Tổng hợp các nghiên cứu về kháng thuốc sốt rét dưới góc độ phân tử
Trong thời gian qua, với xu hướng giảm thấp của bệnh nhân sốt rét, ký sinh trùng sốt rét tại hâù hết các vùng sốt rét lưu hành trên thế giới, đặc biệt tại khu vực Đông Nam châu Á và Tiểu vùng Sông Mekong (GMS), dù vậy chúng ta vẫn đang đối mặt nhiều thách thức khó khăn trong kiểm soát và loại trừ sốt rét do đang phải đối mặt nhiều vấn đề phức tạp gồm sốt rét trên dân di biến động, ký sinh trùng kháng thuốc, muỗi sốt rét tăng sức chịu đựng và kháng với hóa chất hiện dùng và dẫn giao lưu biên giới, đi rừng ngủ rẫy tại các vùng có sốt rét lưu hành nặng.
Với các biện pháp kiểm soát như hiện nay đã góp phần không nhỏ vào khống chế sót rét, bên cạnh đó vai trò của các công cụ sinh học phân tử cũng đóng vai trò then chốt và có giá trị nhất định để đánh giá tình trạng người mang ký sinh trùng không triệu chứng và ký sinh trùng hay muỗi kháng hóa chất. Dưới đây là một số nghiên cứu được thực hiện trong thời gian qua về vai trò sinh học phân tử trong lĩnh vực sốt rét.
Optimal health and disease management using spatial uncertainty: a geographic characterization of emergent artemisinin-resistant Plasmodium falciparum distributions in Southeast Asia.
Grist EP, Flegg JA, Humphreys G, Mas IS, Anderson TJ, Ashley EA, Day NP, Dhorda M, Dondorp AM, Faiz MA, Gething PW, Hien TT, Hlaing TM, Imwong M, Kindermans JM, Maude RJ, Mayxay M, McDew-White M, Menard D, Nair S, Nosten F, Newton PN, Price RN, Pukrittayakamee S, Takala-Harrison S, Smithuis F, Nguyen NT, Tun KM, White NJ, Witkowski B, Woodrow CJ, Fairhurst RM, Sibley CH, Guerin PJ.
Int J Health Geogr . 2016 Oct 24;15(1):37.
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Lack of artemisinin resistance in Plasmodium falciparum in northwest Benin after 10 years of use of artemisinin-based combination therapy.
Ogouyèmi-Hounto A, Damien G, Deme AB, Ndam NT, Assohou C, Tchonlin D, Mama A, Hounkpe VO, Moutouama JD, Remoué F, Ndiaye D, Gazard DK.
Parasite . 2016;23:28. doi: 10.1051/parasite/2016028. Epub 2016 Jul 21.
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Polymorphisms of the artemisinin resistant marker (K13) in Plasmodium falciparum parasite populations of Grande Comore Island 10 years after artemisinin combination therapy.
Huang B, Deng C, Yang T, Xue L, Wang Q, Huang S, Su XZ, Liu Y, Zheng S, Guan Y, Xu Q, Zhou J, Yuan J, Bacar A, Abdallah KS, Attoumane R, Mliva AM, Zhong Y, Lu F, Song J.
Parasit Vectors . 2015 Dec 15;8:634. doi: 10.1186/s13071-015-1253-z.
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The challenge of artemisinin resistance can only be met by eliminating Plasmodium falciparum malaria across the Greater Mekong subregion.
Smith Gueye C, Newby G, Hwang J, Phillips AA, Whittaker M, MacArthur JR, Gosling RD, Feachem RG.
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Artemisinin resistance-associated polymorphisms at the K13-propeller locus are absent in Plasmodium falciparum isolates from Haiti.
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Am J Trop Med Hyg . 2015 Mar;92(3):552-4. doi: 10.4269/ajtmh.14-0664. Epub 2015 Feb 2.
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White NJ.
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Novel mutations in K13 propeller gene of artemisinin-resistant Plasmodium falciparum.
Isozumi R, Uemura H, Kimata I, Ichinose Y, Logedi J, Omar AH, Kaneko A.
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[Artemisinin resistance in Plasmodium falciparum: global status and basic research].
Zhao SM, Wang MY.
Zhongguo Ji Sheng Chong Xue Yu Ji Sheng Chong Bing Za Zhi . 2014 Oct;32(5):380-4. Review. Chinese.
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Ménard D, Khim N, Beghain J, Adegnika AA, Shafiul-Alam M, Amodu O, Rahim-Awab G, Barnadas C, Berry A, Boum Y, Bustos MD, Cao J, Chen JH, Collet L, Cui L, Thakur GD, Dieye A, Djallé D, Dorkenoo MA, Eboumbou-Moukoko CE, Espino FE, Fandeur T, Ferreira-da-Cruz MF, Fola AA, Fuehrer HP, Hassan AM, Herrera S, Hongvanthong B, Houzé S, Ibrahim ML, Jahirul-Karim M, Jiang L, Kano S, Ali-Khan W, Khanthavong M, Kremsner PG, Lacerda M, Leang R, Leelawong M, Li M, Lin K, Mazarati JB, Ménard S, Morlais I, Muhindo-Mavoko H, Musset L, Na-Bangchang K, Nambozi M, Niaré K, Noedl H, Ouédraogo JB, Pillai DR, Pradines B, Quang-Phuc B, Ramharter M, Randrianarivelojosia M, Sattabongkot J, Sheikh-Omar A, Silué KD, Sirima SB, Sutherland C, Syafruddin D, Tahar R, Tang LH, Touré OA, Tshibangu-wa-Tshibangu P, Vigan-Womas I, Warsame M, Wini L, Zakeri S, Kim S, Eam R, Berne L, Khean C, Chy S, Ken M, Loch K, Canier L, Duru V, Legrand E, Barale JC, Stokes B, Straimer J, Witkowski B, Fidock DA, Rogier C, Ringwald P, Ariey F, Mercereau-Puijalon O; KARMA Consortium.
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Menard S, Tchoufack JN, Maffo CN, Nsango SE, Iriart X, Abate L, Tsapi MT, Awono-Ambéné PH, Abega Mekongo FA, Morlais I, Berry A.
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Talundzic E, Okoth SA, Congpuong K, Plucinski MM, Morton L, Goldman IF, Kachur PS, Wongsrichanalai C, Satimai W, Barnwell JW, Udhayakumar V.
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Mekong malaria. Malaria, multi-drug resistance and economic development in the greater Mekong subregion of Southeast Asia.
Singhasivanon P.
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Genomic epidemiology of artemisinin resistant malaria.
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Lack of K13 mutations in Plasmodium falciparum persisting after artemisinin combination therapy treatment of Kenyan children.
Muwanguzi J, Henriques G, Sawa P, Bousema T, Sutherland CJ, Beshir KB.
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Artemisinin derivatives and malaria: useful, in combination with other antimalarials.
[No authors listed]
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Monitoring for Plasmodium falciparum drug resistance to artemisinin and artesunate in Binh Phuoc Province, Vietnam: 1998-2009.
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