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Phần 2. Cập nhật thông tin và tổng hợp y văn về tình hình bệnh nhiễm trùng do virus Ebola

            Tiếp theo Phần 1: Cập nhật thông tin và tổng hợp y văn về tình hình bệnh nhiễm trùng do virus Ebola

           Nhiễm virus Ebola là một trong những nhiễm trùng nguy hiểm nhất, gây biến chứng và tử vong cao. Ngày 31/5, Bộ Y tế tổ chức họp đánh giá tình hình dịch bệnh Ebola để xác định nguy cơ dịch xâm nhập vào nước ra cũng như đề xuất phương án phòng chống dịch tại Việt Nam.

Theo thông tin từ Cơ quan đầu mối quốc gia thực hiện Điều lệ Y tế quốc tế và đại diện Tổ chức Y tế thế giới TCYTTG), dịch bệnh Ebola tái bùng phát tại Congo từ đầu tháng 4/2018, đến ngày 29/5 đã ghi nhận 58 trường hợp nghi ngờ mắc bệnh Ebola, trong đó có 27 trường hợp tử vong (tỷ lệ chết/mắc 47%). Có 35 trường hợp xác định, 23 trường hợp nghi ngờ, trong đó có 3 trường hợp là nhân viên y tế.

Các trường hợp mắc tập trung tại 3 huyện: Bikoro, Iboko và Wangata. Đây là khu vực hẻo lánh cách xa thủ đô Kinshasa, có ít khách du lịch và có điều kiện đi lại khó khăn, phương tiện đi lại từ thủ đô Kinshasa đến khu vực này chủ yếu là bằng máy bay trực thăng. Hiện tại, các quốc gia lân cận và các quốc gia khác chưa ghi nhận trường hợp bệnh Ebola.

Căn cứ tình hình dịch bệnh Ebola tại Congo, thời gian tới khả năng xâm nhập dịch bệnh Ebola từ Congo vào nước ta là thấp. Do dịch bệnh Ebola chủ yếu xảy ra tại khu vực hẻo lánh của Congo, sự giao lưu thương mại giữa Việt Nam và Congo hiện rất ít song không loại trừ có thể ghi nhận trường hợp bệnh Ebola về từ vùng có dịch vào nước nước ta. Để chủ động ngăn ngừa dịch bệnh Ebola xâm nhập vào nước ta, cuộc họp đã thống nhất cần tiếp tục đẩy mạnh triển khai giám sát tại cửa khẩu và tại các bệnh viện nhằm phát hiện sớm trường hợp nghi ngờ mắc bệnh Ebola.






Hình 1-2-3

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The pathogenesis of Ebola hemorrhagic fever.

Takada A, Kawaoka Y.

Trends Microbiol. 2001 Oct;9(10):506-11. Review.

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Ebola virus: from discovery to vaccine.

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Nat Rev Immunol. 2003 Aug;3(8):677-85. Review.

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[Hope for a vaccine against ebola virus].

Holzgrabe U.

Pharm Unserer Zeit. 2001;30(3):185-6. German. No abstract available.

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Towards a vaccine against Ebola virus.

Geisbert TW, Jahrling PB.

Expert Rev Vaccines. 2003 Dec;2(6):777-89. Review.

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A single shot against Ebola and Marburg virus.

Baize S.

Nat Med. 2005 Jul;11(7):720-1. No abstract available.

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Ebola virus: unravelling pathogenesis to combat a deadly disease.

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Trends Mol Med. 2006 May;12(5):206-15. Epub 2006 Apr 17. Review.

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Ebola virus: the search for vaccines and treatments.

Wilson JA, Bosio CM, Hart MK.

Cell Mol Life Sci. 2001 Nov;58(12-13):1826-41. Review.

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Clarke T, Knight J.

Nature. 2003 Aug 7;424(6949):602. No abstract available.

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Folks T.

Nat Med. 1998 Jan;4(1):16-7. No abstract available.

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Progress towards the treatment of Ebola haemorrhagic fever.

Ströher U, Feldmann H.

Expert Opin Investig Drugs. 2006 Dec;15(12):1523-35. Review.

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Filovirus infection of STAT-1 knockout mice.

Raymond J, Bradfute S, Bray M.

J Infect Dis. 2011 Nov;204 Suppl 3:S986-90. doi: 10.1093/infdis/jir335.

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Immunopathology of highly virulent pathogens: insights from Ebola virus.

Zampieri CA, Sullivan NJ, Nabel GJ.

Nat Immunol. 2007 Nov;8(11):1159-64. Review.

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Evidence against an important role for infectivity-enhancing antibodies in Ebola virus infections.

Geisbert TW, Hensley LE, Geisbert JB, Jahrling PB.

Virology. 2002 Feb 1;293(1):15-9.

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Ebola virus: new insights into disease aetiopathology and possible therapeutic interventions.

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Expert Rev Mol Med. 2004 Sep 21;6(20):1-24. Review.

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Accelerated vaccination for Ebola virus haemorrhagic fever in non-human primates.

Sullivan NJ, Geisbert TW, Geisbert JB, Xu L, Yang ZY, Roederer M, Koup RA, Jahrling PB, Nabel GJ.

Nature. 2003 Aug 7;424(6949):681-4.

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Battling Ebola: the virus and the fear.

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IAVI Rep. 2014;18(4):11-3. No abstract available.

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Evaluation in nonhuman primates of vaccines against Ebola virus.

Geisbert TW, Pushko P, Anderson K, Smith J, Davis KJ, Jahrling PB.

Emerg Infect Dis. 2002 May;8(5):503-7.

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Ebola vaccine gets corporate backer.

Dove A.

Nat Med. 2002 Jul;8(7):645-6. No abstract available.

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Do therapeutic antibodies hold the key to an effective treatment for Ebola hemorrhagic fever?

Takada A.

Immunotherapy. 2013 May;5(5):441-3. doi: 10.2217/imt.13.29. No abstract available.

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Protection from Ebola virus mediated by cytotoxic T lymphocytes specific for the viral nucleoprotein.

Wilson JA, Hart MK.

J Virol. 2001 Mar;75(6):2660-4.

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Emerging diseases. o­n the trail of Ebola and Marburg viruses.

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Science. 2000 Nov 3;290(5493):923-5. No abstract available.

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Vaccine research efforts for filoviruses.

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Int J Parasitol. 2003 May;33(5-6):583-95. Review.

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Ebola: small, but real progress.

Birmingham K, Cooney S.

Nat Med. 2002 Apr;8(4):313. No abstract available.

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Large-scale convalescent blood and plasma transfusion therapy for Ebola virus disease.

Colebunders RL, Cannon RO.

J Infect Dis. 2015 Apr 15;211(8):1208-10. doi: 10.1093/infdis/jiv043. Epub 2015 Jan 29. No abstract available.

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Immunization for Ebola virus infection.

Xu L, Sanchez A, Yang Z, Zaki SR, Nabel EG, Nichol ST, Nabel GJ.

Nat Med. 1998 Jan;4(1):37-42.

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Virology. New vaccine and treatment excite Ebola researchers.

Enserink M.

Science. 2003 Nov 14;302(5648):1141-2. No abstract available.

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Ebola and Marburg hemorrhagic fever viruses: update o­n filoviruses.

Leroy E, Baize S, Gonzalez JP.

Med Trop (Mars). 2011 Apr;71(2):111-21. Review. French.

PMID: 21695865 Similar articlesSelect item 1794097730.






Hình 4-5-6

Assessment of a vesicular stomatitis virus-based vaccine by use of the mouse model of Ebola virus hemorrhagic fever.

Jones SM, Stroher U, Fernando L, Qiu X, Alimonti J, Melito P, Bray M, Klenk HD, Feldmann H.

J Infect Dis. 2007 Nov 15;196 Suppl 2:S404-12.

PMID: 17940977 Similar articlesSelect item 1121767431.

Experimental vaccine protects monkeys against Ebola virus.

Gottlieb S.

Bull World Health Organ. 2001;79(1):79. Epub 2003 Nov 5. No abstract available.

PMID: 11217674 Free PMC Article Similar articlesSelect item 1869276532.

Ebola images emerge from the cave.

Diamond MS, Fremont DH.

Cell Host Microbe. 2008 Aug 14;4(2):87-9. doi: 10.1016/j.chom.2008.07.011.

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Comparison of individual and combination DNA vaccines for B. anthracis, Ebola virus, Marburg virus and Venezuelan equine encephalitis virus.

Riemenschneider J, Garrison A, Geisbert J, Jahrling P, Hevey M, Negley D, Schmaljohn A, Lee J, Hart MK, Vanderzanden L, Custer D, Bray M, Ruff A, Ivins B, Bassett A, Rossi C, Schmaljohn C.

Vaccine. 2003 Sep 8;21(25-26):4071-80.

PMID: 12922144 Similar articlesSelect item 1218690134.


Hình 7

Induction of immune responses in mice and monkeys to Ebola virus after immunization with liposome-encapsulated irradiated Ebola virus: protection in mice requires CD4(+) T cells.

Rao M, Bray M, Alving CR, Jahrling P, Matyas GR.

J Virol. 2002 Sep;76(18):9176-85.

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Epitopes involved in antibody-mediated protection from Ebola virus.

Wilson JA, Hevey M, Bakken R, Guest S, Bray M, Schmaljohn AL, Hart MK.

Science. 2000 Mar 3;287(5458):1664-6.

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International Colloquium o­n Ebola Virus Research: summary report.

Breman JG, van der Groen G, Peters CJ, Heymann DL.

J Infect Dis. 1997 Oct;176(4):1058-63. No abstract available.

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[An effective vaccine against Ebola hemorrhagic fever].

Pospísil L.

Vnitr Lek. 2004 Jan;50(1):76. Czech. No abstract available.

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Hình 8

Antibody-dependent enhancement of Ebola virus infection.

Takada A, Feldmann H, Ksiazek TG, Kawaoka Y.

J Virol. 2003 Jul;77(13):7539-44.

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Ebola and Marburg viruses: pathogenesis and development of countermeasures.

Hensley LE, Jones SM, Feldmann H, Jahrling PB, Geisbert TW.

Curr Mol Med. 2005 Dec;5(8):761-72. Review.

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[Properties of the Ebola virus glycoprotein].

Takada A.

Uirusu. 2006 Jun;56(1):117-24. Review. Japanese.

PMID: 17038820 Free Article Similar articles

Ebola virus-like particles protect from lethal Ebola virus infection.

Warfield KL, Bosio CM, Welcher BC, Deal EM, Mohamadzadeh M, Schmaljohn A, Aman MJ, Bavari S.

Proc Natl Acad Sci U S A. 2003 Dec 23;100(26):15889-94. Epub 2003 Dec 12.

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Ebola virus: the role of macrophages and dendritic cells in the pathogenesis of Ebola hemorrhagic fever.

Bray M, Geisbert TW.

Int J Biochem Cell Biol. 2005 Aug;37(8):1560-6. Epub 2005 Mar 7.

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Persistent infection with ebola virus under conditions of partial immunity.

Gupta M, Mahanty S, Greer P, Towner JS, Shieh WJ, Zaki SR, Ahmed R, Rollin PE.

J Virol. 2004 Jan;78(2):958-67.

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Hình 9

Development of a cAdVax-based bivalent ebola virus vaccine that induces immune responses against both the Sudan and Zaire species of Ebola virus.

Wang D, Raja NU, Trubey CM, Juompan LY, Luo M, Woraratanadharm J, Deitz SB, Yu H, Swain BM, Moore KM, Pratt WD, Hart MK, Dong JY.

J Virol. 2006 Mar;80(6):2738-46.

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Rethinking the Response to Emerging Microbes: Vaccines and Therapeutics in the Ebola Era--a Conference at Harvard Medical School.

Knipe DM, Whelan SP.

J Virol. 2015 Aug;89(15):7446-8. doi: 10.1128/JVI.01251-15. Epub 2015 May 20.

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[Viral hemorrhagic fevers--Ebola hemorrhagic fever, Marburg virus disease, and Lassa fever].

Taniguchi K.

Nihon Naika Gakkai Zasshi. 2004 Nov 10;93(11):2303-8. Review. Japanese. No abstract available.

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[Ebola: "a fatal syndrome"].

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Bol Asoc Med P R. 1996 Jul-Sep;88(7-9):69-72. Review. Spanish.

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Progress in recombinant DNA-derived vaccines for Lassa virus and filoviruses.

Grant-Klein RJ, Altamura LA, Schmaljohn CS.

Virus Res. 2011 Dec;162(1-2):148-61. doi: 10.1016/j.virusres.2011.09.005. Epub 2011 Sep 10. Review.

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Hình 10

[Ebola virus and Marburg virus].

Morikawa S.

Nihon Rinsho. 2003 Mar;61 Suppl 3:544-9. Review. Japanese. No abstract available.

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[Therapeutic use of immune sera. Ebola survivors as lifesavers?].

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MMW Fortschr Med. 2014 Nov 6;156(19):6. German. No abstract available.

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Preparation and use of hyperimmune serum for prophylaxis and therapy of Ebola virus infections.

Kudoyarova-Zubavichene NM, Sergeyev NN, Chepurnov AA, Netesov SV.

J Infect Dis. 1999 Feb;179 Suppl 1:S218-23.

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Treatment of Ebola virus infection with antibodies from reconvalescent donors.

Kreil TR.

Emerg Infect Dis. 2015 Mar;21(3):521-3. doi: 10.3201/eid2103.141838.

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Recent advances in Ebolavirus vaccine development.

Richardson JS, Dekker JD, Croyle MA, Kobinger GP.

Hum Vaccin. 2010 Jun;6(6):439-49. Epub 2010 Jun 1. Review.

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An uncertain defense. How do you test that a human Ebola vaccine works? You don't.

Gibbs WW.

Sci Am. 2004 Oct;291(4):20, 24. No abstract available.

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Hartman AL, Towner JS, Nichol ST.

Clin Lab Med. 2010 Mar;30(1):161-77. doi: 10.1016/j.cll.2009.12.001. Review.

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Development of a preventive vaccine for Ebola virus infection in primates.

Sullivan NJ, Sanchez A, Rollin PE, Yang ZY, Nabel GJ.

Nature. 2000 Nov 30;408(6812):605-9.

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Conference report - I. Investigating new vaccines: Ebola and HIV: highlights from the Viral Vaccine Meeting; October 25-28, 2003; Barcelona, Spain.

Armandola E.

MedGenMed. 2003 Dec 3;5(4):24. No abstract available.

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Chepurnov AA, Dadaeva AA, Kolesnikov SI.

Bull Exp Biol Med. 2001 Dec;132(6):1182-6.

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Takada A, Kawaoka Y.

Trends Microbiol. 1998 Jul;6(7):258-9. Review. No abstract available.

PMID: 9717212 Similar articles

Recombinant human monoclonal antibodies to Ebola virus.

Maruyama T, Parren PW, Sanchez A, Rensink I, Rodriguez LL, Khan AS, Peters CJ, Burton DR.

J Infect Dis. 1999 Feb;179 Suppl 1:S235-9.

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Comparison of the protective efficacy of DNA and baculovirus-derived protein vaccines for EBOLA virus in guinea pigs.

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Virus Res. 2003 Apr;92(2):187-93.

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The role of DC-SIGN and DC-SIGNR in HIV and Ebola virus infection: can potential therapeutics block virus transmission and dissemination?

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Wilson JA, Bray M, Bakken R, Hart MK.

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Vopr Virusol. 1999 Sep-Oct;44(5):217-20. Russian.

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Med Sci (Paris). 2006 Apr;22(4):405-10. Review. French.

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Pathology of experimental Ebola virus infection in African green monkeys. Involvement of fibroblastic reticular cells.

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Two strings to the bow of Ebola virus.

Klenk HD, Volchkov VE, Feldmann H.

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Protective efficacy of neutralizing antibodies against Ebola virus infection.

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Vaccine. 2007 Jan 22;25(6):993-9. Epub 2006 Oct 10.

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Catheterized guinea pigs infected with Ebola Zaire virus allows safer sequential sampling to determine the pharmacokinetic profile of a phosphatidylserine-targeting monoclonal antibody.

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Therapeutics of Ebola hemorrhagic fever: whole-genome transcriptional analysis of successful disease mitigation.

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Ebola, dogs and a vaccine.

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Aust Vet J. 2014 Dec;92(12):N8. No abstract available.

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[EBOLA HEMORRHAGIC FEVER: DIAGNOSTICS, ETIOTROPIC AND PATHOGENETIC THERAPY, PREVENTION].

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Klin Med (Mosk). 2015;93(9):5-11. Review. Russian.

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Hình 10-11-12

British nurse makes "full recovery" from reactivated Ebola virus.

Murphy H.

BMJ. 2015 Nov 12;351:h6133. doi: 10.1136/bmj.h6133. No abstract available.

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Ebola vaccines tested in humans, monkeys.

Vastag B.

JAMA. 2004 Feb 4;291(5):549-50. No abstract available.

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Ethical dilemma for Ebola drug trials.

Hayden EC.

Nature. 2014 Nov 13;515(7526):177-8. doi: 10.1038/515177a. No abstract available.

PMID: 25391940 Similar articles

Infectious diseases. Ebola drugs still stuck in lab.

Enserink M.

Science. 2014 Jul 25;345(6195):364-5. doi: 10.1126/science.345.6195.364. No abstract available.

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Out of Africa--caring for patients with Ebola.

Rubin EJ, Baden LR.

N Engl J Med. 2014 Dec 18;371(25):2430-2. doi: 10.1056/NEJMe1412744. Epub 2014 Nov 12. No abstract available.

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Robust and sustained immune activation in human Ebola virus infection.

Mandl JN, Feinberg MB.

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Ebola virus disease in mice with transplanted human hematopoietic stem cells.

Lüdtke A, Oestereich L, Ruibal P, Wurr S, Pallasch E, Bockholt S, Ip WH, Rieger T, Gómez-Medina S, Stocking C, Rodríguez E, Günther S, Muñoz-Fontela C.

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A dose of reality.

Cohen J, Kupferschmidt K.

Science. 2014 Nov 21;346(6212):908-11. doi: 10.1126/science.346.6212.908. No abstract available.

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Ebolavirus: a brief review of novel therapeutic targets.

Kondratowicz AS, Maury WJ.

Future Microbiol. 2012 Jan;7(1):1-4. doi: 10.2217/fmb.11.110. Review. No abstract available.

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Cox E, Borio L, Temple R.

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[Hematological and immunological parameters during Ebola virus passages in guinea-pigs].

Dadaeva AA, Sizikova LP, Subbotina EL, Chepurnov AA.

Vopr Virusol. 2006 Jul-Aug;51(4):32-7. Russian.

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N Engl J Med. 2015 Apr 23;372(17):1674. doi: 10.1056/NEJMc1500452. No abstract available.

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N Engl J Med. 2015 Apr 23;372(17):1673-4. doi: 10.1056/NEJMc1500452. No abstract available.

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[Functional activity of peritoneal macrophages in experimental Ebola fever].

Dadaeva AA, Sizikova LP, Chepurnov AA.

Vestn Ross Akad Med Nauk. 2004;(8):7-11. Russian.

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Younan P, Iampietro M, Bukreyev A.

PLoS Pathog. 2018 Apr 12;14(4):e1006932. doi: 10.1371/journal.ppat.1006932. eCollection 2018 Apr. No abstract available.

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Inactivated vaccine for Ebola virus efficacious in guineapig model.

Lupton HW, Lambert RD, Bumgardner DL, Moe JB, Eddy GA.

Lancet. 1980 Dec 13;2(8207):1294-5. No abstract available.

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Falzarano D, Feldmann H.

Science. 2015 Feb 27;347(6225):947-8. doi: 10.1126/science.aaa8121. No abstract available.

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Humanized Mice--A Neoteric Animal Disease Model for Ebola Virus?

Prescott J, Feldmann H.

J Infect Dis. 2016 Mar 1;213(5):691-3. doi: 10.1093/infdis/jiv539. Epub 2015 Nov 17. No abstract available.

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[A question of competence].

Rausch R.

Med Monatsschr Pharm. 2014 Sep;37(9):313. German. No abstract available.

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False alarms give hospital staff practice in managing Ebola care.

Osborne K.

Nurs Stand. 2014 Nov 11;29(10):10. doi: 10.7748/ns.29.10.10.s9.

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[In process].

Tetsch L.

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"China 1 USA 0": A Former Ebola Provider's Explanation Why the United States is Falling Behind in the Global Health Arena.

Owens MD.

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Mice strains offer genetic clues.

[No authors listed]

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Infectious diseases. Ebola survivors fight back in plasma studies.

Enserink M.

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Considerations regarding safe transport and transfer for Ebola patients in western countries.

Fusco FM, Puro V, Ippolito G.

Intensive Care Med. 2015 Jun;41(6):1175-6. doi: 10.1007/s00134-015-3825-y. Epub 2015 Apr 29. No abstract available.

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Coignard-Biehler H, Isakov A, Stephenson J.

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Nau JY.

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Chepurnov AA, Dadaeva AA, Sizikova LP, Pisanko VA.

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Halpern SD, Emanuel EJ.

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Clinical trials of Ebola therapies to begin in December.

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BMJ. 2014 Nov 14;349:g6827. doi: 10.1136/bmj.g6827. No abstract available.

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65th AALAS National Meeting.

[No authors listed]

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Bricaire F.

Bull Acad Natl Med. 2014 Nov;198(8):1501-4. French. No abstract available.

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Can transfusions aid Ebola fight?

Johnson SR.

Mod Healthc. 2014 Nov 3;44(44):18. No abstract available.

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Ngày 04/09/2018
TS.BS. Huỳnh Hồng Quang  

THÔNG BÁO

   Dịch vụ khám chữa bệnh chuyên khoa của Viện Sốt rét-KST-CT Quy Nhơn khám bệnh tất cả các ngày trong tuần (kể cả thứ 7 và chủ nhật)

   THÔNG BÁO: Phòng khám chuyên khoa Viện Sốt rét-KST-CT Quy Nhơn xin trân trọng thông báo thời gian mở cửa hoạt động trở lại vào ngày 20/10/2021.


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