Malaria is one of the few parasites that can infect red blood cells as it multiplies inside an internal compartment called parasitophorous vacuole. Eventually, both the vacuole and red blood cells break allow the release of a new generation of parasites.
Researchers have demonstrated in a clinical trial that a new vaccine for malaria has been up to 100 percent effective when assessed at 10 weeks after last dose of vaccine.
Researchers have identified gene expression signatures in the blood of RTS,S-vaccinated volunteers, which predict the likelihood of infection after exposure to parasite-carrying mosquitoes.
Rapid diagnostic tests (RDTs) account for more than 70 percent of diagnostic testing for malaria in Africa. Most rapid test diagnostics rely on the detection an antigen specific to Plasmodium falciparum malaria. However, one of every 15 children infected with Plasmodium falciparum malaria parasites is infected by a mutant, producing a false-negative result when an RDT is used, investigators report.