (LLINs) are one of the main vector control strategies recommended by the World Health Organization for the control and elimination of malaria. This study aimed to evaluate the us... Authors: Jessica de Oliveira Sousa, Bernardino Claudio de Albuquerque, José Rodrigues Coura and Martha Cecilia Suárez-Mutis Citation: Malaria Journal 2019 18:100 Published on: 25 March 2019 The Correction to this article has been published in Malaria Journal 2019 18:125 High cure rates and tolerability of artesunate?amodiaquine and dihydroartemisinin?piperaquine for the treatment of uncomplicated falciparum malaria in Kibaha and Kigoma, Tanzania The Tanzanian National Malaria Control Programme (NMCP) and its partners have been implementing regular therapeutic efficacy studies (TES) to monitor the performance of different drugs used or with potential u... Authors: Celine I. Mandara, Filbert Francis, Mercy G. Chiduo, Billy Ngasala, Renata Mandike, Sigsbert Mkude, Frank Chacky, Fabrizio Molteni, Ritha Njau, Ally Mohamed, Marian Warsame and Deus S. Ishengoma Citation: Malaria Journal 2019 18:99 Published on: 25 March 2019 Field evaluation of malaria malachite green loop-mediated isothermal amplification in health posts in Roraima state, Brazil Microscopic detection of malaria parasites is the standard method for clinical diagnosis of malaria in Brazil. However, malaria epidemiological surveillance studies specifically aimed at the detection of low-d... Authors: Heather M. Kudyba, Jaime Louzada, Dragan Ljolje, Karl A. Kudyba, Vasant Muralidharan, Joseli Oliveira-Ferreira and Naomi W. Lucchi Citation: Malaria Journal 2019 18:98 Published on: 25 March 2019 Does reduced oxygen delivery cause lactic acidosis in falciparum malaria? An observational study Lactic acidosis with an elevated lactate?pyruvate ratio suggesting anoxia is a common feature of severe falciparum malaria. High lactate levels are associated with parasitized erythrocyte sequestration in the ... Authors: Hugh W. Kingston, Aniruddha Ghose, Voravut Rungpradubvong, M. Trent Herdman, Katherine Plewes, Haruhiko Ishioka, Stije J. Leopold, Richard J. Maude, Benjamas Intharabut, Sanjib Mohanty, Nicholas P. J. Day, Nicholas J. White, Md Amir Hossain, Nicholas M. Anstey and Arjen M. Dondorp Citation: Malaria Journal 2019 18:97 Published on: 25 March 2019 Species abundance, composition, and nocturnal activity of female Anopheles (Diptera: Culicidae) in malaria-endemic villages of Papua New Guinea: assessment with barrier screen sampling Community composition of Anopheles mosquitoes, and their host-seeking and peridomestic behaviour, are important factors affecting malaria transmission. In this study, barrier screen sampling was used to investiga... Authors: John B. Keven, Michelle Katusele, Rebecca Vinit, Gussy Koimbu, Naomi Vincent, Edward K. Thomsen, Stephan Karl, Lisa J. Reimer and Edward D. Walker Citation: Malaria Journal 2019 18:96 Published on: 25 March 2019 Application of matrix-assisted laser desorption/ionization mass spectrometry to identify species of Neotropical Anopheles vectors of malaria Malaria control in Panama is problematic due to the high diversity of morphologically similar Anopheles mosquito species, which makes identification of vectors of human Plasmodium challenging. Strategies by Panam... Authors: Jose R. Loaiza, Alejandro Almanza, Juan C. Rojas, Luis Mejía, Norma D. Cervantes, Javier E. Sanchez-Galan, Fernando Merchán, Arnaud Grillet, Matthew J. Miller, Luis F. De León and Rolando A. Gittens Citation: Malaria Journal 2019 18:95 Published on: 22 March 2019 Two successful decades of Swiss collaborations to develop new anti-malarials Over the last two decades there has been a renaissance in the pipeline of new drugs targeting malaria, with the launch of new products that help save the lives of children throughout the world. In addition, th... Authors: Rob Hooft van Huijsduijnen, Timothy Wells, Marcel Tanner and Sergio Wittlin Citation: Malaria Journal 2019 18:94 Published on: 22 March 2019 The past, present and future of anti-malarial medicines Great progress has been made in recent years to reduce the high level of suffering caused by malaria worldwide. Notably, the use of insecticide-treated mosquito nets for malaria prevention and the use of artem... Authors: Edwin G. Tse, Marat Korsik and Matthew H. Todd Citation: Malaria Journal 2019 18:93 Published on: 22 March 2019 Knowledge of malaria prevention among pregnant women and non-pregnant mothers of children aged under 5 years in Ibadan, South West Nigeria Adequate knowledge of malaria prevention and control can help in reducing the growing burden of malaria among vulnerable groups, particularly pregnant women and children aged under 5 years living in malaria en... Authors: Kelechi Elizabeth Oladimeji, Joyce Mahlako Tsoka-Gwegweni, Elizabeth Ojewole and Samuel Tassi Yunga Citation: Malaria Journal 2019 18:92 Published on: 22 March 2019 Investigation of a possible malaria epidemic in an illegal gold mine in French Guiana: an original approach in the remote Amazonian forest In April 2017, Suriname?s Ministry of Health alerted French Guiana?s Regional Health Agency (RHA) about an increase of imported malaria cases among people coming from an illegal gold mining site called Sophie, in... Authors: Maylis Douine, Alice Sanna, Helene Hiwat, Sébastien Briolant, Mathieu Nacher, Didier Belleoud, François Michel Le Tourneau, Hervé Bogreau and Franck De Laval Citation: Malaria Journal 2019 18:91 Published on: 22 March 2019 A stakeholder workshop about modelled maps of key malaria indicator survey indicators in Madagascar The Demographic and Health Surveys (DHS) Program has supported three household Malaria Indicator Surveys (MIS) in Madagascar. The results of 13 key malaria indicators from these surveys have been mapped as con... Authors: Rosalind E. Howes, Kaleem Hawa, Voahangy Fanomezana Andriamamonjy, Thierry Franchard, Raharizo Miarimbola, Sedera Aurélien Mioramalala, Jean Florent Rafamatanantsoa, Mirana Ando Mbolatiana Rahantamalala, Solo Harimalala Rajaobary, Hariniaina David Gaël Rajaonera, Andrianiaina Parfait Rakotonindrainy, Clairaut Rakotoson Andrianjatonavalona, Dina Ny Aina Liantsoa Randriamiarinjatovo, Faratiana Michèle Randrianasolo, Rado Malalatiana Ramasy Razafindratovo, Masiarivony Ravaoarimanga? Citation: Malaria Journal 2019 18:90 Published on: 22 March 2019 Structure?activity relationships in a series of antiplasmodial thieno[2,3-b]pyridines Malaria is one of the most prevalent tropical infectious diseases. Since recently cases of artemisinin resistance were reported, novel anti-malarial drugs are required which differ from artemisinins in structu... Authors: Andreas Masch, Abed Nasereddin, Arne Alder, Megan J. Bird, Sandra I. Schweda, Lutz Preu, Christian Doerig, Ron Dzikowski, Tim W. Gilberger and Conrad Kunick Citation: Malaria Journal 2019 18:89 Published on: 21 March 2019 Efficacy and safety of artemether-lumefantrine for the treatment of uncomplicated malaria and prevalence of Pfk13 and Pfmdr1 polymorphisms after a decade of using artemisinin-based combination therapy in mainland Tanzania The World Health Organization recommends regular therapeutic efficacy studies (TES) to monitor the performance of first and second-line anti-malarials. In 2016, efficacy and safety of artemether-lumefantrine (... Authors: Deus S. Ishengoma, Celine I. Mandara, Filbert Francis, Eldin Talundzic, Naomi W. Lucchi, Billy Ngasala, Abdunoor M. Kabanywanyi, Muhidin K. Mahende, Erasmus Kamugisha, Reginald A. Kavishe, Florida Muro, Ally Mohamed, Renata Mandike, Sigsbert Mkude, Frank Chacky, Lynn Paxton? Citation: Malaria Journal 2019 18:88 Published on: 21 March 2019 Evaluation of a push?pull system consisting of transfluthrin-treated eave ribbons and odour-baited traps for control of indoor- and outdoor-biting malaria vectors Push?pull strategies have been proposed as options to complement primary malaria prevention tools, indoor residual spraying (IRS) and long-lasting insecticide-treated nets (LLINs), by targeting particularly ea... Authors: Arnold S. Mmbando, Elis P. A. Batista, Masoud Kilalangongono, Marceline F. Finda, Emmanuel P. Mwanga, Emmanuel W. Kaindoa, Khamis Kifungo, Rukiyah M. Njalambaha, Halfan S. Ngowo, Alvaro E. Eiras and Fredros O. Okumu Citation: Malaria Journal 2019 18:87 Published on: 20 March 2019 Short-term metabolic adjustments in Plasmodium falciparum counter hypoxanthine deprivation at the expense of long-term viability The malarial parasite Plasmodium falciparum is an auxotroph for purines, which are required for nucleic acid synthesis during the intra-erythrocytic developmental cycle (IDC) of the parasite. The capabilities of ... Authors: Shivendra G. Tewari, Krithika Rajaram, Patric Schyman, Russell Swift, Jaques Reifman, Sean T. Prigge and Anders Wallqvist Citation: Malaria Journal 2019 18:86 Published on: 19 March 2019 Detection of Plasmodium falciparum infected Anopheles gambiae using near-infrared spectroscopy Large-scale surveillance of mosquito populations is crucial to assess the intensity of vector-borne disease transmission and the impact of control interventions. However, there is a lack of accurate, cost-effe... Authors: Marta F. Maia, Melissa Kapulu, Michelle Muthui, Martin G. Wagah, Heather M. Ferguson, Floyd E. Dowell, Francesco Baldini and Lisa-Ranford Cartwright Citation: Malaria Journal 2019 18:85 Published on: 19 March 2019 ·Aminoacyl tRNA synthetases as malarial drug targets: a comparative bioinformatics study Treatment of parasitic diseases has been challenging due to evolution of drug resistant parasites, and thus there is need to identify new class of drugs and drug targets. Protein translation is important for s... Authors: Dorothy Wavinya Nyamai and Özlem Tastan Bishop Citation: Malaria Journal 2019 18:34 Published on: 6 February 2019 Correction to: Performance of an ultra-sensitive Plasmodium falciparum HRP2-based rapid diagnostic test with recombinant HRP2, culture parasites, and archived whole blood samples Following publication of the original article [1], the authors flagged an error concerning a reference to a product in the Methods section. Authors: Smita Das, Roger B. Peck, Rebecca Barney, Ihn Kyung Jang, Maria Kahn, Meilin Zhu and Gonzalo J. Domingo Citation: Malaria Journal 2019 18:33 Published on: 4 February 2019 The original article was published in Malaria Journal 2018 17:118 How can interventions that target forest-goers be tailored to accelerate malaria elimination in the Greater Mekong Subregion? A systematic review of the qualitative literature Despite decreases in incidence and related mortality, malaria remains a major public health challenge in the Greater Mekong Sub-region (GMS). The emergence of artemisinin resistance threatens these gains and h... Authors: Stephanie D. Nofal, Thomas J. Peto, Bipin Adhikari, Rupam Tripura, James Callery, Thanh Mai Bui, Lorenz von Seidlein and Christopher Pell Citation: Malaria Journal 2019 18:32 Published on: 1 February 2019 Genetic variability of Plasmodium falciparum histidine-rich proteins 2 and 3 in Central America Malaria is an important disease in many tropical countries. Rapid diagnostic tests (RDTs) are valuable tools for diagnosing malaria in remote areas. The majority of RDTs used for the diagnosis of Plasmodium falci... Authors: Gustavo Fontecha, Alejandra Pinto, Denis Escobar, Gabriela Matamoros and Bryan Ortiz Citation: Malaria Journal 2019 18:31 Published on: 31 January 2019 Formation primaquine-5,6-orthoquinone, the putative active and toxic metabolite of primaquine via direct oxidation in human erythrocytes The activity and haemolytic toxicity associated with primaquine has been linked to its reactive metabolites. The reactive metabolites are thought to be primarily formed through the action of cytochrome P450-media... Authors: Pius S. Fasinu, N. P. Dhammika Nanayakkara, Yan-Hong Wang, Narayan D. Chaurasiya, H. M. Bandara Herath, James D. McChesney, Bharathi Avula, Ikhlas Khan, Babu L. Tekwani and Larry A. Walker Citation: Malaria Journal 2019 18:30 Published on: 30 January 2019 Swarms of the malaria vector Anopheles funestus in Tanzania Anopheles funestus mosquitoes currently contribute more than 85% of ongoing malaria transmission events in south-eastern Tanzania, even though they occur in lower densities than other vectors, such as Anopheles a... Authors: Emmanuel W. Kaindoa, Halfan S. Ngowo, Alex J. Limwagu, Magellan Tchouakui, Emmanuel Hape, Said Abbasi, Japhet Kihonda, Arnold S. Mmbando, Rukiyah M. Njalambaha, Gustav Mkandawile, Hamis Bwanary, Maureen Coetzee and Fredros O. Okumu Citation: Malaria Journal 2019 18:29 Published on: 29 January 2019 Does artemether?lumefantrine administration affect mosquito olfactory behaviour and fitness? Artemisinin-based combination therapy (ACT) is the recommended treatment against uncomplicated Plasmodium falciparum infections, and ACT is widely used. It has been shown that gametocytes may be present after ACT... Authors: Jetske G. de Boer, Annette O. Busula, Jet ten Berge, Tessa S. van Dijk and Willem Takken Citation: Malaria Journal 2019 18:28 Published on: 28 January 2019 Community knowledge and acceptance of indoor residual spraying for malaria prevention in Mozambique: a qualitative study Malaria control remains a leading health challenge in Mozambique. Indoor residual spraying (IRS) is an effective strategy to control malaria transmission, but there are often barriers to reaching the coverage ... Authors: Amílcar Magaço, Carlos Botão, Pedroso Nhassengo, Mohomede Saide, Arminda Ubisse, Sérgio Chicumbe and Rose Zulliger Citation: Malaria Journal 2019 18:27 Published on: 25 January 2019 A fast and cost-effective microsampling protocol incorporating reduced animal usage for time-series transcriptomics in rodent malaria parasites The transcriptional regulation that occurs in malaria parasites during the erythrocytic stages of infection can be studied in vivo with rodent malaria parasites propagated in mice. Time-series transcriptome pr... Authors: Abhinay Ramaprasad, Amit Kumar Subudhi, Richard Culleton and Arnab Pain Citation: Malaria Journal 2019 18:26 Published on: 25 January 2019 Structure of Rhoptry Neck Protein 2 is essential for the interaction in vitro with Apical Membrane Antigen 1 in Plasmodium vivax In several Apicomplexa, the formation of moving junctions (MJs) at the interface between the external membranes of the invading parasite and the host cell is essential for the process of parasite invasion. In Pla... Authors: Perla Salgado-Mejias, Flavio L. Alves, Kátia S. Françoso, Karin A. Riske, Emerson R. Silva, Antonio Miranda and Irene S. Soares Citation: Malaria Journal 2019 18:25 Published on: 25 January 2019 Streamlined SMFA and mosquito dark-feeding regime significantly improve malaria transmission-blocking assay robustness and sensitivity The development of malaria transmission-blocking strategies including the generation of malaria refractory mosquitoes to replace the wild populations through means of gene drives hold great promise. The standa... Authors: Tibebu Habtewold, Sofia Tapanelli, Ellen K. G. Masters, Astrid Hoermann, Nikolai Windbichler and George K. Christophides Citation: Malaria Journal 2019 18:24 Published on: 25 January 2019
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